1 research outputs found
Strontium-Incorporated Carbon Nitride Nanosheets Modulate Intracellular Tension for Reinforced Bone Regeneration
Strontium-containing
agents have been demonstrated to
elicit both
bone anabolic and antiosteoporotic effects, showing great potential
for the treatment of bone loss. However, an increased incidence of
strontium-induced side effects restricts their clinical applications.
Herein, oxidized carbon nitride nanosheets (CN) are delicately used
to incorporate Sr2+ for the first time to achieve high
osteogenic efficacy. The lamellar structure and enriched nitrogen
species of CN provide them with a high surface area-to-volume ratio
and abundant anchoring sites for Sr2+ incorporation. Importantly,
Sr2+-incorporated CN (CNS) could synergistically promote
osteoblast differentiation and bone regeneration at a single, very
low Sr2+ dose. Mechanically, CNS could activate the FAK/RhoA
signaling pathway to modulate the intracellular tension that stimulates
osteoblasts differentiation. The present study will provide a new
paradigm to enhance the efficacy of osteogenic metal ions by using
lamellar nanocarriers