Transportation energy conservation data book edition i 5

This document contains statistical information on the major transportation modes, their respective energy consumption patterns, and other pertinent factors influencing performance in the transportation sector. Data relating to past, present, and projected energy use and conservation in the transportation sector are presented under seven chapter headings. These focus on (1) modal transportation characteristics, (2) energy characteristics of the transportation sector, (3) energy conservation alternatives involving the transportation sector, (4) government impacts on the transportation sector, (5) the supply of energy to the transportation sector, (6) characteristics of transportation demand, and (7) miscellaneous reference materials such as energy conversion factors and geographical maps. References are included for each set of data presented, and a more general bibliography is included at the end of the book. In addition, a glossary of key terms and a subject index is provided for the user. A second edition of this document is scheduled for publication in September 1977. Document type: Repor

Pancytopenia due to iron deficiency worsened by iron infusion: a case report

<p>Abstract</p> <p>Introduction</p> <p>Iron deficiency anemia is commonly associated with thrombocytosis, although thrombocytopenia has been reported in occasional patients with iron-deficiency anemia. Much less common is the development of thrombocytopenia following replenishment of iron stores.</p> <p>Case Presentation</p> <p>We present the unusual case of a 39 year old African American female Jehovah's Witness who presented with a 10 month history of menorrhagia and pancytopenia. Laboratory investigations confirmed a severe iron deficiency. Since blood transfusion was unacceptable to her, she was started on intravenous iron replacement therapy. This precipitated a sudden drop in both her platelet and white blood cell counts. Histopathological examination of the bone marrow revealed a hypercellular marrow with orderly trilineage hematopoiesis, iron deficiency anemia, granulocytic hyperplasia, and mild megakaryocytic hypoplasia. Both her white blood cell and platelet counts recovered uneventfully with continuing iron supplementation. The possible mechanism for this phenomenon is discussed in this report.</p> <p>Conclusion</p> <p>This case illustrates two rather uncommon associations of a very common problem. Severe iron deficiency anemia may be associated with pancytopenia and iron replacement may cause a transient decline in megakaryopoiesis and leukopoiesis. Severe iron deficiency should be added to the list of conditions leading to thrombocytopenia.</p

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

UNLABELLED Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this finding remains unknown. We assessed clinical outcomes, tumor sequencing, and tissue/cerebrospinal fluid (CSF) correlate samples from patients treated in two completed multisite clinical studies. Patients treated with ONC201 following initial radiation but prior to recurrence demonstrated a median overall survival of 21.7 months, whereas those treated after recurrence had a median overall survival of 9.3 months. Radiographic response was associated with increased expression of key tricarboxylic acid cycle-related genes in baseline tumor sequencing. ONC201 treatment increased 2-hydroxyglutarate levels in cultured H3K27M-DMG cells and patient CSF samples. This corresponded with increases in repressive H3K27me3 in vitro and in human tumors accompanied by epigenetic downregulation of cell cycle regulation and neuroglial differentiation genes. Overall, ONC201 demonstrates efficacy in H3K27M-DMG by disrupting integrated metabolic and epigenetic pathways and reversing pathognomonic H3K27me3 reduction. SIGNIFICANCE The clinical, radiographic, and molecular analyses included in this study demonstrate the efficacy of ONC201 in H3K27M-mutant DMG and support ONC201 as the first monotherapy to improve outcomes in H3K27M-mutant DMG beyond radiation. Mechanistically, ONC201 disrupts integrated metabolic and epigenetic pathways and reverses pathognomonic H3K27me3 reduction. This article is featured in Selected Articles from This Issue, p. 2293

Identification of a Carboxyl group at the Active Site of Barley MaIt Phosphatase

The dependence of the maximal velocity, Vm with pH for barley malt phosphatase has been studied from pH 4.0 to 5.4. The data show that an ionizable group in the enzyme-substrate complex with a pK2 of 4-4.6 is important for enzymic activity. These results suggest strongly the involvement of a carboxyl group of a glutamic or aspartic acid residue at the active site of this enzyme

Analysis of the NAFA fleet data base: passenger cars only

To assess the potential market penetration of new vehicular concepts, it is first necessary to determine the current level of demand in terms of physical capabilities and economic constraints. The survey described in this report attempts to measure these characteristics for the fleet market sector in the U.S. The data analyzed come from a survey taken in March 1979 of members of the National Association of Fleet Administrators (NAFA). Each respondent was asked to specify a set of characteristics for electric cars that would meet his specific fleet demands and assign the maximum price he would be willing to pay for each option. From the 139 responses, it is possible to relate the physical specifications of fleet vehicles to economic utility. Two other reports (BNL-51286; BNL-51312) deal with the simulator (CPEN) which was designed by BNL to estimate market penetration rates of new technologies in the fleet market, using the data base described within this report: Joseph R. Wagner, A Method for Estimating TeA methodhnological Penetration Rates in Commercial Automobile Fleets, BNL 51312, May 1980, and Richard Weil, Fleet Car Market Penetration Simulator (CPEN): A User's Guide, BNL 51286, August 1980

Characteristics of automotive fleets in the United States, 1966--1977

Several major areas pertaining to automobile fleet operations in the U.S. are covered. First, all known available sources that contain statistics on fleet vehicles are described. Second, fleet operations in the U.S. are characterized according to stock composition and operational characteristics. Third, properties of fleet cars are compared with those of the total car population, and a comparison is made among fleets used by different sectors. Finally, the significance of fleet operations for transportation energy conservation is discussed

Oak Ridge National Laboratory Reports

Report documenting baseline data for the use in developing a comprehensive strategy for the reduction of energy use in transportation

Characteristics of automotive fleets in the United States : 1966-1977 /

Tables.Prepared for Data Analysis Branch, Office of Conservation, Dept. of Energy under contract no. W-7405-eng-26.Mode of access: Internet