1 research outputs found
Phytomodulatory potential of lycopene from <i style="mso-bidi-font-style:normal">Lycopersicum esculentum</i> against doxorubicin induced nephrotoxicity
635-645An elevated
level of serum urea and creatinine was observed in doxorubicin (DOX) treated
animals indicating
DOX-induced nephrotoxicity. Enhanced lipid peroxidation (LPO) in the renal
tissue was accompanied by a significant decrease in the levels of reduced glutathione (GSH), glutathione peroxidase
(GPx), glutathione reductase (GR) and catalase (CAT) activities. Administration
of lycopene (LycT) extracted from tomato to DOX treated mice showed a
significant reduction in serum creatinine and urea levels which were associated
with significantly low levels of LPO and significantly enhanced level of GSH
and related antioxidant enzymes activity (GPx, GR and CAT) when compared to DOX
group. Histopathological analysis revealed severe damage in the renal tissue of
DOX treated animals. However, animals pretreated with LycT were observed to
have reduced damage. Thus, from present results it may be inferred that
lycopene may be beneficial in mitigating DOX induced nephrotoxicity in mice