102 research outputs found
Block-block entanglement and quantum phase transitions in one-dimensional extended Hubbard model
In this paper, we study block-block entanglement in the ground state of
one-dimensional extended Hubbard model. Our results show that the phase diagram
derived from the block-block entanglement manifests richer structure than that
of the local (single site) entanglement because it comprises nonlocal
correlation. Besides phases characterized by the charge-density-wave, the
spin-density-wave, and phase-separation, which can be sketched out by the local
entanglement, singlet superconductivity phase could be identified on the
contour map of the block-block entanglement. Scaling analysis shows that behavior of the block-block entanglement may exist in both
non-critical and the critical regions, while some local extremum are induced by
the finite-size effect. We also study the block-block entanglement defined in
the momentum space and discuss its relation to the phase transition from
singlet superconducting state to the charge-density-wave state.Comment: 8 pages, 9 figure
Entanglement and quantum phase transition in the extended Hubbard model
We study quantum entanglement in one-dimensional correlated fermionic system.
Our results show, for the first time, that entanglement can be used to identify
quantum phase transitions in fermionic systems.Comment: 5 pages, 4 figure
Fermionic concurrence in the extended Hubbard dimer
In this paper, we introduce and study the fermionic concurrence in a two-site
extended Hubbard model. Its behaviors both at the ground state and finite
temperatures as function of Coulomb interaction (on-site) and
(nearest-neighbor) are obtained analytically and numerically. We also
investigate the change of the concurrence under a nonuniform field, including
local potential and magnetic field, and find that the concurrence can be
modulated by these fields.Comment: 5 pages, 7 figure
Intratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response
Bacterial genome is characterized by frequent unmethylated cytosine-phosphate-guanine (CpG) motifs. Deleterious effects can occur when synthetic oligodeoxynucleotides (ODN) with unmethylated CpG dinucleotides (CpG-ODN) are administered in a systemic fashion. We aimed to evaluate the effect of intratracheal CpG-ODN on lung inflammation and systemic inflammatory response. C57BL/6J mice received intratracheal administration of CpG-ODN (0.01, 0.1, 1.0, 10, or 100 μM) or control ODN without CpG motif. Bronchoalveolar lavage (BAL) fluid was obtained 3 or 6 h or 1, 2, 7, or 14 days after the instillation and subjected to a differential cell count and cytokine measurement. Lung permeability was evaluated as the BAL fluid-to-plasma ratio of the concentration of human serum albumin that was injected 1 h before euthanasia. Nuclear factor (NF)-κB DNA binding activity was also evaluated in lung homogenates. Intratracheal administration of 10 μM or higher concentration of CpG-ODN induced significant inflammatory cell accumulation into the airspace. The peak accumulation of neutrophils and lymphocytes occurred 1 and 2 days after the CpG-ODN administration, respectively. Lung permeability was increased 1 day after the 10 μM CpG-ODN challenge. CpG-ODN also induced nuclear translocation of NF-κB and upregulation of various inflammatory cytokines in BAL fluid and plasma. Histopathology of the lungs and liver revealed acute lung injury and liver damage with necrosis, respectively. Control ODN without CpG motif did not induce any inflammatory change. Since intratracheal CpG-ODN induced acute lung injury as well as systemic inflammatory response, therapeutic strategies to neutralize bacterial DNA that is released after administration of bactericidal agents should be considered
Whole Blood DNA Aberrant Methylation in Pancreatic Adenocarcinoma Shows Association with the Course of the Disease: A Pilot Study
Pancreatic tumors are usually diagnosed at an advanced stage in the progression of the disease, thus reducing the survival chances of the patients. Non-invasive early detection would greatly enhance therapy and survival rates. Toward this aim, we investigated in a pilot study the power of methylation changes in whole blood as predictive markers for the detection of pancreatic tumors. We investigated methylation levels at selected CpG sites in the CpG rich regions at the promoter regions of p16, RARbeta, TNFRSF10C, APC, ACIN1, DAPK1, 3OST2, BCL2 and CD44 in the blood of 30 pancreatic tumor patients and in the blood of 49 matching controls. In addition, we studied LINE-1 and Alu repeats using degenerate amplification approach as a surrogate marker for genome-wide methylation. The site-specific methylation measurements at selected CpG sites were done by the SIRPH method. Our results show that in the patient’s blood, tumor suppressor genes were slightly but significantly higher methylated at several CpG sites, while repeats were slightly less methylated compared to control blood. This was found to be significantly associated with higher risk for pancreatic ductal adenocarcinoma. Additionally, high methylation levels at TNFRSCF10C were associated with positive perineural spread of tumor cells, while higher methylation levels of TNFRSF10C and ACIN1 were significantly associated with shorter survival. This pilot study shows that methylation changes in blood could provide a promising method for early detection of pancreatic tumors. However, larger studies must be carried out to explore the clinical usefulness of a whole blood methylation based test for non-invasive early detection of pancreatic tumors
Dispersive, superfluid-like shock waves in nonlinear optics
In most classical fluids, shock waves are strongly dissipative, their energy
being quickly lost through viscous damping. But in systems such as cold
plasmas, superfluids, and Bose-Einstein condensates, where viscosity is
negligible or non-existent, a fundamentally different type of shock wave can
emerge whose behaviour is dominated by dispersion rather than dissipation.
Dispersive shock waves are difficult to study experimentally, and analytical
solutions to the equations that govern them have only been found in one
dimension (1D). By exploiting a well-known, but little appreciated,
correspondence between the behaviour of superfluids and nonlinear optical
materials, we demonstrate an all-optical experimental platform for studying the
dynamics of dispersive shock waves. This enables us to observe the propagation
and nonlinear response of dispersive shock waves, including the interaction of
colliding shock waves, in 1D and 2D. Our system offers a versatile and more
accessible means for exploring superfluid-like and related dispersive
phenomena.Comment: 21 pages, 6 figures Revised abstrac
Genome-Wide Association Study of Copy Number Variants Suggests LTBP1 and FGD4 Are Important for Alcohol Drinking
Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological dependence on alcohol. AD is reflected by regular alcohol drinking, which is highly inheritable. In this study, to identify susceptibility genes associated with alcohol drinking, we performed a genome-wide association study of copy number variants (CNVs) in 2,286 Caucasian subjects with Affymetrix SNP6.0 genotyping array. We replicated our findings in 1,627 Chinese subjects with the same genotyping array. We identified two CNVs, CNV207 (combined p-value 1.91E-03) and CNV1836 (combined p-value 3.05E-03) that were associated with alcohol drinking. CNV207 and CNV1836 are located at the downstream of genes LTBP1 (870 kb) and FGD4 (400 kb), respectively. LTBP1, by interacting TGFB1, may down-regulate enzymes directly participating in alcohol metabolism. FGD4 plays a role in clustering and trafficking GABAA receptor and subsequently influence alcohol drinking through activating CDC42. Our results provide suggestive evidence that the newly identified CNV regions and relevant genes may contribute to the genetic mechanism of alcohol dependence
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