2 research outputs found
The Synthesis and Biological Activities of [5-(4-Substituted Phenylsulfinyl/Sulfonyl)-1,3-Dimethyl-1<i>H</i>-Pyrazol-4-Yl]-Arylmethanones
<div><p></p><p>A novel series of pyrazole derivatives containing substituted phenylsulfinyl/sulfonyl group have been synthesized via the oxidation of intermediate pyrazole sulfoether with H<sub>2</sub>O<sub>2</sub> in acetic acid. The novel compounds were characterized by melting point, <sup>1</sup>H NMR, FT-IR, MS, and elemental analysis or HRMS. The biological activity results showed that most of the title compounds exhibit significant fungicidal activities against Alternaria solani Sorauer, Phytophthora capsici, and Corynespora cassiicola.</p>
<p>[Supplementary materials are available for this article. Go to the publisher's online edition of <i>Phosphorus, Sulfur, and Silicon and the Related Elements</i> for the following free supplemental files: Additional text and figures.]</p>
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Novel Ultrasound-Promoted Parallel Synthesis of Trifluoroatrolactamide Library via a One-Pot Passerini/Hydrolysis Reaction Sequence and Their Fungicidal Activities
An ultrasound-promoted one-pot Passerini/hydrolysis
reaction sequence has been developed for the synthesis of trifluoroatrolactamide
derivatives using a diverse range of trifluoroacetophenones and isonitriles
in acetic acid. Parallel synthesis in a centrifuge tube using a noncontact
ultrasonic cell crusher was used in this study as an efficient method
for the rapid generation of combinatorial trifluoroatrolactamide libraries,
and subsequent biochemical evaluation of the resulting compounds indicated
that they possessed excellent broad-spectrum fungicidal activities. <i>N</i>-(4-chlorophenyl)-2-(4-ethylphenyl)-3,3,3-trifluoro-2-hydroxypropanamide
and <i>N</i>-(4-chlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propanamide,
in particular, showed significant fungicidal activities against all
of the fungal species tested in the current study