Enantioselective synthesis of polyhydroxyindolizidinone and quinolizidinone derivatives from a common precursor

A concise asymmetric synthetic route to two new tetrahydroxyindolizidinone and quinolizidinone derivatives has been developed from a common intermediate which featured a highly selective dihydroxylation reaction and a RCM reaction as key steps

Unified Approach to the Asymmetric Synthesis of Higher Homologues of (3-Quinolyl)-alanine

<div><p></p><p>A new protocol based on a palladium-catalyzed Heck reaction of an amino acid–derived vinyl unit with 3-bromoquinoline has been developed to access the title compounds in good yield and optical purity.</p> </div

Grob-type fragmentation of a carvone derived β-hydroxymesylate: application to the synthesis of chiral lavandulol derivatives

Grob-type fragmentation of the carvone derived diol-monosulphonate 5 has been utilised for the enantioselective synthesis of various lavandulol derivatives

A unified approach to the important protein kinase inhibitor balanol and a proposed analogue

A common approach to the important protein kinase inhibitor (−)-balanol and an azepine-ring-modified balanol derivative has been developed using an efficient fragment coupling protocol which proceeded in good overall yield

Grob-type fragmentation of a carvone derived beta-hydroxymesylate: application to the synthesis of chiral lavandulol derivatives

Grob-type fragmentation of the carvone derived diol-monosulphonate 5 has been utilised for the enantioselective synthesis of various lavandulol derivative

Enantiodivergency and Enantioconvergency in the Synthesis of the Dendrobate Alkaloid 241D

A diastereodivergent preparation of two <i>N</i>-alkenylnitrones (<b>9</b> and <b>11</b>) from easily available (<i>R</i>)-2,3-<i>O</i>-cyclohexylideneglyceraldehyde (<b>5</b>) led to an enantiodivergent synthesis of both enantiomers of the dendrobate alkaloid 241D in a sequential two-directional approach involving intramolecular nitrone cycloaddition as the key step. Either of these two nitrones could, in principle, be utilized for the preparation of the title compounds in an enantioconvergent fashion as well. The methodology was extended to prepare an analogue (<b>33</b>) of (−)-241D

A new carvone based construction of the ring-A of taxoids

A synthesis of the fully functionalized A-ring of taxoids from the commercially available monoterpenic chiron R-carvone is outlined. In this approach, regio- and stereoselective restructuring of alkyl substituents and functionalities is effected on the periphery while retaining the six membered core of carvone

A New Carvone Based Construction of the Ring-A of Taxoids

A synthesis of the fully functionalized A-ring of taxoids from the commercially available monoterpenic chiron R-carvone is outlined. In this approach, regio- and stereoselective restructuring of alkyl substituents and functionalities is effected on the periphery while retaining the six membered core of carvone

δ,ε-Unsaturated α,β-Diamino Acids as Building Blocks for the Asymmetric Synthesis of Diverse α,β-Diamino Acids

A building block approach for the synthesis of α,β-diamino acids is described, which involves the diastereodivergent preparation of two sets of orthogonally protected δ,ε-unsaturated α,β-diamino acids as templates for the preparation of 12 new α,β-diamino acids of biological relevance using simple techniques