Urban Forms and Future Cities: A Commentary

The commentary reflects on the critical ways in which the proliferation of private property rights and local planning powers constrain and delimit the changes in the forms of cities that will be required in the coming years to ensure that they remain productive, inclusive, and sustainable. It argues that the effective management of the coming disruptions now require a shift of power from the private and the local to the metropolitan and the regional

In defence of density

At their core, cities are absences of space between people. You can call it density, closeness, or proximity; it is the opposite of distance. The on-going COVID-19 pandemic has brought this core feature of cities under question. But this criticism paints with a broad brush: what matters are the type of density and the way it is managed

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Getting Results in Housing: A Framework for Monitoring Results in Housing Projects: Using Measurable Indicators

The aim of this paper is to help project teams develop results indicators for housing projects. These indicators are intended, primarily, as an instrument for managing projects and should help staff in the country offices, in headquarters and in executing agencies to identify the components of a project that are working as intended, and the ones that may need attention to keep the project on track. Additionally, the indicators can provide a foundation for project evaluations, at the mid-term or upon completion of the project

Lograr resultados en vivienda: Marco para hacer seguimiento a los resultados de proyectos de vivienda usando indicadores cuantitativos

Este documento identifica y define un conjunto de indicadores que cubren las áreas más importantes de intervenciones en los proyectos de vivienda. El objetivo principal es asistir a los equipos de proyectos y las contrapartes oficiales en la selección de indicadores adecuados para medir los insumos, productos, efectos e impactos de largo plazo. La División de Programas Sociales espera que esta publicación ayude a mejorar la calidad de los proyectos financiados por el Banco y la evaluación de su contribución al desarrollo del sector de vivienda, que es un sector social clave.

Why Pandemics, Such as COVID-19, Require a Metropolitan Response

We introduce evidence from the COVID-19 pandemic in the United States that lends support to future political efforts to include multi-county metropolitan areas as an additional and critical institutional layer&mdash;over and above municipalities, countries, states, or the federal government&mdash;for the effective management of present and future pandemics. Multi-county metropolitan statistical areas (MSAs) accommodated 73% of the U.S. population and, as of 27 September 2020, they were home to 78% of reported cases of COVID-19 and 82% of reported deaths. The rationale for a renewed focus on these spatial units is that they are found to be densely interconnected yet easily identifiable locales for the spread of pandemics and, therefore, for their proper management as well. The paper uses available data on cases and deaths in U.S. counties as of 27 September 2020 to lend statistical support to four hypotheses: (1) The Onset Hypothesis: The onset of COVID-19 cases and deaths commenced earlier in multi-county metropolitan areas than in small-city counties or rural counties; (2) The Peak Hypothesis: The current peak of COVID-19 cases and deaths occurred earlier in multi-county metropolitan areas; (3) The Scaling Hypothesis: Multi-county metropolitan areas had more than their shares of COVID-19 cases and deaths than their shares in the population; and (4) The Neighbor Hypothesis: Levels of COVID-19 cases and deaths in counties within multi-county metropolitan areas were more strongly related to respective levels in their neighboring counties than small-city counties or rural counties. The reported statistical results demonstrate the value of adopting a metropolitan perspective on pandemics and working to empower effective institutional arrangements at the metropolitan level for managing the present and future pandemics