Hospital quality, patient risk, and Medicare expenditures for cancer surgery

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142437/1/cncr31120.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142437/2/cncr31120_am.pd

Identifying susceptibility genes for primary ovarian insufficiency on the high-risk genetic background of a fragile X premutation

This is the final version. Available on open access from Elsevier via the DOI in this recordObjective: To identify modifying genes that explains the risk of fragile X-associated primary ovarian insufficiency (FXPOI). Design: Gene-based, case/control association study, followed by a functional screen of highly ranked genes using a Drosophila model. Setting: Participants were recruited from academic and clinical settings. Patient(s): Women with a premutation (PM) who experienced FXPOI at the age of 35 years or younger (n = 63) and women with a PM who experienced menopause at the age of 50 years or older (n = 51) provided clinical information and a deoxyribonucleic acid sample for whole genome sequencing. The functional screen was on the basis of Drosophila TRiP lines. Intervention(s): Clinical information and a DNA sample were collected for whole genome sequencing. Main Outcome Measures: A polygenic risk score derived from common variants associated with natural age at menopause was calculated and associated with the risk of FXPOI. Genes associated with the risk of FXPOI were identified on the basis of the P-value from gene-based association test and an altered level of fecundity when knocked down in the Drosophila PM model. Results: The polygenic risk score on the basis of common variants associated with natural age at menopause explained approximately 8% of the variance in the risk of FXPOI. Further, SUMO1 and KRR1 were identified as possible modifying genes associated with the risk of FXPOI on the basis of an untargeted gene analysis of rare variants. Conclusions: In addition to the large genetic effect of a PM on ovarian function, the additive effects of common variants associated with natural age at menopause and the effect of rare modifying variants appear to play a role in FXPOI risk.Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Fundacion Merck Salu

Orientation Of Carrion Beetles To Carrion Buried Under Shallow Layers Of Sand (Coleoptera, Silphidae)

Volume: 96Start Page: 163End Page: 16

An Inexpensive Carrion Beetle Trap (Coleoptera silphidae)

Volume: 95Start Page: 63End Page: 6

An Ecotonal Study Of Carrion Beetles (Coleoptera, Silphidae) In The Great swamp-National wildlife-Refuge, New jersey

Volume: 104Start Page: 88End Page: 9

Carrion Beetle Responses To Poikilotherm And Homoiotherm Carrion Coleoptera Silphidae

Volume: 87Start Page: 265End Page: 26

Silphids Attracted To Mammal Carrion At Cheltenham, Maryland

Volume: 84Start Page: 409End Page: 41

A List Of Bacterial flora Residing In The Mid And Hindgut Regions Of 6 Species Of Carrion Beetles (Coleoptera, Silphidae)

Volume: 105Start Page: 47End Page: 5

Species Composition And Seasonal Abundance Of Carrion Beetles In An Oak beech Forest In The Great swamp-National wildlife-Refuge (Nj)

Volume: 92Start Page: 7End Page: 1