A basket trial design based on constrained hierarchical Bayesian model for latent subgroups

It is well known a basket trial consisting of multiple cancer types has the potential of borrowing strength across the baskets defined by the cancer types, leading to an efficient design in terms of sample size and trial duration. The treatment effects in those baskets are often heterogeneous and categorized by the cancer types being sensitive or insensitive to the treatment. Hence, the assumption of exchangeability in many existing basket trials may be violated, and there is a need to design trials without this assumption. In this paper, we simplify the constrained hierarchical Bayesian model for latent subgroups (CHBM-LS) for two classifiers to deal with the potential heterogeneity of treatment effects due to the single classifier of the cancer type. Different baskets are aggregated into subgroups using a latent subgroup modeling approach. The treatment effects are similar and exchangeable to facilitate information borrowing within each latent subgroup. Applying the simplified CHBM-LS approach to the real basket trials where baskets defined by only cancer types shows better performance than other available approaches. Further simulation study also demonstrates this CHBM-LS approach outperforms other approaches with higher statistical power and better-controlled type I error rates under various scenarios.</p

Map of sampling localities and allele frequencies at locus H16.

<p>Sample numbers match those in Table 1. Pie charts denote allele frequencies at H16, in which each color represents one allele identity. Well supported and less well supported barriers to gene flow based on neutral microsatellites are also shown with broken lines that are proportional to replicates support. The sea areas are shown in abbreviations corresponding to Table 1. The southward China Coastal Cold Current and northward Taiwan Warm Current are also shown with arrows. </p

PCA plotting of population differentiation based on (a) neutral microsatellites; (b) locus H16; (c) locus HSP27.

<p>PCA plotting of population differentiation based on (a) neutral microsatellites; (b) locus H16; (c) locus HSP27.</p

Results of the outlier tests using BAYESCAN.

<p>Loci identified as significant outliers under the decisive criterion of Jeffrey’s interpretation are denoted as solid circles.</p

Plotting results of the program STRUCTURE for neutral loci with K ranging from 3 to 5 and for whole data set with K from 2 to 4, respectively.

<p>Sample identities and its corresponding geographical regions are also showed. </p

Similar Improvements in Patient-reported Outcomes among Rheumatoid Arthritis Patients Treated with two Different Doses of Methotrexate in Combination with Adalimumab: Results from the MUSICA Trial

<p><b>Article full text</b></p><p><br></p><p>The full text of this article can be found here<b>.</b> <a href="https://link.springer.com/article/10.1007/s40744-018-0105-7">https://link.springer.com/article/10.1007/s40744-018-0105-7</a></p><p></p><p><br></p><p><b>Provide enhanced content for this article</b></p><p><br></p><p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p><p><br></p><p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p><p><br></p><p>Other enhanced features include, but are not limited to:</p><p><br></p><p>• Slide decks</p><p>• Videos and animations</p><p>• Audio abstracts</p><p> </p><p>• Audio slides</p><p> </p><p> </p> <p> </p

Data for suppression of reproductive characteristics of Mikania micrantha by sweet potato competition

Data for the following parameters for Mikania micrantha in experiments when grown with sweet potato in different ratios (each set of parameters on a separate tab on the excel file): flowering phenology, pollinators, flowering characteristics, seeds, populatio

Comparison of resistant percentage of IL-E1454 and 10 monogenic lines to 322 <i>Magnaporthe oryzae</i> from 6 countries.

<p>Comparison of resistant percentage of IL-E1454 and 10 monogenic lines to 322 <i>Magnaporthe oryzae</i> from 6 countries.</p

Summary of PCR markers used in this study.

<p>Summary of PCR markers used in this study.</p