313 research outputs found

    Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

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    Although most nephron segments contain one type of epithelial cell, the collecting ducts consists of at least two: intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. In adult kidneys, these cells are organized in rosettes suggesting functional interactions. Genetic studies in mouse revealed that transcription factor Tfcp2l1 coordinates IC and PC development. Tfcp2l1 induces the expression of IC specific genes, including specific H+-ATPase subunits and Jag1. Jag1 in turn, initiates Notch signaling in PCs but inhibits Notch signaling in ICs. Tfcp2l1 inactivation deletes ICs, whereas Jag1 inactivation results in the forfeiture of discrete IC and PC identities. Thus, Tfcp2l1 is a critical regulator of IC-PC patterning, acting cell-autonomously in ICs, and non-cell-autonomously in PCs. As a result, Tfcp2l1 regulates the diversification of cell types which is the central characteristic of 'salt and pepper' epithelia and distinguishes the collecting duct from all other nephron segments

    Effects Of Exposure To Sound On Discrimination Performance In The Rat.

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    PhDPsychologyUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/182242/2/0001117.pd

    Audiogenic Seizures and Sensitivity to Peripheral Shock

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    Novel Fabrication Approaches for Optoelectronic Halide Semiconductor Thin Films and Devices

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    Halide semiconductors have recently emerged as a class of materials that unite outstanding optoelectronic properties with the ability to process device-quality thin films at low or even room temperature. Successful adoption of halide semiconductor-based technologies will, however, be contingent on the development of device architectures and film processing approaches that enable efficient, low-cost devices with stable performance and rigorous study of these materials’ photophysical properties. Herein, the goals are twofold: first, to develop low-cost device processing methods that deliver efficient solar cell performance while managing sources of instability; second, to extend existing thin film processing techniques to novel materials, enabling investigation of their optoelectronic properties. After general introduction to halide perovskite materials, films and devices in Chapters 1 and 2, Chapter 3 confronts the first device challenge—i.e., reducing solar cell cost—by investigating cheap electron and hole transport layers (ETL and HTL) for halide perovskite solar cells. Efficient CH3NH3PbI3 perovskite solar cells are constructed using earth-abundant ETL CdS and HTL CuCrO2 that are deposited at low temperature (Chapter 4 focuses on the second device challenge—i.e., managing instability—by developing inherently robust architectures via lamination and hot pressing. This technique circumvents the intrinsic thermal instability of perovskite thin films during processing and forms a self-encapsulating device architecture. Annealing MAPbI3 films under pressure in a specially-constructed tool allows significant grain growth at temperatures that would ordinarily decompose them rapidly to PbI2. However, these temperatures can also activate unexpected reactions with carrier transport materials previously thought to be inert, such as nickel oxide. Applying this knowledge, techniques are developed that avoid reactivity-related problems and recover the targeted solar cell performance.Chapters 5 and 6 of this dissertation focus on developing deposition methods for new halide semiconductor films, with emphasis in this case on exploration of fundamental physical properties rather than device fabrication. In Chapter 5, resonant infrared matrix-assisted pulsed laser evaporation (RIR-MAPLE) is first used to deposit films of the archetypal halide perovskite CH3NH3PbI3, which possesses properties comparable to those prepared by more conventional methods such as spin coating, as determined by XRD, electron microscopy and optical spectroscopy. CH3NH3PbI3 solar cells fabricated using RIR-MAPLE reach power conversion efficiency of over 12%. RIR-MAPLE is then extended to the deposition of layered lead halide perovskite films incorporating oligothiophene-derived molecular cations, which cannot be controllably deposited by other methods. By varying the number of rings in the thiophene chain and the halide component of the inorganic layers, the photoluminescence emission from these films can be tuned to originate from either the inorganic or the organic component or be quenched altogether, supporting prior computational predictions of the tunable quantum well nature of these types of perovskite structures. Carrier transfer between the inorganic and organic moieties can synergistically populate triplet states in the organic, showcasing the unique physical properties attainable in complex-organic perovskites. Chapter 6 focuses on the halide semiconductor indium(I) iodide, which possesses elements of its electronic structure like those of halide perovskites, that are often invoked as an explanation for these materials’ remarkable defect tolerance. Indium(I) iodide is prepared in thin-film form by thermal evaporation. A photovoltaic effect is demonstrated for the first time in this material, with solar cells demonstrating ~0.4% power conversion efficiency. Overall, the results advance our scientific understanding of halide semiconductors, and provide crucial pathways by which they can be made more technologically effective, and be studied in greater depth.</p

    MINERAL METABOLISM IN RELATION TO ACID-BASE EQUILIBRIUM

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