Musca cadaverina

Cruciform compound, 2,6-bis­(phenylethynyl)-4,8-bis­(phenylethynyl)­benzo­[1,2-<i>b</i>:4,5-<i>b</i>′]­dithiophene and its alkyl substituted derivatives, <b>1a</b>–<b>d</b>, were designed and synthesized. Their physicochemical properties were studied by thermogravimetric analysis, absorption spectra, and cyclic voltammetry. Single crystal diffraction results revealed that <b>1a</b>–<b>d</b> adopted different molecular packing in the solid state, which was caused by the introduction and the different orientations of alkyl chains. The single micrometer ribbon transistors of <b>1a</b> displayed high mobility up to 0.81 cm² V^–1 s^–1. And the as-spun thin film transistors of <b>1c</b> exhibited mobility as high as 0.106 cm² V^–1 s^–1, 2 orders of magnitude higher than those of <b>1b</b> (0.006 cm² V^–1 s^–1) and <b>1d</b> (0.002 cm² V^–1 s^–1)

Benzo[1,2‑<i>b</i>:4,5‑<i>b</i>′]dithiophene-Based Cruciforms: Syntheses, Crystal Structures, and Charge Transport Properties

Cruciform compound, 2,6-bis­(phenylethynyl)-4,8-bis­(phenylethynyl)­benzo­[1,2-<i>b</i>:4,5-<i>b</i>′]­dithiophene and its alkyl substituted derivatives, <b>1a</b>–<b>d</b>, were designed and synthesized. Their physicochemical properties were studied by thermogravimetric analysis, absorption spectra, and cyclic voltammetry. Single crystal diffraction results revealed that <b>1a</b>–<b>d</b> adopted different molecular packing in the solid state, which was caused by the introduction and the different orientations of alkyl chains. The single micrometer ribbon transistors of <b>1a</b> displayed high mobility up to 0.81 cm² V^–1 s^–1. And the as-spun thin film transistors of <b>1c</b> exhibited mobility as high as 0.106 cm² V^–1 s^–1, 2 orders of magnitude higher than those of <b>1b</b> (0.006 cm² V^–1 s^–1) and <b>1d</b> (0.002 cm² V^–1 s^–1)

Electron-Rich Pyrroloindacenodithiophenes: Synthesis, Characterization, and Spectroscopic Studies

<i>N</i>-Alkyl substituted pyrroloindacenodithiophene (PIDT) and their phenyl substituted derivatives were synthesized. Their single-crystal structures and electrochemical and spectroscopic properties were investigated. Experimental results showed PIDT displayed strong electron-donating properties, reversible redox behaviors, and strong fluorescence and could be controlled to oxidize to radical cation and dication with distinctive optical changes. These attractive properties demonstrated the potential applications of PIDT in the field of switches, molecular machines, and information memories

Electron-Rich Pyrroloindacenodithiophenes: Synthesis, Characterization, and Spectroscopic Studies

<i>N</i>-Alkyl substituted pyrroloindacenodithiophene (PIDT) and their phenyl substituted derivatives were synthesized. Their single-crystal structures and electrochemical and spectroscopic properties were investigated. Experimental results showed PIDT displayed strong electron-donating properties, reversible redox behaviors, and strong fluorescence and could be controlled to oxidize to radical cation and dication with distinctive optical changes. These attractive properties demonstrated the potential applications of PIDT in the field of switches, molecular machines, and information memories

Data_Sheet_1_A novel BCL11A polymorphism influences gene expression, therapeutic response and epilepsy risk: A multicenter study.doc

BackgroundGenetic factors have been found to be associated with the efficacy and adverse reactions of antiseizure medications. BCL11A is an important regulator of the development of neuronal networks. However, the role of BCL11A in epilepsy remains unclear. This study aimed to evaluate the genetic association of BCL11A with the susceptibility to develop epileptic seizures and therapeutic response of patients with epilepsy in Han Chinese.MethodsWe matched 450 epilepsy cases with 550 healthy controls and 131 drug-resistant epilepsy patients with 319 drug-responsive epilepsy patients from two different centers. Genetic association analysis, genetic interaction analysis, expression quantitative trait loci analysis and protein–protein interaction analysis were conducted.ResultsOur results showed that rs2556375 not only increases susceptibility to develop epileptic seizures (OR = 2.700, 95% = 1.366–5.338, p = 0.004 and OR = 2.984, 95% = 1.401–6.356, p = 0.005, respectively), but also increases the risk of drug resistance(OR = 21.336, 95%CI =2.489–183.402, p = 0.005). The interaction between rs2556375 and rs12477097 results in increased risk for pharma coresistant. In addition, rs2556375 regulated BCL11A expression in human brain tissues (p = 0.0096 and p = 0.033, respectively). Furthermore, the protein encoded by BCL11A interacted with targets of approved antiepileptic drugs.ConclusionBCL11A may be a potential therapeutic target for epilepsy. Rs2556375 may increase the risks of epilepsy and drug resistance by regulating BCL11A expression in human brain tissues. Moreover, the interaction between rs2556375 and rs12477097 results in increased risk for drug resistance.</p

Additional file 1 of Identification of potential crucial genes and therapeutic targets for epilepsy

Additional file 1: Table S1. 91 DEGs were identified in GSE44031 series