HIV associated cell death: Peptide-induced apoptosis restricts viral transmission.

The human immunodeficiency virus (HIV) is still a global pandemic and despite the successful use of anti-retroviral therapy, a well-established cure remains to be identified. Viral modulation of cell death has a significant role in HIV pathogenesis. Here we sought to understand the major mechanisms of HIV- induced death of lymphocytes and the effects on viral transmission. Flow cytometry analysis of lymphocytes from five latent HIV-infected patients, and HIV IIIB-infected MT2 cells demonstrated both necrosis and apoptosis to be the major mechanisms of cell death in CD4+ and CD4-/CD8- lymphocytes. Significantly, pro-apoptotic tumor necrosis factor (TNF) peptide (P13) was found to inhibit HIV-related cell death and reduced viral transmission. Whereas pro-necrotic TNF peptide (P16) had little effect on HIV-related cell death and viral transmission. Understanding mechanisms by which cell death can be manipulated may provide additional drug targets to reduce the loss of CD4+ cells and the formation of a viral reservoir in HIV infection

The NIM Inertial Mass Measurement Project

An inertial mass measurement project, which is expected to precisely measure the Planck constant, $h$, for possible comparisons with known gravitational mass measurement projects, e.g., the watt balance and the Avogadro project, is being carried out at the National Institute of Metrology, China. The principle, apparatus, and experimental investigations of the inertial mass measurement are presented. The prototype of the experiment and the Planck constant with relative uncertainty of several parts in $10^{4}$ have been achieved for principle testing.Comment: 9pages, 12 figures, accepted for publication in IEEE Transactions on Instrumentation and Measuremen

Can Large Language Models Understand Real-World Complex Instructions?

Large language models (LLMs) can understand human instructions, showing their potential for pragmatic applications beyond traditional NLP tasks. However, they still struggle with complex instructions, which can be either complex task descriptions that require multiple tasks and constraints, or complex input that contains long context, noise, heterogeneous information and multi-turn format. Due to these features, LLMs often ignore semantic constraints from task descriptions, generate incorrect formats, violate length or sample count constraints, and be unfaithful to the input text. Existing benchmarks are insufficient to assess LLMs' ability to understand complex instructions, as they are close-ended and simple. To bridge this gap, we propose CELLO, a benchmark for evaluating LLMs' ability to follow complex instructions systematically. We design eight features for complex instructions and construct a comprehensive evaluation dataset from real-world scenarios. We also establish four criteria and develop corresponding metrics, as current ones are inadequate, biased or too strict and coarse-grained. We compare the performance of representative Chinese-oriented and English-oriented models in following complex instructions through extensive experiments. Resources of CELLO are publicly available at https://github.com/Abbey4799/CELLO

Studying the influence of cold-core mesoscale ocean eddies on sound propagation based on the parabolic equation method

Mesoscale vorticity is an important factor that affects the non-uniform horizontal and vertical distribution of hydrologic elements in the ocean. In this paper, temperature and salinity data from measured mesoscale cold-core eddies during a voyage within a certain sea area are studied, and a synchronous sound field test was conducted on the mesoscale vorticity. Based on the temperature and salinity data, the parabolic equation (PE) method was selected to predict the acoustic field, and the results were compared with the measured propagation loss data of the acoustic field to verify the accuracy and effectiveness of the PE model. The underwater sound propagation characteristics in the mesoscale cold-core eddy environment were then analyzed using the temperature and salinity data retrieved from the voyage. It was found that the convergence area of the acoustic field gradually dispersed with an increase in the depth of the sound source. In a mesoscale eddy environment, when sound waves propagate from inside to outside the eddy, the presence of a cold-core eddy causes the convergence area to shift toward the edge of the eddy, and the deviation gradually decreases with an increase in the depth of the sound source

Infantile hemangioma models: is the needle in a haystack?

Abstract Infantile hemangioma (IH) is the most prevalent benign vascular tumor in infants, with distinct disease stages and durations. Despite the fact that the majority of IHs can regress spontaneously, a small percentage can cause disfigurement or even be fatal. The mechanisms underlying the development of IH have not been fully elucidated. Establishing stable and reliable IH models provides a standardized experimental platform for elucidating its pathogenesis, thereby facilitating the development of new drugs and the identification of effective treatments. Common IH models include the cell suspension implantation model, the viral gene transfer model, the tissue block transplantation model, and the most recent three-dimensional (3D) microtumor model. This article summarizes the research progress and clinical utility of various IH models, as well as the benefits and drawbacks of each. Researchers should select distinct IH models based on their individual research objectives to achieve their anticipated experimental objectives, thereby increasing the clinical relevance of their findings