1 research outputs found
α‑Alkylation of Chiral Sulfinimines for Constructing Quaternary Chiral Carbons by Introducing Removable Directing Groups
This
study developed a facile and efficient synthetic strategy
to construct quaternary chiral centers at the α-position of
imines and ketones. High regioselectivity and diastereoselectivity
were achieved through the synergetic effect of electron-withdrawing
directing groups and <i>N</i>-<i>tert</i>-butyl
sulfinamide as chiral auxiliaries. Either of them could be removed
under the optimized conditions without any epimerization