SaccadeNet: A Fast and Accurate Object Detector

Object detection is an essential step towards holistic scene understanding. Most existing object detection algorithms attend to certain object areas once and then predict the object locations. However, neuroscientists have revealed that humans do not look at the scene in fixed steadiness. Instead, human eyes move around, locating informative parts to understand the object location. This active perceiving movement process is called \textit{saccade}. %In this paper, Inspired by such mechanism, we propose a fast and accurate object detector called \textit{SaccadeNet}. It contains four main modules, the \cenam, the \coram, the \atm, and the \aggatt, which allows it to attend to different informative object keypoints, and predict object locations from coarse to fine. The \coram~is used only during training to extract more informative corner features which brings free-lunch performance boost. On the MS COCO dataset, we achieve the performance of 40.4\% mAP at 28 FPS and 30.5\% mAP at 118 FPS. Among all the real-time object detectors, %that can run faster than 25 FPS, our SaccadeNet achieves the best detection performance, which demonstrates the effectiveness of the proposed detection mechanism

Associations of the Triglyceride and Glucose Index With Hypertension Stages, Phenotypes, and Their Progressions Among Middle-Aged and Older Chinese

Objectives: To assess the associations of the triglyceride and glucose (TyG) index with hypertension stages, phenotypes, and their progressions.Methods: The data originated from the China Health and Retirement Longitudinal Study. Multinomial logistic regression investigated the associations of the TyG index with hypertension stages (stage 1, stage 2), phenotypes (isolated systolic hypertension [ISH], isolated diastolic hypertension [IDH], systolic diastolic hypertension [SDH]), their progressions.Results: Compared with the lowest quartile of TyG index, the highest quartile was associated with increased risks of stage 1 hypertension (OR 1.71, 95% CI 1.38–2.13), stage 2 (1.74, 1.27–2.38), ISH (1.66, 1.31–2.11), IDH (2.52, 1.26–5.05), and SDH (1.65, 1.23–2.23). Similar results were found when TyG index was a continuous variable. From 2011 to 2015, a higher baseline TyG index was associated with normotension to stage 1 (per-unit: 1.39, 1.16–1.65), normotension to ISH (per-unit: 1.28, 1.04–1.56), and normotension to IDH (per-unit: 1.94, 1.27–2.97).Conclusion: The TyG index was associated with different hypertension stages, phenotypes, their progressions, and could be served as a surrogate indicator for early hypertension management

Prognosis of HIV Patients Receiving Antiretroviral Therapy According to CD4 Counts: A Long-term Follow-up study in Yunnan, China

We aim to evaluate the overall survival and associated risk factors for HIV-infected Chinese patients on antiretroviral therapy (ART). 2517 patients receiving ART between 2006 and 2016 were prospectively enrolled in Yunnan province. Kaplan-Meier analyses and Cox proportional hazard regression analyses were performed. 216/2517 patients died during a median 17.5 (interquartile range [IQR] 6.8-33.2) months of follow-up. 82/216 occurred within 6 months of starting ART. Adjusted hazard ratios were10.69 (95%CI 2.38-48.02, p = 0.002) for old age, 1.94 (95%CI 1.40-2.69, p < 0.0001) for advanced WHO stage, and 0.42 (95%CI 0.27-0.63, p < 0.0001) for heterosexual transmission compared to injecting drug users. Surprisingly, adjusted hazard ratios comparing low CD4 counts group (<50 cells/μl) with high CD4 counts group (≥500 cells/μl) within six months after starting ART was 20.17 (95%CI 4.62-87.95, p < 0.0001) and it declined to 3.57 (95%CI 1.10-11.58, p = 0.034) afterwards. Age, WHO stage, transmission route are significantly independent risk factors for ART treated HIV patients. Importantly, baseline CD4 counts is strongly inversely associated with survival in the first six months; whereas it becomes a weak prognostic factor after six months of starting ART

Focus on vulnerable populations and promoting equity in health service utilization ––an analysis of visitor characteristics and service utilization of the Chinese community health service

Background Community health service in China is designed to provide a convenient and affordable primary health service for the city residents, and to promote health equity. Based on data from a large national study of 35 cities across China, we examined the characteristics of the patients and the utilization of community health institutions (CHIs), and assessed the role of community health service in promoting equity in health service utilization for community residents. Methods Multistage sampling method was applied to select 35 cities in China. Four CHIs were randomly chosen in every district of the 35 cities. A total of 88,482 visitors to the selected CHIs were investigated by using intercept survey method at the exit of the CHIs in 2008, 2009, 2010, and 2011. Descriptive analyses were used to analyze the main characteristics (gender, age, and income) of the CHI visitors, and the results were compared with that from the National Health Services Survey (NHSS, including CHIs and higher levels of hospitals). We also analyzed the service utilization and the satisfactions of the CHI visitors. Results The proportions of the children (2.4%) and the elderly (about 22.7%) were lower in our survey than those in NHSS (9.8% and 38.8% respectively). The proportion of the low-income group (26.4%) was apparently higher than that in NHSS (12.5%). The children group had the lowest satisfaction with the CHIs than other age groups. The satisfaction of the low-income visitors was slightly higher than that of the higher-income visitors. The utilization rate of public health services was low in CHIs. Conclusions The CHIs in China appears to fulfill the public health target of uptake by vulnerable populations, and may play an important role in promoting equity in health service utilization. However, services for children and the elderly should be strengthened

A correlation analysis of HHV infection and its predictive factors in an HIV-seropositive population in Yunnan, China

Human herpesviruses (HHVs) have a particularly high prevalence in certain high-risk populations and cause increased morbidity and mortality in patients with acquired immunodeficiency syndrome (AIDS). Screening and treating subclinical HHV infections reduce human immunodeficiency virus (HIV) infection incidence, disease progression, and transmission. However, there are few studies on HHVs, HIV coinfection rates, and their related risk factors. We aimed to clarify the prevalence of all eight HHVs in peripheral blood samples collected from HIV-positive patients, and explore the association of HHV infection in HIV-positive patients in an HIV-seropositive population in Yunnan. We recruited 121 HIV-positive patients with highly active antiretroviral therapy (HAART) and 45 healthy individuals. All the eight HHVs were detected using polymerase chain reaction and their epidemiological information and clinical data were collected and statistically analyzed. A high prevalence of HHVs (89.3%) was observed in individuals with HIV infections and with herpes simplex virus (HSV)-2 (65.3%), and HSV-1 (59.5%) being the most common. Coinfection with more than two different HHVs was more common in patients with HIV infections receiving HAART (72.7%) than in healthy controls. Older age, being married, higher HIV-1 plasma viral loads, and use of antiviral protease inhibitors were independently correlated with an increased frequency of HHVs, but we found no association with CD4 count, WHO HIV clinical stage, and HIV infection duration. Our findings are of great significance for the prevention of HHV opportunistic infection in patients with AIDS and their clinical treatment

Novel albumin-binding multifunctional probe for synergistic enhancement of FL/MR dual-modal imaging and photothermal therapy

The fluorescence/magnetic resonance (FL/MR) dual-modal imaging could provide accurate tumor visualization to guide photothermal therapy (PTT) of cancer, which has attracted widespread attention from scientists. However, facile and effective strategies to synergistically enhance fluorescence intensity, MR contrast and photothermal efficacy have rarely been reported. This study presents a novel multifunctional probe Gd-EB-ICG (GI) for FL/MR dual-modal imaging-guided PTT of cancer. GIs can self-assemble with endogenous albumin to form drug-albumin complexes (GIAs), which exhibit excellent biocompatibility. Albumin can protect GIAs from the recognition and clearance by the mononuclear phagocytic system (MPS). High plasma concentration and long half-life allow GIAs to accumulate continuously in the tumor area through EPR effect and specific uptake of tumor. Because of the prolonged rotational correlation time (τR) of Gd chelates, GIAs exhibited superior MR contrast performance over GIs with more than 3 times enhancement of longitudinal relaxation efficiency (r1). The fluorescence quantum yield and photothermal conversion efficiency of GIAs was also significantly improved due to the constrained geometry, disrupted aggregation and enhanced photothermal stability. This simple and feasible strategy successfully resulted in a synergistic effect for FL/MR dual-modal imaging and photothermal therapy, which can cast a new light for the clinical translation of multifunctional probes

Evaluation of Public Service Facilities in 19 Large Cities in China from the Perspective of Supply and Demand

The equalization of urban public service facilities is important to the daily lives of urban residents. Spatial quantification of the supply and demand of public service facilities can reveal relationships between supply and demand agents and provide a foundation for the planning of urban public service facilities. This study proposed a comprehensive framework to assess the current state of supply (accessibility of facilities) and demand (population carrying pressure) of various public services in cities and determine patterns between different public service facilities. This framework contains three elements: (a) multi-scale spatial quantification of the matching of supply and demand, (b) spatial matching of supply and demand, and (c) spatial clustering analysis of the supply and demand balance. This study analyzed 19 major cities in China from a supply and demand perspective and examined implications for matching the supply and demand of public service facilities. The results indicated that education service facilities had the most appropriate supply and demand relationship. Areas where public service facilities had a good matching of supply and demand demonstrated a strong pattern of clustering. There were significant differences in the level of matching of the supply and demand of public service facilities among various regions in China. The limitations of the framework and future directions are discussed

Evaluation of Public Service Facilities in 19 Large Cities in China from the Perspective of Supply and Demand

The equalization of urban public service facilities is important to the daily lives of urban residents. Spatial quantification of the supply and demand of public service facilities can reveal relationships between supply and demand agents and provide a foundation for the planning of urban public service facilities. This study proposed a comprehensive framework to assess the current state of supply (accessibility of facilities) and demand (population carrying pressure) of various public services in cities and determine patterns between different public service facilities. This framework contains three elements: (a) multi-scale spatial quantification of the matching of supply and demand, (b) spatial matching of supply and demand, and (c) spatial clustering analysis of the supply and demand balance. This study analyzed 19 major cities in China from a supply and demand perspective and examined implications for matching the supply and demand of public service facilities. The results indicated that education service facilities had the most appropriate supply and demand relationship. Areas where public service facilities had a good matching of supply and demand demonstrated a strong pattern of clustering. There were significant differences in the level of matching of the supply and demand of public service facilities among various regions in China. The limitations of the framework and future directions are discussed

Design of a potato stubble cutting machine for side delivery

In order to solve the problem that the traditional stubble cutting machine of potato is not complete, which the chopped stalks cannot be collected and utilized, a side delivering potato stubble cutting mechanism was designed in this paper. The characteristic is that the cutting, clamping and delivering of potato plant stalks completed by the cooperation of the reel and the triangle-clamping chain, and the strip is laid on the right side of the machine. The machine can manually adjust the height of the cutting table, easy to operate, installed in the front of the tractor