The Ursinus Weekly, October 16, 1933

Freshmen hold traditional banquet at Bungalow Inn • Women consider campus problems at mass meeting • Dickinson holds grizzlies to a 7-7 tie in opening conference game • Freshman gridders down Perkiomen Prep, 12-0 • Citizens hear address on national disarmament • Old timers and undergrads enjoy dance in gymnasium • Dickinson to observe 150th anniversary this week • Varsity hockey players defeat Beaver by 3-4 score • Soccer team subdues Girard College by a 5-2 score • Men debaters to hold initial meeting tonight • Former instructor accepts position at own alma mater • Cornelia Otis Skinner to appear at Norris Theatre • Alumnae hockey stars lose to varsity eleven • Trees theme of well- attended vesper services • Artist-students\u27 concert to open culture course • Sister classes hold traditional get-together • Modern language group may organize French Club • Club discusses Pilsudski, Gomez, Feisal, and Azana • Laboratory technician addresses women students • Well-known physician to address women students • Advisor lectures on new plays before literary club • YW party postponed • Prayer discussed by Brotherhood of St. Paul • Glee Club preparing to appear in nearby towns • Dr. Homer Smith to address meeting of English group • Y.M. symposium planned • Essig injured in collision • Advisees are entertained • Ruby photographers to receive proofs this weekhttps://digitalcommons.ursinus.edu/weekly/2001/thumbnail.jp

The Ursinus Weekly, March 12, 1934

Dr. Schelling honored on Founders\u27 Day • Cheating problem is chosen for study • Varsity courtmen close season with 45-33 victory over Lebanon Valley • Seniors promise gay week-end activities • Lawson Robertson to speak at Varsity Club banquet • Women debaters hold dual meet with Temple • Frosh down Perkiomen but lose to Wyoming Seminary • Swarthmore co-ed varsity bows to Ursinus basketeers • Philadelphia artists give recital Thursday night • Winter meeting of Board of Directors held Founders\u27 Day • Men forensic artists meet Wagner and Gettysburg • Day students down Derr to lead inter-dorm league • Cancer specialist will be chapel speaker in April • Sorority conducts vespers • Women students hear horticulture lecture • College to be scene of Asbury summer school • Local AAUW branch is under consideration • Heiges high scorer in inter-dormitory league • Lansdale Kiwanis Club hears Ursinus professor • Vertebrate anatomists visit medical schools • Community club holds annual husband\u27s night • Bacteriologist will speak to pre-medical society • Day cagers defeat Maples • YW program presented by Royersford Tri-Hi-Y • Brotherhood of St. Paul conducts two meetings • Club will discuss essay • Modern language group hears Dr. Calvin D. Yost • Phi Alpha Psi reunionhttps://digitalcommons.ursinus.edu/weekly/2016/thumbnail.jp

The Ursinus Weekly, November 20, 1933

Hilarious comedy staged by dormitory committee • Men hold traditional football season smoker • Bears win fourth straight victory over Swarthmore by 13-0 score • I.N.A. convention meets at Johns Hopkins • Frosh end 1933 grid season undefeated • Pep rally dedicated to senior gridiron warriors • Main Line defeats hockey team in spirited encounter • Cast chosen for Curtain Club offering Firebrand • Woman\u27s Club entertains freshman girls at tea • Season\u27s last soccer game ends in deadlock • Woman\u27s dormitory committee sponsors bazaar and tea • I.R.C. gives armistice program at open meeting • Glee Club to give concert • Treasurers to meet Wed. • French Club to hold initial meeting Tuesday • College is host to Carmel Quarterly Club • Beta Sigma holds dance • New plan adopted for instrumental ensembles • Women students to hear pres. of medical college • William Mitchell succumbs • Y.W.C.A. considers condition of the negro • Y.M. hears prof. Boswell • Forensic Club picks questions for debating season • Modern novel is subject for English Club discussion • Litvinoff and Roosevelt appear at Debating Club • College host to reformed church workers\u27 meeting • College is given trees • Sorority pledges • Brodbeck leading in inter-dormitory football conference • History-soc. science group to hear James T. Young • College department of Sunday School gives novel party • Dance and membership pins planned by Varsity Clubhttps://digitalcommons.ursinus.edu/weekly/2006/thumbnail.jp

The Ursinus Weekly, February 5, 1934

Felix Schelling to give address • Illustrated lecture to be presented • Ursinus cagers lose to LVC • Swedemen lose to Wyoming Sem. • Guest to lecture on electrotypes • Naturalist to speak on Friday, May 11 • Ursinus treasurer cited for assistance to scouting • Leroy Wilson plays for annual sophomore hop • Dr. Victor Monod to speak in April • Men\u27s debating teams to hold practice encounter Wednesday • Grizzly matmen bow to Lafayette, 30 to 8 • Questionnaire prepared to ascertain student opinion • Y.M. and Y.W. secure John R. Hart for prayer week • Women debaters plan several encounters on two questions • Dr. Omwake re-elected by college presidents\u27 ass\u27n • Dr. Philip Goepp to present students in annual recital • Ruby questionnaire to be distributed among seniors • Brotherhood of St. Paul to conduct Sunday services • Y.W. holds novel meeting • Nurses give minstrel show • Grizzly cagers trounced by Villanova wildcats • Grizzly cubs defeat frosh cagers at Villanova, 30-28 • Phoenix Independents hold U basketeers to 28-28 tie • Dean of women represents college at conferences • Hall Chemical Society hears Dr. Russell Sturgis • Curtain Club chooses plays • Stories discussed by club • Best pageants written by misses Brooks and Meyer • Intra-mural sports for winter season scheduledhttps://digitalcommons.ursinus.edu/weekly/2011/thumbnail.jp

The Ursinus Weekly, June 5, 1933

New science building dedicated at sixty-third annual commencement • Dr. Paul Gerhard speaks at baccalaureate service • Beethoven\u27s Mass in D is commencement oratorio • Court trials featured at class day exercises • Johnsonmen down Drexel in final game of season • Ursinus Woman\u27s Club holds business meeting • Business luncheon held by alumni athletic club • Prizes awarded at annual commencement • Board of Directors holds annual session at college • Four appointments made to the teaching staff • Four honorary degrees awarded at commencement • Alumni association elects officers for the coming year • Open scholarship awards announced by committee • Annual alumni banquet held last Saturday evening • Faculty holds picnic in Trinity Reformed Church • Dr. Yost addresses seniors • Woman\u27s Club entertains senior girls at bridge tea • Club discusses Van Dyke • Tropp to head track team • Modern language officers • President and Mrs. Omwake hosts at senior reception • Received degrees today • Girls\u27 basketball squad holds annual banquet • Students present recital • English Club luncheon • James M. Anders addresses Schwenkfeldian meeting • Hall presidents initiated • Organ recital at vespers • Criticism of 1933 Ruby made by prof. Sheeder • Tau Kappa Alpha initiates and elects new officers • Ursinus Woman\u27s Club host to senior girls • Dr. and Mrs. Gerhard guests at Superhouse reception • Phi Alpha Psi entertains seniors at Freeland Househttps://digitalcommons.ursinus.edu/weekly/2058/thumbnail.jp

The Lantern Vol. 3, No. 2, March 1935

• Puppets of Propaganda • Reluctance • Reflections From My Diary • Reverie • Bash Turner Enters the Limelight • The College Students\u27 Obligation • The Schwenkfelders • Love\u27s Desire • Verse • On the Squirt of a Grapefruit • Pioneers! • Whither Fraternities? • Mary Peters: A Book Review • Different as Night and Day • Ode to an Alley Cathttps://digitalcommons.ursinus.edu/lantern/1005/thumbnail.jp

Mutations in PIEZO2 Cause Gordon Syndrome, Marden-Walker Syndrome, and Distal Arthrogryposis Type 5

Gordon syndrome (GS), or distal arthrogryposis type 3, is a rare, autosomal-dominant disorder characterized by cleft palate and congenital contractures of the hands and feet. Exome sequencing of five GS-affected families identified mutations in piezo-type mechanosensitive ion channel component 2 (PIEZO2) in each family. Sanger sequencing revealed PIEZO2 mutations in five of seven additional families studied (for a total of 10/12 [83%] individuals), and nine families had an identical c.8057G>A (p.Arg2686His) mutation. The phenotype of GS overlaps with distal arthrogryposis type 5 (DA5) and Marden-Walker syndrome (MWS). Using molecular inversion probes for targeted sequencing to screen PIEZO2, we found mutations in 24/29 (82%) DA5-affected families and one of two MWS-affected families. The presence of cleft palate was significantly associated with c.8057G>A (Fisher’s exact test, adjusted p value < 0.0001). Collectively, although GS, DA5, and MWS have traditionally been considered separate disorders, our findings indicate that they are etiologically related and perhaps represent variable expressivity of the same condition

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Whole-genome analysis reveals that mutations in inositol polyphosphate phosphatase-like 1 cause opsismodysplasia.

Opsismodysplasia is a rare, autosomal-recessive skeletal dysplasia characterized by short stature, characteristic facial features, and in some cases severe renal phosphate wasting. We used linkage analysis and whole-genome sequencing of a consanguineous trio to discover that mutations in inositol polyphosphate phosphatase-like 1 (INPPL1) cause opsismodysplasia with or without renal phosphate wasting. Evaluation of 12 families with opsismodysplasia revealed that INPPL1 mutations explain ~60% of cases overall, including both of the families in our cohort with more than one affected child and 50% of the simplex cases

Whole-genome analysis reveals that mutations in inositol polyphosphate phosphatase-like 1 cause opsismodysplasia.

Opsismodysplasia is a rare, autosomal-recessive skeletal dysplasia characterized by short stature, characteristic facial features, and in some cases severe renal phosphate wasting. We used linkage analysis and whole-genome sequencing of a consanguineous trio to discover that mutations in inositol polyphosphate phosphatase-like 1 (INPPL1) cause opsismodysplasia with or without renal phosphate wasting. Evaluation of 12 families with opsismodysplasia revealed that INPPL1 mutations explain ~60% of cases overall, including both of the families in our cohort with more than one affected child and 50% of the simplex cases