An Ideal Approach for Detection and Prevention of Phishing Attacks

AbstractPhishing is a treacherous attempt to embezzle personal information such as bank account details, credit card information, social security number, employment details, and online shopping account passwords and so on from internet users. Phishing, or stealing of sensitive information on the web, has dealt a major blow to Internet security in recent times. These attacks use spurious emails or websites designed to fool users into divulging personal financial data by emulating the trusted brands of well-known banks, e-commerce and credit card companies.In this paper, we propose a phishing detection and prevention approach combining URL-based and Webpage similarity based detection. URL-based phishing detection involves extraction of actual URL (to which the website is actually directed) and the visual URL (which is visible to the user). LinkGuard Algorithm is used to analyze the two URLs and finally depending on the result produced by the algorithm the procedure proceeds to the next phase. If phishing is not detected or Phishing possibility is predicted in URL-based detection, the algorithm proceeds to the visual similarity based detection. A novel technique to visually compare a suspicious page with the legitimate one is presented

Evaluation of the Efficacy of a New Dichoptic Digital Platform to Treat the Anisometropic and Isometropic Amblyopia

The aim of the current study was to evaluate the results of a novel dichoptic training program using an online platform in a group of subjects with refractive amblyopia, performing a comparative analysis of unilateral and bilateral amblyopic cases. For this purpose, a retrospective study analysis of data of 161 children (4–13 years) who underwent dichoptic treatment with the Bynocs® platform (Kanohi Eye Pvt. Ltd., India) was performed. In all cases, the therapy protocol consisted of sessions of training of 30 min daily 5 times a week for 6 weeks. Best corrected visual acuity (BCVA) in the non-dominant eye improved significantly with the treatment, with a mean change of 0.39 logMAR in the whole sample (p < 0.001). Regarding binocularity, the binocular function (BF) score also experienced a significant improvement (p < 0.001), with a mean change of 1.55 with therapy in the whole sample. The BCVA of the dominant eye only improved significantly (p < 0.001) in the isometropic amblyopic subgroup. In conclusion, the use of the dichoptic therapy with the digital platform evaluated allows an effective restoration of visual acuity and binocular function in children with anisometropic and isometropic amblyopia.The author David P Piñero has been supported by the Ministry of Economy, Industry and Competitiveness of Spain within the program Ramón y Cajal, RYC‐2016‐20471

Comparative Evaluation of the Complementary and Alternative Medicine Therapy and Conventional Therapy Use for Musculoskeletal Disorders Management and Its Association with Job Satisfaction among Dentists of West India

ABSTRACTMusculoskeletal problems have become a significant issue in the profession of dentistry. There are currently no recommended effective disease-preventing and modifying remedies. High prevalence rates for musculoskeletal disorders (MSDs) among dentists have been reported in the literature. Complementary and alternative medicine can be helpful in managing and preventing the MSDs. The purpose of this study was to determine if dentists in the western part of India are using complementary and alternative medicine therapies for MSDs, and also to find if those who use complementary and alternative medicine therapies have greater job/career satisfaction compared to conventional therapy (CT) users. Dentists of western India registered under the Dental Council of India (N=2166) were recruited for the study. Data were analyzed using univariate and bivariate analyses and logistic regression. A response rate of 73% (n=1581) was obtained, of which 79% (n=1249) was suffering from MSDs. The use of complementary and alternative medicine or CT was reported by 90% (n=1124) of dentists with MSDs. Dentists using complementary and alternative medicine reported greater health (P<0.001) and carrier satisfaction (P<0.001) and were able to work as many hours they wanted (P<0.001) compared to CT users. Complementary and alternative medicine therapies may improve the quality of life and enhance job satisfaction for a dentist who suffers from MSDs

Knockout of angiotensin converting enzyme-2 receptor leads to morphological aberrations in rodent olfactory centers and dysfunctions associated with sense of smell

Neuronal morphological characterization and behavioral phenotyping in mouse models help dissecting neural mechanisms of brain disorders. Olfactory dysfunctions and other cognitive problems were widely reported in asymptomatic carriers and symptomatic patients infected with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This led us to generate the knockout mouse model for Angiotensin Converting Enzyme-2 (ACE2) receptor, one of the molecular factors mediating SARS-CoV-2 entry to the central nervous system, using CRISPR-Cas9 based genome editing tools. ACE2 receptors and Transmembrane Serine Protease-2 (TMPRSS2) are widely expressed in the supporting (sustentacular) cells of human and rodent olfactory epithelium, however, not in the olfactory sensory neurons (OSNs). Hence, acute inflammation induced changes due to viral infection in the olfactory epithelium may explain transient changes in olfactory detectabilities. As ACE2 receptors are expressed in different olfactory centers and higher brain areas, we studied the morphological changes in the olfactory epithelium (OE) and olfactory bulb (OB) of ACE2 KO mice in comparison with wild type animals. Our results showed reduced thickness of OSN layer in the OE, and a decrease in cross-sectional area of glomeruli in the OB. Aberrations in the olfactory circuits were revealed by lowered immunoreactivity toward microtubule associated protein 2 (MAP2) in the glomerular layer of ACE2 KO mice. Further, to understand if these morphological alterations lead to compromised sensory and cognitive abilities, we performed an array of behavioral assays probing their olfactory subsystems’ performances. ACE2 KO mice exhibited slower learning of odor discriminations at the threshold levels and novel odor identification impairments. Further, ACE2 KO mice failed to memorize the pheromonal locations while trained on a multimodal task implying the aberrations of neural circuits involved in higher cognitive functions. Our results thus provide the morphological basis for the sensory and cognitive disabilities caused by the deletion of ACE2 receptors and offer a potential experimental approach to study the neural circuit mechanisms of cognitive impairments observed in long COVID

A multi-centric, single-blinded, randomized, parallel-group study to evaluate the effectiveness of nasoalveolar moulding treatment in non-syndromic patients with complete unilateral cleft lip, alveolus and palate (NAMUC study): a study protocol for a randomized controlled trial.

BACKGROUND Cleft lip and palate (CLP) are among the most common congenital anomaly that affects up to 33,000 newborns in India every year. Nasoalveolar moulding (NAM) is a non-surgical treatment performed between 0 and 6 months of age to reduce the cleft and improve nasal aesthetics prior to lip surgery. The NAM treatment has been a controversial treatment option with 51% of the cleft teams in Europe, 37% of teams in the USA and 25 of cleft teams in India adopting this methodology. This treatment adds to the already existing high burden of care for these patients. Furthermore, the supporting evidence for this technique is limited with no high-quality long-term clinical trials available on the effectiveness of this treatment. METHOD The NAMUC study is an investigator-initiated, multi-centre, single-blinded randomized controlled trial with a parallel group design. The study will compare the effectiveness of NAM treatment provided prior to lip surgery against the no-treatment control group in 274 patients with non-syndromic unilateral complete cleft lip and palate. The primary endpoint of the trial is the nasolabial aesthetics measured using the Asher McDade index at 5 years of age. The secondary outcomes include dentofacial development, speech, hearing, cost-effectiveness, quality of life, patient perception, feeding and intangible benefits. Randomization will be carried out via central online system and stratified based on cleft width, birth weight and clinical trial site. DISCUSSION We expect the results from this study on the effectiveness of treatment with NAM appliance in the long term along with the cost-effectiveness evaluation can eliminate the dilemma and differences in clinical care across the globe. TRIAL REGISTRATION ClinicalTrials.gov CTRI/2022/11/047426 (Clinical Trials Registry India). Registered on 18 November 2022. The first patient was recruited on 11 December 2022. CTR India does not pick up on Google search with just the trial number. The following steps have to be carried out to pick up. How to search: ( https://ctri.nic.in/Clinicaltrials/advsearch.php -use the search boxes by entering the following details: Interventional trial > November 2022 > NAMUC)

Creating Signed Language Resources to Increase Access and Representation of the Deaf Community and Advance Sign Language-Centered Research

Creating high-quality resources that are easily accessible in Sign Language (SL) is important and valuable to the Deaf community. It is essential to embed videos created by SL-fluent experts using high-quality cameras for producing understandable content into digital resources in a manner that ensures users can access them seamlessly on their screens and devices. Simply adding videos to an user interface design that is optimized for English leads to unsatisfactory results because language conventions and differences in intuition create varying scanning patterns and expectations regarding the information’s placement and presentation. Therefore, design choices regarding the videos and their surroundings must be made to overcome this challenge. By promoting the widespread use and availability of well-designed SL resources, this work supports increased access and representation of SL online materials for members of the Deaf community. We studied design elements that can help users navigate resources intuitively without relying on English. We developed an SL-centric survey tool that enables users to create and answer surveys in SL. This contributes to creating design paradigms and guidelines for SL interfaces. Lastly, we contribute to cultivating access to collaborative human-centered methods and research by closely reflecting on our methods and moving towards creating a guideline to carry out research in SL

The Influence of Automated Narrative Feedback on Student-Designed Gamified Research

Automated feedback has the potential to provide significant assistance to student game creators. We present a system for generating automated, critique-like feedback for students creating games in the StudyCrafter platform. We implemented a system that builds a personalized feedback report for students based on a templated format. This critique uses automated analysis of structural and interactive aspects of the game narrative and recommends alternate games for students to examine as inspiration. We investigate the impact of automatically-generated formative assessment on students' design process and educational experience. We present the results of two studies conducted in different University classrooms where students were tasked with creating virtual experiments using a narrative game creation tool with different learning goals in both cases. The first study involved providing automated feedback to 10 student groups for the narrative-based games they developed as a part of a psychology class to learn about research methods. The second study was conducted across two course sections, in which one course section received automated feedback for their games' narrative design, and the other section did not. Our results reveal that students who received AI-generated feedback actively engaged with the feedback system. We further find that their projects developed more over time in regard to their narrative design