Infectious and non-infectious pericarditis in children

Pericardial diseases in children are heterogeneous in nature and can be both isolated and part of the systemic pathology. Data on the epidemiology and etiology of pericardial disease are contradictory and depend on the hospital profile, patients' age and study aims. Objective of the research-to study modern structure of pericardial diseases in children, clinical and instrumental features of individual forms and treatment tactics in real clinical practice according to the data of the Moscow multi-profile hospital. Study materials and methods: A complex clinical and laboratory-based examination was conducted in 121 patients aged from 1 month to 18 years, admitted to Morozov Children's City Clinical Hospital in Moscow in 2001-2016 with pericardium diseases. Results: pericardium inflammatory lesions were diagnosed in 86% of children, 57% of patients had infectious pericarditis (bacterial and idiopathic). The most severe course was in cases of bacterial, neoplastic pericarditis and postpericardiotomy syndrome (PPTS). A common feature of the severe course was the accumulation of a large pericardial effusion and the threat of a cardiac tamponade. In patients with idiopathic pericarditis and PPTS, herpesvirus infections markers, Mycoplasma pneumoniae, Chlamydophila pneumoniae, were more often detected with large effusions accumulation (p=0,02). Complications development was noted in 33 (27,3%) children: cardiac tamponade or the threat of its development in 23 (19%), recurrent course in 11 (9,1%). As anti-inflammatory therapy non-steroidal anti-inflammatory drugs were used (73,6% of patients); if they were inefficient-glucocorticosteroids (41,3%) and intravenous immunoglobulins (24,8%). Pericardiocentesis due to threat of cardiac tamponade was performed in 13 (10,74%) children. Conclusion: in pericarditis structure dominated infectious: bacterial and idiopathic (57%). Specific IgM antibodies to herpesviruses, Mycoplasma pneumoniae, Chlamydophila pneumoniae are possible markers of large pericardial effusion accumulation children with idiopathic pericarditis and PPTS. To assess the predictors of pericarditis adverse course incl. use of glucocorticosteroids, it is necessary to analyze long-term disease catamnesis. © 2017, Pediatria Ltd. All rights reserved

Infectious and non-infectious pericarditis in children

Pericardial diseases in children are heterogeneous in nature and can be both isolated and part of the systemic pathology. Data on the epidemiology and etiology of pericardial disease are contradictory and depend on the hospital profile, patients' age and study aims. Objective of the research-to study modern structure of pericardial diseases in children, clinical and instrumental features of individual forms and treatment tactics in real clinical practice according to the data of the Moscow multi-profile hospital. Study materials and methods: A complex clinical and laboratory-based examination was conducted in 121 patients aged from 1 month to 18 years, admitted to Morozov Children's City Clinical Hospital in Moscow in 2001-2016 with pericardium diseases. Results: pericardium inflammatory lesions were diagnosed in 86% of children, 57% of patients had infectious pericarditis (bacterial and idiopathic). The most severe course was in cases of bacterial, neoplastic pericarditis and postpericardiotomy syndrome (PPTS). A common feature of the severe course was the accumulation of a large pericardial effusion and the threat of a cardiac tamponade. In patients with idiopathic pericarditis and PPTS, herpesvirus infections markers, Mycoplasma pneumoniae, Chlamydophila pneumoniae, were more often detected with large effusions accumulation (p=0,02). Complications development was noted in 33 (27,3%) children: cardiac tamponade or the threat of its development in 23 (19%), recurrent course in 11 (9,1%). As anti-inflammatory therapy non-steroidal anti-inflammatory drugs were used (73,6% of patients); if they were inefficient-glucocorticosteroids (41,3%) and intravenous immunoglobulins (24,8%). Pericardiocentesis due to threat of cardiac tamponade was performed in 13 (10,74%) children. Conclusion: in pericarditis structure dominated infectious: bacterial and idiopathic (57%). Specific IgM antibodies to herpesviruses, Mycoplasma pneumoniae, Chlamydophila pneumoniae are possible markers of large pericardial effusion accumulation children with idiopathic pericarditis and PPTS. To assess the predictors of pericarditis adverse course incl. use of glucocorticosteroids, it is necessary to analyze long-term disease catamnesis. © 2017, Pediatria Ltd. All rights reserved

Automatic device with servodrive for taking of condensate of options of compressors

Приведен подход к разработке устройств с сервоприводом, позволяющих автоматически сливать конденсат после холодильников ступеней установок компрессорного типа для сжижения паров бензина.Приведений підхід до розробки пристроїв з сервоприводом, що дозволяють автоматично зливати конденсат після холодильників ступенів установок компресорного типу для зріджування пари бензину.Approach is resulted to development of devices with servodrive, allowing automatically to unite condensate after the refrigerators of the stages of options of compressor type for liquefaction of steams of petrol

Mukolipidosis type II as the cause of pulmonary hypertension in children

The article describes the development of multifactorial pulmonary hypertension (PH) associated with hypoxemia on the basis of a long-term clinical observation of the child with type II mucosolipidosis (ML). The literature data on the etiology, pathogenesis, clinical symptoms, diagnostic methods, modern ML treatment are presented. Results of patients' examination in dynamics, disease course, prescribed therapy and response to it are described. The study substantiates the connection of PH development with hypoxemia and pulmonary hypoplasia, progression of multiple dysostosis, incl. facial dysmorphism and thoracic dysplasia in patients with ML. The algorithm for examining patients with ML should include monitoring of oxygen saturation and pressure in the pulmonary artery in order to timely diagnose and treat hypoxemia and PH. © 2019, Pediatria Ltd.. All rights reserved

The structure of interstitial lung diseases in children of the first two years of life

For the first time in Russia, the article provides data on interstitial lung diseases structure in children of the first two years of life, based on a series of observations of 68 patients with these rare diseases, as a part of multi-center ambispective study. Interstitial lung diseases in observed children included: Wilson-Mikity syndrome (23,4%), neuroendocrine hyperplasia of infancy (22%), bronchiolitis obliterans with organizing pneumonia (7,4%), primary pulmonary hypoplasia (1,5%), secondary pulmonary hypoplasia with Jeune syndrome (10,3%), secondary pulmonary hypoplasia with Edwards syndrome (2,9%), secondary pulmonary hypoplasia with other associated pathology (omphalocele - 1,5%, non-immune fetal hydrops - 1,5%), subpleural cysts in patients with Down syndrome (5,9%), congenital deficiency of surfactant protein B (1,5%), brain-lung- thyroid syndrome (2,9%), congenital alveolar-capillary dysplasia (1,5%), interstitial lung diseases with systemic diseases (Langerhans cell histiocytosis - 16,2%, Niemann-Pick disease - 1,5%). The article summarizes clinical features, the results of image diagnosis and disease outcomes. © 2015, Pediatria Ltd. All rights reserved

The structure of interstitial lung diseases in children of the first two years of life

For the first time in Russia, the article provides data on interstitial lung diseases structure in children of the first two years of life, based on a series of observations of 68 patients with these rare diseases, as a part of multi-center ambispective study. Interstitial lung diseases in observed children included: Wilson-Mikity syndrome (23,4%), neuroendocrine hyperplasia of infancy (22%), bronchiolitis obliterans with organizing pneumonia (7,4%), primary pulmonary hypoplasia (1,5%), secondary pulmonary hypoplasia with Jeune syndrome (10,3%), secondary pulmonary hypoplasia with Edwards syndrome (2,9%), secondary pulmonary hypoplasia with other associated pathology (omphalocele - 1,5%, non-immune fetal hydrops - 1,5%), subpleural cysts in patients with Down syndrome (5,9%), congenital deficiency of surfactant protein B (1,5%), brain-lung- thyroid syndrome (2,9%), congenital alveolar-capillary dysplasia (1,5%), interstitial lung diseases with systemic diseases (Langerhans cell histiocytosis - 16,2%, Niemann-Pick disease - 1,5%). The article summarizes clinical features, the results of image diagnosis and disease outcomes. © 2015, Pediatria Ltd. All rights reserved