15 research outputs found

    Consequences of chronic diseases and other limitations associated with old age - A scoping review

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    Funding Information: This work supported in part by the LTC INTER COST, Evaluation of the Potential for Reducing Health and Social Expenses for Elderly People Using the Smart Environment, through the Ministry of Education, Youth and Sports, Czech Republic, under Project LTC18035; and in part by the project of Excellence, University of Hradec Kralove, FIM, Czech Republic (ID: 2205–2019). First author – Petra Maresova is principle investigator of LTC18035 INTER COST project, from which Petra Maresova, Ondrej Krejcar and Kamil Kuca are funded for all expenses including personal costs. Ehsan Javanmardi is funded from project of Excellence ID: 2205–2019 for personal costs. Sabina Barakovic, Jasmina Barakovic Husic and Signe Tomsone are members of COST ACTION 16226 of which also Petra Maresova and Ondrej Krejcar are paticipants, while this article also ACKnowledge this project CA16226. Funding Information: The authors would like to hereby acknowledge COST Action CA16226 for their networking support. The Indoor Living Space Improvement: Smart Habitat for the Elderly played a role of networking platform for knowledge sharing and interchanging ideas for joint research and publication, what was the base for creating this study. Based on CA16226 project LTC18035 INTER COST was proposed for national funding support of COST ACTION Framework. COST is a funding agency that helps innovation and research networks. Our Action was instrumental in connecting research programmes throughout the EU region. Their contribution has made it possible for scientists to connect with each other and share their ideas and findings. This allows for more research and better innovation. More information can be found at www.cost.eu. The authors would also like to acknowledge the Excellence 2019 internal research project, Faculty of Informatics and Management, University of Hradec Kralove, Czech Republic. Publisher Copyright: © 2019 The Author(s).Background: The phenomenon of the increasing number of ageing people in the world is arguably the most significant economic, health and social challenge that we face today. Additionally, one of the major epidemiologic trends of current times is the increase in chronic and degenerative diseases. This paper tries to deliver a more up to date overview of chronic diseases and other limitations associated with old age and provide a more detailed outlook on the research that has gone into this field. Methods: First, challenges for seniors, including chronic diseases and other limitations associated with old age, are specified. Second, a review of seniors' needs and concerns is performed. Finally, solutions that can improve seniors' quality of life are discussed. Publications obtained from the following databases are used in this scoping review: Web of Science, PubMed, and Science Direct. Four independent reviewers screened the identified records and selected relevant publications published from 2010 to 2017. A total of 1916 publications were selected. In all, 52 papers were selected based on abstract content. For further processing, 21 full papers were screened." Results: The results indicate disabilities as a major problem associated with seniors' activities of daily living dependence. We founded seven categories of different conditions - psychological problems, difficulties in mobility, poor cognitive function, falls and incidents, wounds and injuries, undernutrition, and communication problems. In order to minimize ageing consequences, some areas require more attention, such as education and training; technological tools; government support and welfare systems; early diagnosis of undernutrition, cognitive impairment, and other diseases; communication solutions; mobility solutions; and social contributions. Conclusions: This scoping review supports the view on chronic diseases in old age as a complex issue. To prevent the consequences of chronic diseases and other limitations associated with old age related problems demands multicomponent interventions. Early recognition of problems leading to disability and activities of daily living (ADL) dependence should be one of essential components of such interventions.publishersversionPeer reviewe

    Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

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    Reprogrammed glucose metabolism as a result of increased glycolysis and glucose uptake is a hallmark of cancer. Here we show that cancer cells can suppress glucose uptake by non-tumour cells in the pre-metastatic niche, by secreting vesicles that carry high levels of the miR-122 microRNA. High miR-122 levels in the circulation have been associated with metastasis in breast cancer patients and we show that cancer-cell-secreted miR-122 facilitates metastasis by increasing nutrient availability in the pre-metastatic niche. Mechanistically cancer-cell-derived miR-122 suppresses glucose uptake by niche cells in vitro and in vivo by downregulating the glycolytic enzyme pyruvate kinase (PKM). In vivo inhibition of miR-122 restores glucose uptake in distant organs, including brain and lungs, and decreases the incidence of metastasis. These results demonstrate that by modifying glucose utilization by recipient pre-metastatic niche cells, cancer-derived extracellular miR-122 is able to reprogram systemic energy metabolism to facilitate disease progression

    Characteristics Analysis of the Pilot-Operated Proportional Directional Valve by Experimental and Numerical Investigation

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    The main valve spool structure of the pilot-operated proportional directional valve is diverse and has a direct impact on the flow field. To improve the valve’s performance, this work studied the characteristics of four types of spool structures with the following throttling groove arrangements: no throttling groove, a U-shaped groove, a triangle groove, and a combined groove. This study analyzed the flow field simulation of four spool structures under the same opening degree and different pressures to study the flow field cavitation characteristics and pressure distribution in the valve. According to the simulation results, the necessity of opening throttling grooves for the pilot proportional directional valve and the advantages of combined grooves over U-shaped and triangular grooves were verified. Then, the proportional valve with a combined groove structure was simulated and analyzed to study its throttling characteristics, steady flow characteristics, and flow and load differential pressure characteristics, and further explore the advantages of a combined groove. Finally, the experimental results are compared with the simulation results, which can provide a theoretical reference for the selection of the throttle groove of the proportional valve and the structural design of the slide valve

    Methods of Conserving and Managing Cultural Heritage in Classical Chinese Royal Gardens Based on 3D Digitalization

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    In this study, we aimed to implement information obtained and refined from garden elements in heritage conservation, monitoring, and management to precisely construct an information model of classical Chinese gardens, including information on the garden entity, garden space, and garden attributes, etc., and to improve the management efficiency of classical Chinese royal gardens. Three-dimensional laser scanning technology and point cloud information were used to accurately collect and process digital information from classical Chinese royal gardens. After classifying and processing the point cloud data, correlations therein could be further assessed and used to greatly improve the accuracy and management efficiency of spatial information. To provide a more convenient solution for the subsequent conservation and management of landscape heritage, a method for establishing a three-dimensional digital information database and a full life-cycle application management platform for classical Chinese royal gardens is proposed in this research. This method has broad applications for the digital conservation and management of cultural heritage

    Estimation of permeability and saturation based on imaginary component of complex resistivity spectra: A laboratory study

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    Low-frequency resistivity logging plays an important role in the field of petroleum exploration, but the complex resistivity spectrum of rock also contains a large amount of information about reservoir parameters. The complex resistivity spectra of 15 natural sandstone cores from western China, with different water saturations, were measured with an impedance analyzer. The pore space of each core was saturated with NaCl solution, and measurements were collected at a frequency range of 40–15 MHz. The results showed a linear relationship between the real resistivity at 1 kHz and the maximum values of imaginary resistivity for each core with different water saturations. The slopes of the linear best-fit lines had good linear relationships with the porosity and the permeability of cores. Based on this, a permeability estimation model was proposed and tested. In addition, the maxima of imaginary resistivity had power exponential relationships with the porosity and the water saturation of the cores. A saturation evaluation model based on the maxima of imaginary resistivity was established by imitating Archie’s formula. The new models were found to be feasible for determining the permeability and saturation of sandstone based on complex resistivity spectrum measurements. These models advance the application of complex resistivity spectrum in petrophysics

    Research on the Shale Porosity–TOC Maturity Relationship Based on an Improved Pore Space Characterization Method

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    Shale pore structure characterization is key to shale reservoir evaluation, sweet spot selection, and economic exploitation. It remains a challenge to accurately characterize shale micro-nano pores. Common experimental characterization methods for shale pore systems are listed, and advantages and weaknesses of each method are analyzed. An improved pore structure characterization method for shale is proposed by combining Helium and NMR. The new method does not affect shale samples and has a higher accuracy. The affecting factors for shale pore evolution for shale are also discussed, showing that organic matter content and maturity are key factors in total porosity development. Furthermore, a shale porosity–TOC maturity relationship chart is developed based on the experimental data of shale samples selected from six shale reservoirs. The application of this chart in Well X in the Gulong field of Songliao Basin proves its utility in evaluating shale reservoirs

    Polythionine and gold nanostar-based impedimetric aptasensor for label-free detection of α-synuclein oligomers

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    International audienceThe neurotoxicity of alpha-synuclein oligomers (alpha-syno) could cause Parkinson's disease (PD) which is an irreversible neurodegenerative disease. In order to diagnose and treat PD patients at an early stage and reduce the damage of sampling to humans, a non-invasive measure is used to analyze ultra-trace levels of alpha-syno. In this work, a new impedimetric aptasensor based polythionine (pTH)/Au nanostars (AuNSs) platform was designed for label-free detection of alpha-syno. The pTH and AuNSs demonstrated excellent electrical conductivity, fast electron transfer capability, and the synergistic amplification effect, which could enhance the sensitivity and improve the limit of detection (LOD). The ssDNA aptamers recognized and bound to alpha-syno via specific bases. Therefore, the ultra-sensitive alpha-syno aptasensor based on pTH and AuNSs presented a LOD of 0.07 aM and a dynamic range from 0.10 aM to 10.00 fM. The aptasensor also displayed good response range, high sensitivity, and low LOD in diluted human plasma samples to provide new methods for early diagnosis of PD

    Reverse Recovery Optimization of Multiepi Superjunction MOSFET Based on Tunable Doping Profile

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    This paper proposes and simulates research on the reverse recovery characteristics of two novel superjunction (SJ) MOSFETs by adjusting the doping profile. In the manufacturing process of the SJ MOSFET using multilayer epitaxial deposition (MED), the position and concentration of each Boron bubble can be adjusted by designing different doping profiles to adjust the resistance of the upper half P-pillar. A higher P-pillar resistance can slow down the sweep out speed of hole carriers when the body diode is turned off, thus resulting in a smoother reverse recovery current and reducing the current recovery rate (d (Formula presented.) /d (Formula presented.)) from a peak to zero. The simulation results show that the reverse recovery peak current (I (Formula presented.)) of the two proposed devices decreased by 5% and 3%, respectively, compared to the conventional SJ. Additionally, the softness factor (S) increased by 64% and 55%, respectively. Furthermore, this study also demonstrates a trade-off relationship between static and reverse recovery characteristics with the adjustable doping profile, thus providing a guideline for actual application scenarios.Electronic Components, Technology and MaterialsBio-Electronic
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