104 research outputs found

    A Study of Faculty Development in Teaching the \u27TOEIC Class\u27 at Tokyo University of Fisheries

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    東京水産大学共通講座東京水産大学共通講座・非常勤講

    Biological Differences Between Ovarian Cancer-associated Fibroblasts and Contralateral Normal Ovary-derived Mesenchymal Stem Cells

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    Background/Aim: The aim of this study was to clarify the biological differences between ovarian cancerassociated fibroblasts (OCa-CAFs) and normal ovary-derived mesenchymal stem cells (NO-MSCs). Materials and Methods: Surgically resected ovarian cancer and contralateral normal ovarian tissue samples were cut into small pieces for culture as “explants”. The number of outgrown cells, their proliferative kinetics, and expression levels of cell surface markers of CAFs, as well as three miRNAs in OCa-CAFs and NO-MSCs were compared directly. Differentially expressed genes between both groups were also investigated. Results: Comparable numbers of outgrown cells were harvested from both groups. Significantly higher expression of α-smooth muscle actin and miR-142 was found in OCa-CAFs, which decreased significantly during ex vivo cell expansion. A total of 21 differentially expressed genes were identified between both groups. Conclusion: OCa-CAFs showed different biological properties in direct comparison with NO-MSCs, which might play major roles in the pathogenesis of ovarian cancer

    A Study on the Theory and Practice of Active Learning Report on the course supported by Learning Assistant ♯7

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    『「恋する学問」は、関西大学の学生科目提案委員という制度を利用して、私たち学生3人が、2年間かけて企画・立案した全学部対象の一般教養科目です。先生や大学職員さんのお力をお借りしながら、シラバス作成から、毎回の授業を90分間どうするかまで自分たちで考えています。授業を創ったきっかけは、3人とも1年生の秋学期に三浦先生の「大学教育論~大学の主人公は君たちだ~」という授業を受講していて、「身の回りにあるものへの知的好奇心」を持った学生が輝ける場所、それが大学なのだということを、もっと自分たちの言葉で伝えていきたいと思ったからです。「もっと知りたい」「もっと自分のことを知ってほしい」と思う好奇心は「恋心」 と同じようなものではないでしょうか。私たちはその「恋心」を学問、チームの仲間、授業、日々の生活など、多くのものにもてるようになることを目的とし、約40人の受講生とともに授業を創り上げています。』 (Field of Invaluable learning 2016*のパンフレットより

    A case of primary breast cancer with chronic phase chronic myelogenous leukemia

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    A female patient in her 40s was admitted because of right breast swelling and pain. She had been taking Nilotinib(a molecular targeted drug)for 4months as treatment for chronic-phase chronic myelogenous leukemia. She was diagnosed with advanced breast cancer by cytology and histological examinations. She received neoadjuvant chemotherapy and had obtained a partial response. She then underwent a nipple-sparing mastectomy and axillary lymph node dissection. Therefore, in this patient, breast cancer and chronic myelogenous leukemia coexisted. Chemotherapy for breast cancer and a molecular targeted drug for chronic-phase chronic myelogenous leukemia were administered concurrently

    Daily calcium intake and physical activity status in urban women living on low incomes in Davao, Philippines : a primary study for osteoporosis prevention

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    Low calcium intake and physical inactivity are modifiable risk factors of osteoporosis ; however, little information is available about the prevalence of these risk factors among urban Filipino women living on low-incomes. The present study, therefore, investigated daily calcium intake, main calcium sources, and physical activity status in this population. The study group comprised healthy women aged in their 30 s who had participated in our previous survey using heel speed of sound (SOS) measurement in Davao, Philippines. The women were stratified into three groups based on SOS score and 20 were randomly selected from each, giving 60 in total. Calcium intake was measured by direct analysis of the food samples collected from 3-days 24 hour-food duplicate method. Physical activity was estimated based on pedometer determined walking steps over 5 days. The median [25%, 75%] calcium intake per day was 289 [225, 434] mg. Traditional foods derived from local small fish and plants were the main calcium sources. The median walking steps per day was 8750 [6920, 10836]. Although three groups did not show significantly different calcium intakes and walking steps, consumption of low-cost small fish and plant foods could be encouraged along with walking in urban Filipino women living on low-incomes

    術後肺ヘルニアに対し,緊急修復手術を施行した1症例

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    A male patient, in his 50s, was admitted owing to rear neck pain and stomachache. He was diagnosed Type A acute aortic dissection and underwent a total arch aortic replacement operation. Five days later, he developed dyspnea after he coughed. He was diagnosed left lung hernia, mediastinal emphysema and pneumothorax by a chest CT scan. We repaired pulmonaly fistula and lung hernia using an ePTFE patch

    甲状腺癌リンパ節転移との鑑別が困難であった頸部神経鞘腫の1例

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    A female patient in her 60s visited her previous doctor because of a right cervical mass that exist for 7 years and gradually increased in size. As she was suspected of cervical lymph node metastasis of thyroid cancer, she was referred to our hospital. At the initial visit, a 5-cm right cervical mass and enlargement of the right lobe of the thyroid gland were observed. Fine needle aspiration cytology was performed on both, but no malignant findings were observed. To confirm the diagnosis and improve the patient’s appearance, a right lobectomy of the thyroid gland and resection of the right cervical mass were performed. A rapid intraoperative histological examination of the cervical mass revealed a schwannoma. The right thyroid tumor was diagnosed as follicular adenoma. Her postoperative course was good, and after several years of follow-up, patient consultation was terminated. Neurolemmoma is a benign tumor arising from Schwann cells in the nerve sheath, and it occurs frequently throughout the head and neck region, with 25%-45% of cases occurring in this region. Cervical schwannomas are characterized by irritation of the vagus nerve, brachial plexus, and sympathetic nerves. However, many patients present with only a painless neck mass, as in this case. Although the mass can be diagnosed by puncture aspiration cytology in some cases, sufficient specimens are often unavailable, and the diagnosis is made preoperatively in about half of all cases. Differential diagnoses of an anterior cervical mass include malignant lymphoma, cervical lymph node metastases of malignant tumors, submandibular gland tumors, and tuberculous lymph node metastases. In this patient, we also considered lymph node metastasis of thyroid cancer. However, a histological examination did not detect malignancy in either the thyroid gland or neck mass, and we considered that the thyroid follicular adenoma and the cervical schwannoma occurred independently. We report our experience of cervical schwannoma combined with thyroid tumor which was suspected of lymph node metastasis of thyroid cancer

    Two cases of pulmonary dirofilariasis

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    Pulmonary dirofilariasis is almost always asymptomatic. An abnormal nodule was accidentally discovered by a chest x-ray during a medical checkup and detailed examination for other diseases was performed. Case 1. A female patient, in her 70s, was admitted owing to flu-like symptoms and bloody sputum. A chest computed tomography(CT)scan revealed a nodular shadow with 10‐mm ground glass opacity in the right lower lobe. Case2. A female patient, in her 60s, was admitted due to an abnormal shadow on a chest xray in the left lung during a regular medical checkup. A chest CT scan revealed a nodular shadow with 13‐mm ground glass opacity in the left upper lobe. Lung cancer was suspected in both cases. Thoracoscopy and partial lung resection were performed to confirm the diagnosis. The specimen consisted of granulation tissue and no malignancy was found at operation. Final pathological diagnosis revealed pulmonary dirofilariasis. Pulmonary dirofilariasis can be definitively diagnosed by detecting a worm body. We believe partial lung resection during video-assisted thoracic surgery is a minimally invasive and an effective treatment for this disease
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