The Effect of Foundation Shape on Dynamic Parameter of Bases

It has been proved that the shape of foundation and its base side ratio affect the dynamic rigidity of sliding-rotation vibration of bases. Based on plenty of laboratory tests in a small sides the computing formulas of rigidity and damping of base considering the effect of base side ratio are put forward

On Propagation of Elastic Surface Wave in Soils

It has been proved that the propagation law of elastic surface wave emanating from machinery foundations has bearing not only on distances from vibration source but also on frequencies and depth of vibration source and external pressure acting on soil surface of wave receivers. Based on plenty of tests the calculation formulas for elastic surface wave are put forward and the computation precision of which is satisfactory

Direct numerical simulation of compressible turbulence accelerated by graphics processing unit. Part 1: An open-source high accuracy accelerated computational fluid dynamic software

This paper introduces open-source computational fluid dynamics software named open computational fluid dynamic code for scientific computation with graphics processing unit (GPU) system (OpenCFD-SCU), developed by the authors for direct numerical simulation (DNS) of compressible wall-bounded turbulence. This software is based on the finite difference method and is accelerated by the use of a GPU, which provides an acceleration by a factor of more than 200 compared with central processing unit (CPU) software based on the same algorithm and number of message passing interface (MPI) processes, and the running speed of OpenCFD-SCU with just 512 GPUs exceed that of CPU software with 130\,000 CPUs. GPU-Stream technology is used to implement overlap of computing and communication, achieving 98.7\% parallel weak scalability with 24\,576 GPUs. The software includes a variety of high-precision finite difference schemes, and supports a hybrid finite difference scheme, enabling it to provide both robustness and high precision when simulating complex supersonic and hypersonic flows. When used with the wide range of supercomputers currently available, the software should able to improve the performance of large-scale simulations by up to two orders on the computational scale. Then, OpenCFD-SCU is applied to a validation and verification case of a Mach 2.9 compression ramp with mesh numbers up to 31.2 billion. More challenging cases using hybrid finite schemes are shown in Part 2(Dang, Li et al. 2022). The code is available and supported at \url{http://developer.hpccube.com/codes/danggl/opencfd-scu.git}.Comment: 23 pages, 25 figure

The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases

The telomere is located at the end of the chromosome and consists of a non-coding, repetitive DNA sequence. As the cell divides, the length of telomere gradually decreases. A very short telomere can terminate mitosis, and thus telomere length becomes a hallmark of cellular aging. The 500 kb region of each autosomal arm terminal is the so-called subtelomeric region. Both telomere and subtelomere have high-density DNA repeats. Telomeres do not contain genes or CpG sequences, while subtelomeres contain small amounts of genes and high-density CpG sequences, and DNA methylation often occurs in subtelomeres. Previous studies have shown that aberrant methylation of subtelomeric DNA exists in many diseases, and it has a certain effect on the regulation of telomere length. In this review, we focus on the correlation between subtelomeric DNA methylation and aging-related diseases. We also summarize the relationship between subtelomeric methylation and telomere length in different diseases

Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS

Although genome-wide association studies (GWAS) of complex traits have yielded more reproducible associations than had been discovered using any other approach, the loci characterized to date do not account for much of the heritability to such traits and, in general, have not led to improved understanding of the biology underlying complex phenotypes. Using a web site we developed to serve results of expression quantitative trait locus (eQTL) studies in lymphoblastoid cell lines from HapMap samples (http://www.scandb.org), we show that single nucleotide polymorphisms (SNPs) associated with complex traits (from http://www.genome.gov/gwastudies/) are significantly more likely to be eQTLs than minor-allele-frequency–matched SNPs chosen from high-throughput GWAS platforms. These findings are robust across a range of thresholds for establishing eQTLs (p-values from 10−4–10−8), and a broad spectrum of human complex traits. Analyses of GWAS data from the Wellcome Trust studies confirm that annotating SNPs with a score reflecting the strength of the evidence that the SNP is an eQTL can improve the ability to discover true associations and clarify the nature of the mechanism driving the associations. Our results showing that trait-associated SNPs are more likely to be eQTLs and that application of this information can enhance discovery of trait-associated SNPs for complex phenotypes raise the possibility that we can utilize this information both to increase the heritability explained by identifiable genetic factors and to gain a better understanding of the biology underlying complex traits.</p