Study on pathological and clinical characteristics of chronic HBV infected patients with HBsAg positive, HBV DNA negative, HBeAg negative

AimsStudy of clinical characteristics of hepatitis B virus deoxyribonucleic acid (HBV DNA)-negative, hepatitis B surface antigen (HBsAg)-positive, hepatitis B e antigen (HBeAg)-negative patients based on liver histopathology.MethodsWe retrospectively enrolled patients with chronic HBV infection diagnosis at Beijing Ditan Hospital from May 2008 to November 2020. To study the differences between patients with significant hepatic histopathology and those without significant hepatic histopathology. And to study the independent factors of significant hepatic histopathology.Results85 HBV DNA-negative and HBeAg-negative patients were 37.90 ± 10.30 years old, 23.50% of patients with grade of inflammation (G) >1, 35.30% of patients with liver fibrosis stage (S) >1, 44.70% patients were diagnosed with significant hepatic histopathology. Compared to the no significant hepatic histopathology group, another group had older age (41.70 ± 10.70 vs 34.80 ± 8.87 years, t=-3.28, P=0.002), higher total bilirubin (TBIL) [14.9(10.3, 22.4) vs 11(8.9, 14.4) μmol/L, z=-2.26, P=0.024], lower cholinesterase (CHE) (t=-2.86, P=0.005, 7388.00 ± 2156.00 vs 8988.00 ± 2823.00 U/L) and lower platelet (PLT) (t=2.75, P=0.007, 157.00 ± 61.40 vs 194.00 ± 61.00 10^9/L). Abnormal ALT patients are more likely to have significant hepatic histopathology (z=5.44, P=0.020, 66.70% vs 337.50%). G had significant correlation with CHE (P=0.008, r=-0.23), alanine aminotransferase (ALT) (P=0.041, r=0.18), aspartate aminotransferase (AST) (P=0.001, r=0.29). S had significant correlation with TBIL (P = 0.008, r = 0.23), age (P < 0.001, r = 0.32), international normalized ratio (INR) (P = 0.04, r = 0.23), CHE (P < 0.001, r = -0.30), PLT (P < 0.001, r = -0.40) and prothrombin time activity (PTA) (P = 0.046, r = -0.22). Multivariate logistic analysis indicated only age (95%CI=1.014~1.130, OR=1.069, P=0.013) was an impact factor for significant hepatic histopathology. The cutoff point of age was 34.30 years.ConclusionsA large proportion of chronic HBV infection patients with HBeAg-negative and HBV DNA-negative still have chronic hepatitis. Age is an independent factor for significant hepatic histopatholog

Differential Expression of Androgen Receptor

Abstract: This article demonstrates the expression in difference of androgen receptor with and without Guilong Kechuanning medication administration for heavy environmental tobacco smoke (ETS) treated rats. The discrepancy expression of androgen receptor reveals the efficiency of the Guilong Kechuanning medication administration in pneumotherapy

Numerical analysis for a crack in piezoelectric material under impact

AbstractIn this paper, a numerical analysis of impact interfacial fracture for a piezoelectric bimaterial is provided. Starting from the basic equilibrium equation, a dynamic electro-mechanical FEM formulation is briefly presented. Then, the path-independent separated dynamic J integral is extended to piezoelectric bimaterials. Based on the relationship of the path-independent dynamic J integral and the stress and electric displacement intensity factors, the component separation method is used to calculate the stress and electric displacement intensity factors for piezoelectric bimaterials in this finite-element analysis. The response curves of the dynamic J integral, the stress and electric displacement intensity factors are obtained for both homogeneous material (PZT-4 and CdSe) and CdSe/PZT-4 bimaterial. The influences of the piezoelectricity and the electro-mechanical coupling factor on these responses are discussed. The effects of an applied electric field are also discussed

Wettability of quartz particles at varying conditions on the basis of the measurement of relative wetting contact angles and their flotation behaviour

In this paper, on the basis of a modified Washburn equation, the squared incremental pressure due to liquid rising vs. time were measured instead of wicking distances before reaching equilibrium, and the relative wetting contact angles (RWCA) were applied to characterize the surface wettability of quartz particles conditioned at different concentrations of flotation reagents. Combined with the flotation experiments on quartz particles at corresponding conditions, the relationship between flotation recoveries and RWCA was analysed, which proves that RWCA can characterize the surface wettability of quartz particles accurately. The results also showed that the best reagent conditions for floating quartz are pH 12.0, a Ca2+ concentration of 1×10-3 mol/dm3 and a sodium oleate concentration of 0.75×10-3 mol/dm3, where the recovery of quartz is 86%. The surface tension of the filtrate of the pulp was determined by a fully-automatic tensiometer as well. Based on the measured values of RWCA and surface tension, the free energy changes (ΔG) before and after the adhesion of bubbles and particles per unit area at corresponding situations were calculated, respectively. The trends of ΔG varying with the concentrations of reagents were in close accordance with those of RWCA and the flotation recoveries, proving that it is more likely for particles having bigger contact angles to adhere to bubbles, resulting in a higher flotation recovery. These results give a more feasible and accurate approach to analysing the surface wettability and floatability of fine particles

The Characteristics and Contributing Factors of Air Pollution in Nanjing: A Case Study Based on an Unmanned Aerial Vehicle Experiment and Multiple Datasets

Unmanned aerial vehicle (UAV) experiments, multiple datasets from ground-based stations and satellite remote sensing platforms, and backward trajectory models were combined to investigate the characteristics and influential mechanisms of the air pollution episode that occurred in Nanjing during 3–4 December 2017. Before the experiments, the position of the detector mounted on a UAV that was minimally disturbed by the rotation of the rotors was analyzed based on computational fluid dynamics (CFD) simulations. The combined analysis indicated that the surface meteorological conditions—high relative humidity, low wind speed, and low temperature—were conducive to the accumulation of PM2.5. Strongly intense temperature inversion layers and the low thickness of the atmospheric mixed layer could have resulted in elevated PM2.5 mass concentrations. In the early stage, air pollution was affected by the synoptic circulation of the homogenous pressure field and low wind speeds, and the pollutants mainly originated from emissions from surrounding areas. The aggravated pollution was mainly attributed to the cold front and strong northwesterly winds above 850 hPa, and the pollutants mostly originated from the long-distance transport of emissions with northwesterly winds, mainly from the Beijing‒Tianjin‒Hebei (BTH) region and its surrounding areas. This long-distance transport predominated during this event. The air pollution level and aerosol optical depth (AOD) were positively correlated with respect to their spatial distributions; they could reflect shifts in areas of serious pollution. Pollution was concentrated in Anhui Province when it was alleviated in Nanjing. Polluted dust, polluted continental and smoke aerosols were primarily observed during this process. In particular, polluted dust aerosols accounted for a major part of the transport stage, and existed between the surface and 4 km. Moreover, the average extinction coefficient at lower altitudes (<1 km) was higher for aerosol deposition

Facile Fabrication of Dual Functional Graphene Oxide Microcapsules Carrying Corrosion Inhibitor and Encapsulating Self-Healing Agent

Dual functional graphene oxide (GO) microcapsules were fabricated through self-assembly in Pickering emulsions, carrying corrosion inhibitor benzotriazole (BTA) on the microcapsule shells and encapsulating a self-healing agent epoxy monomer. The formation of the GO microcapsules was assisted by the interaction between BTA and GO, which provided robust encapsulation for the epoxy monomer. The loading capacity of BTA and epoxy monomer reached 90.5%. The addition of the GO microcapsules simultaneously promoted the corrosion protection and self-healing properties of the waterborne epoxy composite coatings. The healing efficiency of the composite coatings reached over 99.7% when the content of the microcapsules was 10 wt%. Meanwhile, the corrosion current density of the intact coatings was decreased for around 50 times