INTERVIEW WITH PROFESSOR XIAO SHUIYUAN, CENTRAL SOUTH UNIVERSITY

肖水源博士多年来在中国研究社区精神卫生、精神卫生政策和自杀预防，是中国心理卫生协会危机干预专业委员会的主任委员、国际自杀预防研究院（IASR）委员，世界文化精神病学会委员，卫生部疾病控制专家委员会委员等。2000年获得国务院“特殊津贴专家”称号，2009年获得CMB“杰出教授”称号。Dr. XIAO Shuiyuan's research interests include community mental health, mental health policy, and suicide prevention. He is the Chair of the Committee on Crisis Intervention, the Chinese Association for Mental Health; member of the International Academy of Suicide Research, the World Association of Cultural Psychiatry, and the Expert Panel on Disease Prevention and Control for the Ministry of Health, China. He received the State Council " Special Allowance Expert” Award in 2000 and the “China Medical Board Distinguished Professorship” Award in 2009.

Lacidipine Attenuates Apoptosis via a Caspase-3 Dependent Pathway in Human Kidney Cells

Background: Acute kidney injury (AKI) is common in hospitalised patients and has a poor prognosis. Therefore, new therapeutic strategies are anticipated. Lacidipine, a novel third-generation dihydropyridine calcium channel blocker, has been demonstrated effective for hypertension. However, its potential effect on renal injury remains unknown. In the present study, an in vitro model of renal ischemia reperfusion (I/R) injury was used to investigate the protective effect and underlying mechanisms of lacidipine on human kidney cell (HKC) apoptosis. Methods: HKCs were subjected to adenosine triphosphate (ATP) depletion and recovery (0.01 µM AA, depletion for 2 h and recovery for 30 min), with or without lacidipine (1 µM and 10 µM, 24 h), then cell viability and apoptosis were determined using the cell counting kit-8 (CCK-8) assay and Annexin V flow cytometry. The expression of Bcl-2, Bax, and cytochrome c (cyt c) was examined by western blot. Results: Antimycin A (AA) was found to induce apoptosis of HKCs. The proportion of early apoptosis and activity of caspase-3 peaked at 30 min after ATP depletion and recovery and were attenuated by lacidipine. The expression of cyt c and Bax was decreased, while that of Bcl-2 was increased significantly in lacidipine treated group. Conclusion: We conclude that lacidipine protects HKCs against apoptosis induced by ATP depletion and recovery by regulating the caspase-3 pathway

Zeolitic Imidazolate Framework 67-Derived Ce-Doped CoP@N-Doped Carbon Hollow Polyhedron as High-Performance Anodes for Lithium-Ion Batteries

Zeolitic Imidazolate Framework 67 (ZIF-67) and its derivates have attracted extensive interest for lithium-ion batteries (LIBs). Here, Cerium-doped cobalt phosphide@nitrogen-doped carbon (Ce-doped CoP@NC) with hollow polyhedron structure materials were successfully synthesized via ionic-exchange with Co and Ce ions using the ZIF-67 as a template followed with a facile low-temperature phosphorization treatment. Benefitting from the well-designed hollow polyhedron, steady carbon network, and Ce-doping structural merits, the as-synthesized Ce-doped CoP@NC electrode demonstrated superior performance as the anode in LIBs: a superior cyclability (400 mA h g−1 after 500 cycles) and outstanding rate-capability (590 mA h g−1, reverted to 100 mA g−1 ). These features not only produced more lithium-active sites for LIBs anode and a shorter Li-ion diffusion pathway to expedite the charge transfer, but also the better tolerance against volume variation of CoP during the repeated lithiation/delithiation process and greater electronic conductivity prop-erties. These results provide a methodology for the design of well-organized ZIFs and rare earth element-doped transition metal phosphate with a hollow polyhedron structure