Visualization 3

In vivo imaging of volunteers attempting to find epithelial cells. Despite the lower reflectivity of the cells due to the illumination wavelength, we can identify some structure candidates of the cells even at real-time display

Visualization 1

Ex vivo corneoscleral wedges imaging the posterior cornea, trabecular mesh, and endothelial cell

Visualization 2

In vivo imaging of volunteers. Real-time imaging of the keratocyte layer is demonstrated without additional stabilization. Nerve fibers can be tracked during the live image session

Visualization 4

In vivo imaging of volunteers' blood vessel structures of the sclera

Panretinal handheld OCT angiography for pediatric retinal imaging

Comprehensive visualization of retina morphology is essential in the diagnosis and management of retinal diseases in pediatric populations. Conventional imaging techniques often face challenges in effectively capturing the peripheral retina, primarily due to the limitations in current optical designs, which lack the necessary field of view to characterize the far periphery. To address this gap, our study introduces a novel ultra-widefield optical coherence tomography angiography (OCTA) system. This system, specifically tailored for pediatric applications, incorporates an ultrahigh-speed 800 kHz swept-source laser. The system’s innovative design achieves a 140° field of view while maintaining excellent optical performance. Over the last 15 months, we have conducted 379 eye examinations on 96 babies using this system. It demonstrates marked efficacy in the diagnosis of retinopathy of prematurity, providing detailed and comprehensive peripheral retinal angiography. The capabilities of the ultra-widefield handheld OCTA system in enhancing the clarity and thoroughness of retina vascularization assessments have significantly improved the precision of diagnoses and the customization of treatment strategies. Our findings underscore the system’s potential to advance pediatric ophthalmology and broaden the scope of retinal imaging