2 research outputs found
Ruthenium-Catalyzed Direct Synthesis of Semisaturated Bicyclic Pyrimidines via Selective Transfer Hydrogenation
A new ruthenium-catalyzed
direct and selective synthesis of semisaturated
bicyclic pyrimidines, from α-aminopyridyl alcohols and nitriles,
has been demonstrated. The synthesis proceeds with an easily available
catalyst system, broad substrate scope, excellent functional tolerance,
and no need for high pressure H<sub>2</sub> gas. Control experiments
indicate that the reaction proceeds via successive dehydrogenative
annulation and transfer hydrogenation of the less electrophilic pyridyl
nucleus, and the density functional theory (DFT) study reveals the
origin of such a unique selectivity
Ruthenium-Catalyzed Direct Synthesis of Semisaturated Bicyclic Pyrimidines via Selective Transfer Hydrogenation
A new ruthenium-catalyzed
direct and selective synthesis of semisaturated
bicyclic pyrimidines, from α-aminopyridyl alcohols and nitriles,
has been demonstrated. The synthesis proceeds with an easily available
catalyst system, broad substrate scope, excellent functional tolerance,
and no need for high pressure H<sub>2</sub> gas. Control experiments
indicate that the reaction proceeds via successive dehydrogenative
annulation and transfer hydrogenation of the less electrophilic pyridyl
nucleus, and the density functional theory (DFT) study reveals the
origin of such a unique selectivity