Towards integrated Intranet services : modeling the costs of corporate IP technology

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.Includes bibliographical references (p. 64-66).by Kristin Ilene Short.M.S

The Grizzly, January 31, 2008

What\u27s Your Dirty Little Secret? RLO Posts Free Speech • Focus the Nation Events Begin Today at Ursinus College • Writers Continue to Protest Insufficient Compensation • New Statistics Reveal Decline in U.S. Abortion Rates • New Member Education is Not Your Enemy • UC Gives Tribute to MLK Jr. • Middlesex, by Jeffrey Eugenides • Opinions: Return of Information Society; Honoring Dr. Martin Luther King from Home; John Edwards: Wasting His (And Our) Time • Gymnastics Off to a Strong Start • Shattuck Helps Lead the Bears to Victoryhttps://digitalcommons.ursinus.edu/grizzlynews/1753/thumbnail.jp

The Grizzly, April 3, 2008

Crude Awakening: Ways to Beat Surging Gas Pump Prices • Airband Turns 25 • Herpes Hindrance: Part Two • Literary Food Fest • Lou\u27s Too: The Charming Steak Shop • Fully Loaded EV Performance Attracts Full House • Faculty Spotlight: Dr. Goldsmith • Opinions: Fed Bailout? Fed, Butt Out!; Olympic Controversy • Men\u27s Lax Defeats McDaniel • Women\u27s Lax Shames McDanielhttps://digitalcommons.ursinus.edu/grizzlynews/1760/thumbnail.jp

The Grizzly, March 6, 2008

President Strassburger\u27s Message to Campus About New Member Education • Students Flock to Ursinus Job and Internship Fair • SIFE: An Organization Suited for All Ursinus Majors • The Real Inspector Hound: Stoppard Performed at UC • Local Venues Offer Break Options • Ursinus Fraternities Participate in Community Service • Da Vinci\u27s Pub: Are You a Renaissance Man or Woman? • Opinions: Anthony\u27s Keys to Making Friends; Academic Integrity for the Rest of Us; Rethinking the Second Amendment: What Does it Protect? • Football Coach Kevin Barger Moving On • Congrats to the 2008 Centennial Conference Champs! • Baseball and Softball Aim to Hit it Out of the Park • Two Head to Wrestling Nationalshttps://digitalcommons.ursinus.edu/grizzlynews/1758/thumbnail.jp

The Grizzly, March 27, 2008

Escape Velocity Dance Troupe Gets Fully Loaded • Habitat for Humanity: Community Service with a Tan • Ways to Prepare for Fall Housing and Room Selection • Religion on Campus: Hillel, MSA, IV and More! • Herpes Hindrance: Part One • Fox and Hound Pub and Grill: Which One are You? • Ursinus Sororities Participate in Community Service • Scientific Look at the Truth is Beauty Equation • Quick Glance at Upcoming CAB and RHA Events • Myrin\u27s Edible Books Festival: Battle of the Most Literate Foods • Opinions: Pledge to Darfur; Vice Presidential Possibilities: Let\u27s Start the Speculation • A Magical Season • Bears Dominate ECAC Championships • Ursinus Tennis Teams Hope to Rack Up a Good Seasonhttps://digitalcommons.ursinus.edu/grizzlynews/1759/thumbnail.jp

The Grizzly, November 26, 1991

Alcohol Speaker • Hostage Update • Wallace Speaks to Whitians • Barry M. Goldwater Scholarship and Excellence in Education Foundation Program • Keepers of the Flame : King Speaks on Soviet Art • Concert Band & Jazz Ensemble Perform • Reader\u27s Theatre on Soviet Art • John Updike to Speak • CAB Entertainers Enthrall All • An Upheaval of Rumors • Movie Review: Home Alone • Is Pretty Good Good Enough? • The World is Not Red, White, and Blue • Letters: Alcove Access; Halloween Flip-Flop; More Response to Ronnig Letter; Administration Woes; Enough Already!; Ronning Responses Critiqued; A Christian Response • Basketball Opens Season with Losses to Dickinson and Cabrini in Tip-Off Tournament • Kershner goes to Nationals • Ursinus Outswims Washington • Women\u27s Soccer Team in the Works • Women Hoopsters Open Season • Lady Bears Sink Competition • Charity Hoops Game • Lacrosse Ends Seasonhttps://digitalcommons.ursinus.edu/grizzlynews/1285/thumbnail.jp

The Grizzly, October 29, 1991

Charles Gibson Speaks to Crowd • Blood Drive a Success • Pledging Ends • Clergy Assembly for Professional Development on Campus Next Week • Hood Speaks on Morals at Tri-Lambda Meeting • The Environmental Corner • The Experience of a Lifetime • Environmental Chemistry and its Price • Trimming the Fat • Snoopy • Berman Opens Two New Exhibits • Dating Game a Success • Carlin Captivates at Valley Forge • ProTheatre Presents ... The Crucible • Haunted Hayride • Silence of the Lambs • Thought Organization • America: A Nation of Sissies • Letters: Clarification of GALA; Put Your Mouth Where Your Money Is • Bears Have a Devil of a Time with FDU • Lady Bears Finish 4th at PAIAW • Field Hockey Sticks it to St. Joe\u27s • Lady \u27Mers Swim to Victory at Ship Relays • Men\u27s Lacrosse Defeats St. Joseph\u27s • Flag Football • Men Swimmers Start Season • Cross Country Runs Widener Ragged • Golf Scores • Farleigh-Dickinson and Haverford Bounce by Ursinushttps://digitalcommons.ursinus.edu/grizzlynews/1281/thumbnail.jp

Consensus Guidelines for Perioperative Care in Neonatal Intestinal Surgery: Enhanced Recovery After Surgery (ERAS\u3csup\u3e®\u3c/sup\u3e) Society Recommendations

Background: Enhanced Recovery After Surgery (ERAS®) Society guidelines integrate evidence-based practices into multimodal care pathways that have improved outcomes in multiple adult surgical specialties. There are currently no pediatric ERAS® Society guidelines. We created an ERAS® guideline designed to enhance quality of care in neonatal intestinal resection surgery. Methods: A multidisciplinary guideline generation group defined the scope, population, and guideline topics. Systematic reviews were supplemented by targeted searching and expert identification to identify 3514 publications that were screened to develop and support recommendations. Final recommendations were determined through consensus and were assessed for evidence quality and recommendation strength. Parental input was attained throughout the process. Results: Final recommendations ranged from communication strategies to antibiotic use. Topics with poor-quality and conflicting evidence were eliminated. Several recommendations were combined. The quality of supporting evidence was variable. Seventeen final recommendations are included in the proposed guideline. Discussion: We have developed a comprehensive, evidence-based ERAS guideline for neonates undergoing intestinal resection surgery. This guideline, and its creation process, provides a foundation for future ERAS guideline development and can ultimately lead to improved perioperative care across a variety of pediatric surgical specialties

The home environment and childhood obesity in low-income households: indirect effects via sleep duration and screen time

Background Childhood obesity disproportionally affects children from low-income households. With the aim of informing interventions, this study examined pathways through which the physical and social home environment may promote childhood overweight/obesity in low-income households. Methods Data on health behaviors and the home environment were collected at home visits in low-income, urban households with either only normal weight (n = 48) or predominantly overweight/obese (n = 55) children aged 6–13 years. Research staff conducted comprehensive, in-person audits of the foods, media, and sports equipment in each household. Anthropometric measurements were collected, and children’s physical activity was assessed through accelerometry. Caregivers and children jointly reported on child sleep duration, screen time, and dietary intake of foods previously implicated in childhood obesity risk. Path analysis was used to test direct and indirect associations between the home environment and child weight status via the health behaviors assessed. Results Sleep duration was the only health behavior associated with child weight status (OR = 0.45, 95% CI: 0.27, 0.77), with normal weight children sleeping 33.3 minutes/day longer on average than overweight/obese children. The best-fitting path model explained 26% of variance in child weight status, and included paths linking chaos in the home environment, lower caregiver screen time monitoring, inconsistent implementation of bedtime routines, and the presence of a television in children’s bedrooms to childhood overweight/obesity through effects on screen time and sleep duration. Conclusions This study adds to the existing literature by identifying aspects of the home environment that influence childhood weight status via indirect effects on screen time and sleep duration in children from low-income households. Pediatric weight management interventions for low-income households may be improved by targeting aspects of the physical and social home environment associated with sleep

Characterization of BRCA1-deficient breast cancer cells with acquired resistance to CHK1 inhibitor therapy

Breast cancer is the second most lethal form of diagnosed cancer in women today. Women who have inherited mutations in the Breast Cancer Associated 1 (BRCA1) gene have a 70-90% chance of developing breast cancer at some point in their lifetime. These cancers are often highly aggressive with very few treatment options. A previously conducted chemical screen indicated that BRCA1 deficient breast cancer cells express an increased sensitivity to drugs that inhibit the cell cycle protein checkpoint kinase 1 (CHK1). CHK1 inhibitors are used clinically in combination with chemotherapeutics and other DNA damaging agents, but BRCA1 deficient breast cancer cells display sensitivity to these drugs as single agents. This gives CHK1 inhibitors promise as a targeted therapy for BRCA! deficient cancers. However, tumor recurrence and resistance to targeted therapies is a growing issue clinically. The purpose of this study was to analyze how initially sensitive cells change upon acquiring resistance to CHK1 inhibitors, and to begin to elucidate possible mechanisms of resistance. It was shown that the resistant cells display and overall decrease in aggressive characteristics when assessing proliferation, migration, colony formation, and mammosphere formation abilities. Phospho-receptor tyrosine kinase and phospho-kinase arrays revealed several signaling pathways that could be conferring resistance to CHK1 inhibitors in these cells, taken together this study gives insight into how cells can change upon acquiring resistance to CHK1 inhibitors and points towards possible mechanisms of resistance. this knowledge is important to understand how CHK1 inhibitors could dbe used clinically, specifically in treating cancers that result from BRCA1 deficiency