Синтез и характеристика фотоактивных арилазидных производных пептидов семакса и Pro-Gly-Pro

The photoaffine arylazide derivatives of peptides semax and Pro-Gly-Pro have been synthesized. It was shown that these compounds have cytoptotective action in culture of PC12 cells under conditions of oxidative stress.Осуществлен синтез п-азидотетрафторбензойных производных пептидов семакса и Pro-Gly-Pro. Показано, что полученные фотоаффинные арилазидные зонды обладают цтопротективным действием на культивируемые клетки PC12 в условиях окислительного процесс

THE STUDY OF STABILITY AND DETERMINATION OF THE STORAGE CONDITIONS AND THE SHELF LIFE OF THE OINTMENT “ESTAN”

The aim of the work. To study stability of the ointment “Estan” in the process of storage and determine the storage conditions and its shelf life. Materials and Methods. The study object was the ointment “Estan” containing lidocaine hydrochloride and the extract of oak bark and horse chestnut seed in the hydrophilic polyethylene oxide base for treating hemorrhoid. During storage of the samples of the ointment we studied such indicators as appearance, uniformity, the weight of the container content and its integrity, рН, particle size, the quantitative content of tannin, escin, lidocaine hydrochloride, and preservatives, microbiological purity were determined by physical, physicochemical, microbiological and pharmacotechnological methods according to the requirements of the State Pharmacopoeia of Ukraine (SPhU). Results and Discussion. The results of the conducted studies showed that the ointment “Estan” is stable when stored in a dry cool place protected from light for 2 years. The storage at room temperature resulted in an insignifi cant pH increase. Conclusions. The study of stability of the ointment “Estan” for treating hemorrhoid in the process of storage was conducted. It was experimentally proven that all indicators of the product quality meet the requirements of the draft for quality control methods. The storage conditions for the ointment “Estan”, namely in a dry dark cool place for 2 years, were determined

Synthesis and characteristic of photoactive arylazide semax and pro-gly-pro peptide derivatives.

The photoaffine arylazide derivatives of peptides semax and Pro-Gly-Pro have been synthesized. It was shown that these compounds have cytoptotective action in culture of PC12 cells under conditions of oxidative stress

Control of the process of wear of the tribosystems based on the optical density of the lubricating oil using neural network models

The article considers the task of studying how the two processes relate - the destruction of lubricating oil and the wear of the elements of the tribosystem. The paper analyzes one of these indicators - the optical density of the oil, which characterizes the process of its destruction. The study includes the stage of constructing multifactor intelligent critical wear models depending on the optical density of the oil and the effort in the friction pair. The initial data for the construction of models are the results of measurements of the optical density of oils and the diameter of the wear spot. The obtained forecast models are indispensable for explaining the fundamental processes of wear that occur during the operation of lubricating oil. In addition to this, it should be noted that the results obtained make it possible to take the next step towards the creation of a new technique for the rapid assessment of the state of lubricating oil and the corresponding nature of the process of wear of the tribosystem