Myelolipoma of the Pelvis: A Case Report and Review of Literature

Myelolipomas are uncommon, benign tumors which typically occur in the adrenal glands and consist of mature adipose tissue and benign hematopoietic components. Myelolipomas can occur outside of the adrenal glands, but the presacral region, retroperitoneum, pelvis, and mediastinum are unusual locations for these tumors. It is important to recognize this entity in these locations since they can attain massive sizes leading to pressure symptoms and need to be differentiated from the malignant tumors like liposarcomas. We present a myelolipoma case in the presacral region. Our case illustrates the clinical approach of these tumors in such unusual locations

CMB-S4

We describe the stage 4 cosmic microwave background ground-based experiment CMB-S4

Coal Mine Safety Monitoring and Alerting System with Smart Helmet

Traditional monitoring systems in coal mines are difficult to install, hazardous, and difficult to power. Because of the complexity of the mining environment and the wide range of operations performed in coal mines, it is vital to monitor and maintain the parameters in the background t increase the efficiency and safety of mineworkers. As a result, traditional monitoring methods cannot be relied on to ensure coal workers’ safety. This research represents a ZigBee-based wireless monitoring system using a smart helmet. The presented wireless monitoring system is capable of detecting and transmitting critical parameters in coal mines such as methane gas, high temperature, humidity, and fire. In an emergency, this monitoring system transmits distress signals. A buzzer will sound if emergency conditions are detected, and the monitored variables will be displayed on the user interface machine. Moreover, the Parameters are wirelessly transmitted to the control room, allowing people to determine the safety situation of the mine. This model is easily reprogrammable. Experiments have demonstrated the system’s reliability and stability

A study to evaluate host factors for musculoskeletal injuries secondary to trauma among elderly people of Northwestern India

Introduction: As the population ages, the problems related to falls and fractures are expected to grow. This poses a great challenge to the health-care systems. Meeting these challenges requires a clear understanding of the prevalence and nature of falls. It also means identifying factors responsible for injury causation. The current study was conducted with the aim to evaluate host factors responsible for musculoskeletal injuries (MSIs) in the elderly. Materials and Methods: A hospital-based, questionnaire-based, descriptive study was conducted on all elderly (60 years) patients attending a tertiary care teaching hospital with MSIs secondary to trauma between 2013 and 2014. Results: A total of 200 elderly with MSIs secondary to trauma attending the tertiary care center between 2013 and 2014 were evaluated for the purpose of this study. Exactly half of them (50%) were more than 70 years of age. Intoxication and presence of visual and hearing impairment were observed as significantly associated with occurrence of MSIs. Discussion: Trauma is a common cause of MSI among the elderly. Therefore, identification and evaluation of host factors are important as this can help in planning prevention of injuries in elderly. Conclusion: MSIs due to trauma are a focus of public health practice as they pose a serious health threat, occur frequently, and are in most situations preventable

Modulation of the immune response and infection pattern to Leishmania donovani in visceral leishmaniasis due to arsenic exposure: An in vitro study.

The arsenic contamination of ground water in visceral leishmaniasis (VL) endemic areas in Bihar, India leads to human exposure through drinking water. Possibly, the consumed arsenic (As) accumulates in the tissues of VL patients, who subsequently internalize intracellular amastigotes to confer resistance against chemotherapy to the parasite, leading to modulation in the host's immune response. This hypothesis appears to be consistent with the in vitro findings that in arsenic-exposed parasites, the mitochondrial membrane potential became depolarized, whereas the reduced thiol and lactate production was overexpressed with enhanced glucose consumption; therefore, the reduced thiol possibly supports an immunosuppressive state in the host cells. This observation was well supported by the down-regulated expression of pro-inflammatory cytokines (IL-2, IL-12, IFN-γ, and TNF-α) with a suppressed anti-leishmanial function of macrophage (NO, ROS). In contrast, the pathophysiological mechanism of VL has received ample support by the promotion of Th2 cytokines (IL-4 and IL-10) in the presence of arsenic-exposed Leishmania parasites (LdAS). Dysfunction of mitochondria and the overexpression of lactate production raise the possibility of the Warburg effect being operative through the up-regulation of glucose consumption by parasites to enhance the energy production, possibly augmenting virulence. Therefore, we surmise from our data that arsenic exposure to Leishmania donovani modulates the immune response and infection pattern by impairing parasite function, which may affect the anti-leishmanial effect in VL

Human Behavior-Inspired Linchpin-Directed Catalysis for Traceless Precision Labeling of Lysine in Native Proteins

The complex social ecosystem regulates the spectrum of human behavior. However, it becomes relatively easier to understand if we disintegrate the contributing factors, such as locality and interacting partners. Interestingly, it draws remarkable similarity with the behavior of a residue placed in a social setup of functional groups in a protein. Can it inspire principles for creating a unique environment for the precision engineering of proteins? We demonstrate that localization-regulated interacting partner(s) could render precise and traceless single-site modification of structurally diverse native proteins. The method targets a combination of high-frequency Lys residues through an array of reversible and irreversible reactions. However, excellent simultaneous control over chemoselectivity, site selectivity, and modularity ensures that the user-friendly protocol renders acyl group installation, including post-translational modifications (PTMs), on a single Lys. Besides, it offers a chemically orthogonal handle for the installation of probes. Also, a purification protocol integration delivers analytically pure single-site tagged protein bioconjugates. The precise labeling of a surface Lys residue ensures that the structure and enzymatic activities remain conserved post-bioconjugation. For example, the precise modification of insulin does not affect its uptake and downstream signaling pathway. Further, the method enables the synthesis of homogeneous antibody–fluorophore and antibody–drug conjugates (AFC and ADC; K183 and K249 labeling). The trastuzumab–rhodamine B conjugate displays excellent serum stability along with antigen-specific cellular imaging. Further, the trastuzumab–emtansine conjugate offers highly specific antiproliferative activity toward HER-2 positive SKBR-3 breast cancer cells. This work validates that disintegrate theory can create a comprehensive platform to enrich the chemical toolbox to meet the technological demands at the chemistry, biology, and medicine interface