13 research outputs found
The relation between significant stenosis or dilatation at the repair site and outcome in a contemporary cohort of patients with repaired aortic coarctation as assessed using Cardiovascular Magnetic Resonance
Aortic root and ascending aortic dilatation in patients with repaired tetralogy of Fallot. Determinants, rates of progression, impacts on outcomes and relations to branch pulmonary artery stenosis
Effect of nitrate supplementation on hepatic blood flow and glucose homeostasis: A double-blind, placebo controlled, randomised control trial.
Nitric oxide alters gastric blood flow, improves vascular function and mediates glucose uptake within the intestines and skeletal muscle. Dietary nitrate, acting as a source of nitric oxide, appears to be a potential low cost therapy that may help maintain glucose homeostasis. In a randomised, double-blind, placebo-controlled crossover study, 31 young and older adult participants had a standardised breakfast, supplemented with either nitrate rich beetroot juice (11.91 mmol nitrate) or nitrate depleted beetroot juice as placebo (0.01 mmol nitrate). MRI was used to assess apparent diffusion coefficient (ADC), portal vein flux and velocity. Plasma glucose, incretin and C-peptide concentrations and BP were assessed. Outcome variables were measured at baseline and hourly for 3 hours. Compared with a placebo, beetroot juice resulted in a significant elevation in plasma nitrate and plasma nitrite concentration. No differences were seen for the young or older adult cohorts between placebo and beetroot juice for ADC, or portal vein flux. There was an interaction effect in the young adults, which was absent in the older adults between visits for portal vein velocity. Nitrate supplementation did not reduce plasma glucose active GLP-1, total GLP-1 or plasma C-peptide concentrations for the young or older adult cohorts. Despite a significant elevation in plasma nitrite concentration following an acute dose of 11.91 mmol of nitrate, there was no effect on hepatic blood flow, plasma glucose, C-peptide, or incretin concentration in healthy adults
Visual Loss Post Ross Procedure in an Adolescent With Newly Diagnosed Mucopolysaccharidosis Type II
Right ventricle anatomy can predict new onset ventricular tachycardia in patients with repaired tetralogy of Fallot
Right ventricle anatomy can predict new onset ventricular tachycardia in patients with repaired tetralogy of Fallot
Dopamine: The kinetics of uptake in the pedal ganglion of Quadrula pustulosa (pelecypoda)
The effect of dietary nitrate supplementation on the oxygen cost of cycling, walking performance and resting blood pressure in individuals with chronic obstructive pulmonary disease: A double blind placebo controlled, randomised control trial
BACKGROUND: Chronic obstructive pulmonary disease (COPD) results in exercise intolerance. Dietary nitrate supplementation has been shown to lower blood pressure (BP), reduce the oxygen cost of exercise, and enhance exercise tolerance in healthy volunteers. This study assessed the effects of dietary nitrate on the oxygen cost of cycling, walking performance and BP in individuals with mild-moderate COPD. METHODS: Thirteen patients with mild-moderate COPD were recruited. Participants consumed 70 ml of either nitrate-rich (6.77 mmol nitrate; beetroot juice) or nitrate-depleted beetroot juice (0.002 mmol nitrate; placebo) twice a day for 2.5 days, with the final supplement ~3 hours before testing. BP was measured before completing two bouts of moderate-intensity cycling, where pulmonary gas exchange was measured throughout. The six-minute walk test (6 MWT) was completed 30 minutes subsequent to the second cycling bout. RESULTS: Plasma nitrate concentration was significantly elevated following beetroot juice vs. placebo (placebo; 48 +/- 86 vs. beetroot juice; 215 +/- 84 microM, P = 0.002). No significant differences were observed between placebo vs. beetroot juice for oxygen cost of exercise (933 +/- 323 vs. 939 +/- 302 ml: min(-1); P = 0.88), distance covered in the 6 MWT (456 +/- 86 vs. 449 +/- 79 m; P = 0.37), systolic BP (123 +/- 14 vs. 123 +/- 14 mmHg; P = 0.91), or diastolic BP (77 +/- 9 vs. 79 +/- 9 mmHg; P = 0.27). CONCLUSION: Despite a large rise in plasma nitrate concentration, two days of nitrate supplementation did not reduce the oxygen cost of moderate intensity cycling, increase distance covered in the 6 MWT, or lower BP