Global burden, trends, and inequalities of ischemic heart disease among young adults from 1990 to 2019: a population-based study

BackgroundIschemic heart disease (IHD) is a major global health concern, and its burden among young adults aged 25–49 years remains underexplored. This study aims to provide a comprehensive assessment of the global burden and trends of IHD over the past 30 years (1990–2019) among this age group, as well as to analyze the health inequalities related to socioeconomic development.MethodsData from Global Burden of Disease Study 2019 (GBD 2019) were utilized to analyze the prevalence, mortality, and disability-adjusted life years (DALYs) rate of IHD among young adults globally. Joinpoint regression analysis was applied to examine the trends over the study period. Health inequality analysis was performed to investigate the disparities in IHD burden related to the Socio-Demographic Index (SDI) of countries.ResultsAccording to GBD 2019 data, in 2019, the global numbers of young adults with IHD cases, deaths, and DALYs were 18,050,671 (95% UI, 15,551,940–21,254,746), 597,137 (548,250–647,778), and 28,692,968 (26,397,448–31,178,464), respectively, accounting for 9.15%, 6.53%, and 15.7% of the total global cases. Over the past 30 years, the mortality [AAPC = −0.4%, 95% CI (−0.7% to −0.1%)] and DALYs rate [AAPC = −0.3%, 95% CI (−0.6% to −0.1%)] of IHD among young adults decreased, while the prevalence rate [AAPC = 0.4%, 95% CI (0.4%–0.4%)] and YLDs rate [AAPC = 0.4%, 95% CI (0.3%–0.4%)] increased. Furthermore, countries with lower levels of socio-demographic index (SDI) disproportionately bore a higher burden of IHD among young adults. The inequality slope index for young adult IHD shifted from −56.6 [95% CI (−480.4–370.2)] in 1990 to −583.0 [95% CI (−996.8 to −169.2)] in 2019, and the concentration index moved from −8.2 [95% CI (−8.5 to −7.9)] in 1990 to −13.2 [95% CI (−13.9 to −12.4)] in 2019.ConclusionsWhile the mortality and DALYs rate of IHD among global young adults have decreased over the past 30 years, the degree of inequality related to SDI among countries has continued to increase. Decision-makers in various countries should allocate resources wisely and implement effective strategies to improve the burden of young adults IHD globally and address the health inequalities associated with it

Genetic Diversity of Daphnia pulex in the Middle and Lower Reaches of the Yangtze River.

Increased human activities and environmental changes may lead to genetic diversity variations of Cladocerans in water. Daphnia pulex are distributed throughout the world and often regarded as a model organism. The 16S rDNA, cytochrome c oxidase subunit I (COI), and 18S genes were used as molecular marks. The genetic diversity and phylogeny of D. pulex obtained from 10 water bodies in the middle and lower reaches of the Yangtze River were studied. For 16S rDNA, COI gene, and 18S gene, the A+T content (65.4%, 58.4%, and 54.6%) was significantly higher than the G+C content (34.6%, 41.6% and 45.4%). This result was consistent with higher A and T contents among invertebrates. Based on the genetic distances of 16S rDNA and COI genes, the genetic differences of D. pulex from 10 water bodies located in the middle and lower reaches of the Yangtze River in China was minimal (0%-0.8% for 16S rDNA and 0%-1.5% for COI gene). However, D. pulex evolved into two branches in the phylogenetic trees, which coincided with its geographical distribution. Compared with D. pulex from other countries, the average genetic distance of D. pulex obtained from 10 water bodies in the middle and lower reaches of the Yangtze River reached 9.1%-10.5%, thereby indicating that D. pulex may have evolved into different subspecies

Datasheet4_Global burden, trends, and inequalities of ischemic heart disease among young adults from 1990 to 2019: a population-based study.csv

BackgroundIschemic heart disease (IHD) is a major global health concern, and its burden among young adults aged 25–49 years remains underexplored. This study aims to provide a comprehensive assessment of the global burden and trends of IHD over the past 30 years (1990–2019) among this age group, as well as to analyze the health inequalities related to socioeconomic development.MethodsData from Global Burden of Disease Study 2019 (GBD 2019) were utilized to analyze the prevalence, mortality, and disability-adjusted life years (DALYs) rate of IHD among young adults globally. Joinpoint regression analysis was applied to examine the trends over the study period. Health inequality analysis was performed to investigate the disparities in IHD burden related to the Socio-Demographic Index (SDI) of countries.ResultsAccording to GBD 2019 data, in 2019, the global numbers of young adults with IHD cases, deaths, and DALYs were 18,050,671 (95% UI, 15,551,940–21,254,746), 597,137 (548,250–647,778), and 28,692,968 (26,397,448–31,178,464), respectively, accounting for 9.15%, 6.53%, and 15.7% of the total global cases. Over the past 30 years, the mortality [AAPC = −0.4%, 95% CI (−0.7% to −0.1%)] and DALYs rate [AAPC = −0.3%, 95% CI (−0.6% to −0.1%)] of IHD among young adults decreased, while the prevalence rate [AAPC = 0.4%, 95% CI (0.4%–0.4%)] and YLDs rate [AAPC = 0.4%, 95% CI (0.3%–0.4%)] increased. Furthermore, countries with lower levels of socio-demographic index (SDI) disproportionately bore a higher burden of IHD among young adults. The inequality slope index for young adult IHD shifted from −56.6 [95% CI (−480.4–370.2)] in 1990 to −583.0 [95% CI (−996.8 to −169.2)] in 2019, and the concentration index moved from −8.2 [95% CI (−8.5 to −7.9)] in 1990 to −13.2 [95% CI (−13.9 to −12.4)] in 2019.ConclusionsWhile the mortality and DALYs rate of IHD among global young adults have decreased over the past 30 years, the degree of inequality related to SDI among countries has continued to increase. Decision-makers in various countries should allocate resources wisely and implement effective strategies to improve the burden of young adults IHD globally and address the health inequalities associated with it.</p

Datasheet1_Global burden, trends, and inequalities of ischemic heart disease among young adults from 1990 to 2019: a population-based study.csv

BackgroundIschemic heart disease (IHD) is a major global health concern, and its burden among young adults aged 25–49 years remains underexplored. This study aims to provide a comprehensive assessment of the global burden and trends of IHD over the past 30 years (1990–2019) among this age group, as well as to analyze the health inequalities related to socioeconomic development.MethodsData from Global Burden of Disease Study 2019 (GBD 2019) were utilized to analyze the prevalence, mortality, and disability-adjusted life years (DALYs) rate of IHD among young adults globally. Joinpoint regression analysis was applied to examine the trends over the study period. Health inequality analysis was performed to investigate the disparities in IHD burden related to the Socio-Demographic Index (SDI) of countries.ResultsAccording to GBD 2019 data, in 2019, the global numbers of young adults with IHD cases, deaths, and DALYs were 18,050,671 (95% UI, 15,551,940–21,254,746), 597,137 (548,250–647,778), and 28,692,968 (26,397,448–31,178,464), respectively, accounting for 9.15%, 6.53%, and 15.7% of the total global cases. Over the past 30 years, the mortality [AAPC = −0.4%, 95% CI (−0.7% to −0.1%)] and DALYs rate [AAPC = −0.3%, 95% CI (−0.6% to −0.1%)] of IHD among young adults decreased, while the prevalence rate [AAPC = 0.4%, 95% CI (0.4%–0.4%)] and YLDs rate [AAPC = 0.4%, 95% CI (0.3%–0.4%)] increased. Furthermore, countries with lower levels of socio-demographic index (SDI) disproportionately bore a higher burden of IHD among young adults. The inequality slope index for young adult IHD shifted from −56.6 [95% CI (−480.4–370.2)] in 1990 to −583.0 [95% CI (−996.8 to −169.2)] in 2019, and the concentration index moved from −8.2 [95% CI (−8.5 to −7.9)] in 1990 to −13.2 [95% CI (−13.9 to −12.4)] in 2019.ConclusionsWhile the mortality and DALYs rate of IHD among global young adults have decreased over the past 30 years, the degree of inequality related to SDI among countries has continued to increase. Decision-makers in various countries should allocate resources wisely and implement effective strategies to improve the burden of young adults IHD globally and address the health inequalities associated with it.</p

Datasheet6_Global burden, trends, and inequalities of ischemic heart disease among young adults from 1990 to 2019: a population-based study.csv

BackgroundIschemic heart disease (IHD) is a major global health concern, and its burden among young adults aged 25–49 years remains underexplored. This study aims to provide a comprehensive assessment of the global burden and trends of IHD over the past 30 years (1990–2019) among this age group, as well as to analyze the health inequalities related to socioeconomic development.MethodsData from Global Burden of Disease Study 2019 (GBD 2019) were utilized to analyze the prevalence, mortality, and disability-adjusted life years (DALYs) rate of IHD among young adults globally. Joinpoint regression analysis was applied to examine the trends over the study period. Health inequality analysis was performed to investigate the disparities in IHD burden related to the Socio-Demographic Index (SDI) of countries.ResultsAccording to GBD 2019 data, in 2019, the global numbers of young adults with IHD cases, deaths, and DALYs were 18,050,671 (95% UI, 15,551,940–21,254,746), 597,137 (548,250–647,778), and 28,692,968 (26,397,448–31,178,464), respectively, accounting for 9.15%, 6.53%, and 15.7% of the total global cases. Over the past 30 years, the mortality [AAPC = −0.4%, 95% CI (−0.7% to −0.1%)] and DALYs rate [AAPC = −0.3%, 95% CI (−0.6% to −0.1%)] of IHD among young adults decreased, while the prevalence rate [AAPC = 0.4%, 95% CI (0.4%–0.4%)] and YLDs rate [AAPC = 0.4%, 95% CI (0.3%–0.4%)] increased. Furthermore, countries with lower levels of socio-demographic index (SDI) disproportionately bore a higher burden of IHD among young adults. The inequality slope index for young adult IHD shifted from −56.6 [95% CI (−480.4–370.2)] in 1990 to −583.0 [95% CI (−996.8 to −169.2)] in 2019, and the concentration index moved from −8.2 [95% CI (−8.5 to −7.9)] in 1990 to −13.2 [95% CI (−13.9 to −12.4)] in 2019.ConclusionsWhile the mortality and DALYs rate of IHD among global young adults have decreased over the past 30 years, the degree of inequality related to SDI among countries has continued to increase. Decision-makers in various countries should allocate resources wisely and implement effective strategies to improve the burden of young adults IHD globally and address the health inequalities associated with it.</p

Datasheet5_Global burden, trends, and inequalities of ischemic heart disease among young adults from 1990 to 2019: a population-based study.csv

BackgroundIschemic heart disease (IHD) is a major global health concern, and its burden among young adults aged 25–49 years remains underexplored. This study aims to provide a comprehensive assessment of the global burden and trends of IHD over the past 30 years (1990–2019) among this age group, as well as to analyze the health inequalities related to socioeconomic development.MethodsData from Global Burden of Disease Study 2019 (GBD 2019) were utilized to analyze the prevalence, mortality, and disability-adjusted life years (DALYs) rate of IHD among young adults globally. Joinpoint regression analysis was applied to examine the trends over the study period. Health inequality analysis was performed to investigate the disparities in IHD burden related to the Socio-Demographic Index (SDI) of countries.ResultsAccording to GBD 2019 data, in 2019, the global numbers of young adults with IHD cases, deaths, and DALYs were 18,050,671 (95% UI, 15,551,940–21,254,746), 597,137 (548,250–647,778), and 28,692,968 (26,397,448–31,178,464), respectively, accounting for 9.15%, 6.53%, and 15.7% of the total global cases. Over the past 30 years, the mortality [AAPC = −0.4%, 95% CI (−0.7% to −0.1%)] and DALYs rate [AAPC = −0.3%, 95% CI (−0.6% to −0.1%)] of IHD among young adults decreased, while the prevalence rate [AAPC = 0.4%, 95% CI (0.4%–0.4%)] and YLDs rate [AAPC = 0.4%, 95% CI (0.3%–0.4%)] increased. Furthermore, countries with lower levels of socio-demographic index (SDI) disproportionately bore a higher burden of IHD among young adults. The inequality slope index for young adult IHD shifted from −56.6 [95% CI (−480.4–370.2)] in 1990 to −583.0 [95% CI (−996.8 to −169.2)] in 2019, and the concentration index moved from −8.2 [95% CI (−8.5 to −7.9)] in 1990 to −13.2 [95% CI (−13.9 to −12.4)] in 2019.ConclusionsWhile the mortality and DALYs rate of IHD among global young adults have decreased over the past 30 years, the degree of inequality related to SDI among countries has continued to increase. Decision-makers in various countries should allocate resources wisely and implement effective strategies to improve the burden of young adults IHD globally and address the health inequalities associated with it.</p

Datasheet7_Global burden, trends, and inequalities of ischemic heart disease among young adults from 1990 to 2019: a population-based study.csv

BackgroundIschemic heart disease (IHD) is a major global health concern, and its burden among young adults aged 25–49 years remains underexplored. This study aims to provide a comprehensive assessment of the global burden and trends of IHD over the past 30 years (1990–2019) among this age group, as well as to analyze the health inequalities related to socioeconomic development.MethodsData from Global Burden of Disease Study 2019 (GBD 2019) were utilized to analyze the prevalence, mortality, and disability-adjusted life years (DALYs) rate of IHD among young adults globally. Joinpoint regression analysis was applied to examine the trends over the study period. Health inequality analysis was performed to investigate the disparities in IHD burden related to the Socio-Demographic Index (SDI) of countries.ResultsAccording to GBD 2019 data, in 2019, the global numbers of young adults with IHD cases, deaths, and DALYs were 18,050,671 (95% UI, 15,551,940–21,254,746), 597,137 (548,250–647,778), and 28,692,968 (26,397,448–31,178,464), respectively, accounting for 9.15%, 6.53%, and 15.7% of the total global cases. Over the past 30 years, the mortality [AAPC = −0.4%, 95% CI (−0.7% to −0.1%)] and DALYs rate [AAPC = −0.3%, 95% CI (−0.6% to −0.1%)] of IHD among young adults decreased, while the prevalence rate [AAPC = 0.4%, 95% CI (0.4%–0.4%)] and YLDs rate [AAPC = 0.4%, 95% CI (0.3%–0.4%)] increased. Furthermore, countries with lower levels of socio-demographic index (SDI) disproportionately bore a higher burden of IHD among young adults. The inequality slope index for young adult IHD shifted from −56.6 [95% CI (−480.4–370.2)] in 1990 to −583.0 [95% CI (−996.8 to −169.2)] in 2019, and the concentration index moved from −8.2 [95% CI (−8.5 to −7.9)] in 1990 to −13.2 [95% CI (−13.9 to −12.4)] in 2019.ConclusionsWhile the mortality and DALYs rate of IHD among global young adults have decreased over the past 30 years, the degree of inequality related to SDI among countries has continued to increase. Decision-makers in various countries should allocate resources wisely and implement effective strategies to improve the burden of young adults IHD globally and address the health inequalities associated with it.</p

Datasheet2_Global burden, trends, and inequalities of ischemic heart disease among young adults from 1990 to 2019: a population-based study.csv

BackgroundIschemic heart disease (IHD) is a major global health concern, and its burden among young adults aged 25–49 years remains underexplored. This study aims to provide a comprehensive assessment of the global burden and trends of IHD over the past 30 years (1990–2019) among this age group, as well as to analyze the health inequalities related to socioeconomic development.MethodsData from Global Burden of Disease Study 2019 (GBD 2019) were utilized to analyze the prevalence, mortality, and disability-adjusted life years (DALYs) rate of IHD among young adults globally. Joinpoint regression analysis was applied to examine the trends over the study period. Health inequality analysis was performed to investigate the disparities in IHD burden related to the Socio-Demographic Index (SDI) of countries.ResultsAccording to GBD 2019 data, in 2019, the global numbers of young adults with IHD cases, deaths, and DALYs were 18,050,671 (95% UI, 15,551,940–21,254,746), 597,137 (548,250–647,778), and 28,692,968 (26,397,448–31,178,464), respectively, accounting for 9.15%, 6.53%, and 15.7% of the total global cases. Over the past 30 years, the mortality [AAPC = −0.4%, 95% CI (−0.7% to −0.1%)] and DALYs rate [AAPC = −0.3%, 95% CI (−0.6% to −0.1%)] of IHD among young adults decreased, while the prevalence rate [AAPC = 0.4%, 95% CI (0.4%–0.4%)] and YLDs rate [AAPC = 0.4%, 95% CI (0.3%–0.4%)] increased. Furthermore, countries with lower levels of socio-demographic index (SDI) disproportionately bore a higher burden of IHD among young adults. The inequality slope index for young adult IHD shifted from −56.6 [95% CI (−480.4–370.2)] in 1990 to −583.0 [95% CI (−996.8 to −169.2)] in 2019, and the concentration index moved from −8.2 [95% CI (−8.5 to −7.9)] in 1990 to −13.2 [95% CI (−13.9 to −12.4)] in 2019.ConclusionsWhile the mortality and DALYs rate of IHD among global young adults have decreased over the past 30 years, the degree of inequality related to SDI among countries has continued to increase. Decision-makers in various countries should allocate resources wisely and implement effective strategies to improve the burden of young adults IHD globally and address the health inequalities associated with it.</p

Datasheet3_Global burden, trends, and inequalities of ischemic heart disease among young adults from 1990 to 2019: a population-based study.csv

BackgroundIschemic heart disease (IHD) is a major global health concern, and its burden among young adults aged 25–49 years remains underexplored. This study aims to provide a comprehensive assessment of the global burden and trends of IHD over the past 30 years (1990–2019) among this age group, as well as to analyze the health inequalities related to socioeconomic development.MethodsData from Global Burden of Disease Study 2019 (GBD 2019) were utilized to analyze the prevalence, mortality, and disability-adjusted life years (DALYs) rate of IHD among young adults globally. Joinpoint regression analysis was applied to examine the trends over the study period. Health inequality analysis was performed to investigate the disparities in IHD burden related to the Socio-Demographic Index (SDI) of countries.ResultsAccording to GBD 2019 data, in 2019, the global numbers of young adults with IHD cases, deaths, and DALYs were 18,050,671 (95% UI, 15,551,940–21,254,746), 597,137 (548,250–647,778), and 28,692,968 (26,397,448–31,178,464), respectively, accounting for 9.15%, 6.53%, and 15.7% of the total global cases. Over the past 30 years, the mortality [AAPC = −0.4%, 95% CI (−0.7% to −0.1%)] and DALYs rate [AAPC = −0.3%, 95% CI (−0.6% to −0.1%)] of IHD among young adults decreased, while the prevalence rate [AAPC = 0.4%, 95% CI (0.4%–0.4%)] and YLDs rate [AAPC = 0.4%, 95% CI (0.3%–0.4%)] increased. Furthermore, countries with lower levels of socio-demographic index (SDI) disproportionately bore a higher burden of IHD among young adults. The inequality slope index for young adult IHD shifted from −56.6 [95% CI (−480.4–370.2)] in 1990 to −583.0 [95% CI (−996.8 to −169.2)] in 2019, and the concentration index moved from −8.2 [95% CI (−8.5 to −7.9)] in 1990 to −13.2 [95% CI (−13.9 to −12.4)] in 2019.ConclusionsWhile the mortality and DALYs rate of IHD among global young adults have decreased over the past 30 years, the degree of inequality related to SDI among countries has continued to increase. Decision-makers in various countries should allocate resources wisely and implement effective strategies to improve the burden of young adults IHD globally and address the health inequalities associated with it.</p

The photograph of adult <i>D</i>. <i>pulex</i> female.

<p>The photograph of adult <i>D</i>. <i>pulex</i> female.</p