14 research outputs found
Π ΠΈΡΡΠΎΡΠΈΠΈ ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ Π΄ΠΎΠ»ΠΆΠ½ΠΎΡΡΠ½ΡΡ Π»ΠΈΡ ΡΠ°ΠΌΠΎΠΆΠ΅Π½Π½ΡΡ ΠΎΡΠ³Π°Π½ΠΎΠ² Π² XIX-XX Π²Π΅ΠΊΠ°Ρ
The article considers materials that allow evaluating the way of establishment of medical service for customs authorities during the XIXβXX centuries. Material and methods. The study was conducted in a combination of the main methodological principles β historicism, objectivity, and comprehensiveness of the research. Materials stored in the funds of the Central Museum of the Federal Customs Service, electronic resources allowing access to the Full Collection of laws of the Russian Federation were considered. Results and discussion. Before the beginning of the 19th century there was virtually no medical care for customs offi cials. The key role in the establishment of medical service provision was played by the Β«Charter of frontier and port quarantinesΒ», which determined the presence of
doctors or staff-medics in the staff of Quarantine Offi ces, who were supposed to provide free of charge assistance to quarantined and quarantine survivors. Later, the emphasis in providing medical care for customs offi cials shifted to hospitals and military hospitals. Most likely, it was due to the huge length of the Russian Empire borders, along which the customs houses, customs outposts and posts were located. The changes in socio-political system in 1917 had
their effect on the processes occurring with the provision of medical services in the country and in the customs offi ce. In the period after the Great Patriotic War, me dical services to employees of the department began to be provided in the outpatient clinic created under the USSR Ministry of Foreign Trade, and since 1957 β in the outpatient clinics of the USSR State Committee on Foreign Economic Relations, as well as in the inpatient clinics which were part of the structure of the USSR Ministry of Health. Conclusion. In the Russian Empire, customs houses, customs outposts and posts were located on the border, designed to solve a complex of problems in the border areas. The study of the historical experience of their medical service allows us to make more rational managerial decisions at the level of the
Federal Customs Service in the future.. Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠΈΠ΅ ΠΎΡΠ΅Π½ΠΈΡΡ ΠΏΡΡΡ ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ°ΠΌΠΎΠΆΠ΅Π½Π½ΡΡ
ΠΎΡΠ³Π°Π½ΠΎΠ² Π½Π° ΠΏΡΠΎΡΡΠΆΠ΅Π½ΠΈΠΈ XIXβXX Π²Π². ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΈΠ½ΡΠΈΠΏΠΎΠ²: ΠΈΡΡΠΎΡΠΈΠ·ΠΌΠ°, ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, Π²ΡΠ΅ΡΡΠΎΡΠΎΠ½Π½ΠΎΡΡΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ. ΠΡΠ»ΠΈ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ, Π½Π°Ρ
ΠΎΠ΄ΡΡΠΈΠ΅ΡΡ Π½Π° Ρ
ΡΠ°Π½Π΅Π½ΠΈΠΈ Π² ΡΠΎΠ½Π΄Π°Ρ
Π¦Π΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΡΠ·Π΅Ρ Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ°ΠΌΠΎΠΆΠ΅Π½Π½ΠΎΠΉ ΡΠ»ΡΠΆΠ±Ρ, ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΠ΅ ΡΠ΅ΡΡΡΡΡ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠΈΠ΅ ΠΎΡΡΡΠ΅ΡΡΠ²ΠΈΡΡ Π΄ΠΎΡΡΡΠΏ ΠΊ ΠΠΎΠ»Π½ΠΎΠΌΡ ΡΠΎΠ±ΡΠ°Π½ΠΈΡ
Π·Π°ΠΊΠΎΠ½ΠΎΠ² Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΈΡ
ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΠΎ Π½Π°ΡΠ°Π»Π° XIX Π². ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠ΅ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠ΅ Π΄ΠΎΠ»ΠΆΠ½ΠΎΡΡΠ½ΡΡ
Π»ΠΈΡ ΡΠ°ΠΌΠΎΠΆΠ΅Π½Π½ΡΡ
ΠΎΡΠ³Π°Π½ΠΎΠ² ΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ ΠΎΡΡΡΡΡΡΠ²ΠΎΠ²Π°Π»ΠΎ. ΠΠ»ΡΡΠ΅Π²ΡΡ ΡΠΎΠ»Ρ Π² ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ ΡΡΠ³ΡΠ°Π» Β«Π£ΡΡΠ°Π² ΠΏΠΎΠ³ΡΠ°Π½ΠΈΡΠ½ΡΡ
ΠΈ ΠΏΠΎΡΡΠΎΠ²ΡΡ
ΠΠ°ΡΠ°Π½ΡΠΈΠ½ΠΎΠ²Β», ΠΊΠΎΡΠΎΡΡΠΉ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΠ» Π½Π°Π»ΠΈΡΠΈΠ΅ Π² ΡΡΠ°ΡΠ΅ ΠΠ°ΡΠ°Π½ΡΠΈΠ½Π½ΡΡ
ΠΊΠΎΠ½ΡΠΎΡ Π΄ΠΎΠΊΡΠΎΡΠΎΠ² ΠΈΠ»ΠΈ ΡΡΠ°Π±-Π»Π΅ΠΊΠ°ΡΠ΅ΠΉ, ΠΊΠΎΡΠΎΡΡΠΌ ΠΏΡΠ΅Π΄ΠΏΠΈΡΡΠ²Π°Π»ΠΎΡΡ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ ΠΏΠΎΠΌΠΎΡΡ Π±Π΅Π·Π²ΠΎΠ·ΠΌΠ΅Π·Π΄Π½ΠΎ Π»ΠΈΡΠ°ΠΌ, Π½Π°Ρ
ΠΎΠ΄ΡΡΠΈΠΌΡΡ Π½Π° ΡΠ»ΡΠΆΠ±Π΅ ΠΏΡΠΈ ΠΊΠ°ΡΠ°Π½ΡΠΈΠ½Π°Ρ
, ΠΈ Π»ΠΈΡΠ°ΠΌ, Π²ΡΠ΄Π΅ΡΠΆΠΈΠ²Π°ΡΡΠΈΠΌ ΠΊΠ°ΡΠ°Π½ΡΠΈΠ½Π½ΡΠΉ ΡΡΠΎΠΊ. Π Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΌ Π°ΠΊΡΠ΅Π½Ρ Π² ΠΎΠΊΠ°Π·Π°Π½ΠΈΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΠΏΠΎΠΌΠΎΡΠΈ Π΄Π»Ρ Π΄ΠΎΠ»ΠΆΠ½ΠΎΡΡΠ½ΡΡ
Π»ΠΈΡ ΡΠ°ΠΌΠΎΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ Π²Π΅Π΄ΠΎΠΌΡΡΠ²Π° Π±ΡΠ» ΡΠΌΠ΅ΡΠ΅Π½ Π½Π° Π±ΠΎΠ»ΡΠ½ΠΈΡΡ ΠΈ
Π²ΠΎΠ΅Π½Π½ΡΠ΅ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈ. Π‘ΠΊΠΎΡΠ΅Π΅ Π²ΡΠ΅Π³ΠΎ, ΡΡΠΎ Π±ΡΠ»ΠΎ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΠΎΠ³ΡΠΎΠΌΠ½ΠΎΠΉ ΠΏΡΠΎΡΡΠΆΠ΅Π½Π½ΠΎΡΡΡΡ Π³ΡΠ°Π½ΠΈΡ Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ ΠΈΠΌΠΏΠ΅ΡΠΈΠΈ,
Π²Π΄ΠΎΠ»Ρ ΠΊΠΎΡΠΎΡΡΡ
ΡΠ°ΡΠΏΠΎΠ»Π°Π³Π°Π»ΠΈΡΡ ΡΠ°ΠΌΠΎΠΆΠ½ΠΈ, ΡΠ°ΠΌΠΎΠΆΠ΅Π½Π½ΡΠ΅ Π·Π°ΡΡΠ°Π²Ρ ΠΈ ΠΏΠΎΡΡΡ. ΠΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΎΠ±ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ-ΠΏΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ
ΡΡΡΠΎΡ Π² 1917 Π³. ΠΎΠΊΠ°Π·Π°Π»ΠΎ ΡΠ²ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΠΏΡΠΎΡΠ΅ΡΡΡ, ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΡΡΠΈΠ΅ Ρ ΠΎΠΊΠ°Π·Π°Π½ΠΈΠ΅ΠΌ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΠΏΠΎΠΌΠΎΡΠΈ Π² ΡΡΡΠ°Π½Π΅ ΠΈ Π² ΡΠ°ΠΌΠΎΠΆΠ΅Π½Π½ΠΎΠΌ Π²Π΅Π΄ΠΎΠΌΡΡΠ²Π΅. Π ΠΏΠ΅ΡΠΈΠΎΠ΄ ΠΏΠΎΡΠ»Π΅ ΠΠ΅Π»ΠΈΠΊΠΎΠΉ ΠΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π²ΠΎΠΉΠ½Ρ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠ°Ρ ΠΏΠΎΠΌΠΎΡΡ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠ°ΠΌ Π²Π΅Π΄ΠΎΠΌΡΡΠ²Π° ΡΡΠ°Π»Π° ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡΡΡ Π² ΠΏΠΎΠ»ΠΈΠΊΠ»ΠΈΠ½ΠΈΠΊΠ΅, ΡΠΎΠ·Π΄Π°Π½Π½ΠΎΠΉ ΠΏΡΠΈ ΠΠΈΠ½ΠΈΡΡΠ΅ΡΡΡΠ²Π΅ Π²Π½Π΅ΡΠ½Π΅ΠΉ ΡΠΎΡΠ³ΠΎΠ²Π»ΠΈ Π‘Π‘Π‘Π , Π° Ρ 1957 Π³. β Π² ΠΏΠΎΠ»ΠΈΠΊΠ»ΠΈΠ½ΠΈΠΊΠ°Ρ
ΠΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΈΡΠ΅ΡΠ° Π‘Π‘Π‘Π ΠΏΠΎ Π²Π½Π΅ΡΠ½ΠΈΠΌ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠ²ΡΠ·ΡΠΌ, Π° ΡΠ°ΠΊΠΆΠ΅ Π² ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠ°Ρ
,
ΡΠΎΡΡΠΎΡΡΠΈΡ
Π² ΡΡΡΡΠΊΡΡΡΠ΅ ΠΠΈΠ½ΠΈΡΡΠ΅ΡΡΡΠ²Π° Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ Π‘Π‘Π‘Π . ΠΡΠ²ΠΎΠ΄Ρ. Π Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ ΠΈΠΌΠΏΠ΅ΡΠΈΠΈ Π½Π° Π³ΡΠ°Π½ΠΈΡΠ΅
ΡΠ°Π·ΠΌΠ΅ΡΠ°Π»ΠΈΡΡ ΡΠ°ΠΌΠΎΠΆΠ½ΠΈ, ΡΠ°ΠΌΠΎΠΆΠ΅Π½Π½ΡΠ΅ Π·Π°ΡΡΠ°Π²Ρ ΠΈ ΠΏΠΎΡΡΡ, ΠΏΡΠΈΠ·Π²Π°Π½Π½ΡΠ΅ ΡΠ΅ΡΠ°ΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌ Π½Π° ΠΏΡΠΈΠ³ΡΠ°Π½ΠΈΡΠ½ΡΡ
ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΡΡ
. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° ΠΈΡ
ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π² Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΌ Π±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ ΠΏΡΠΈΠ½ΠΈΠΌΠ°ΡΡ ΡΠΏΡΠ°Π²Π»Π΅Π½ΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π½Π° ΡΡΠΎΠ²Π½Π΅ Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ°ΠΌΠΎΠΆΠ΅Π½Π½ΠΎΠΉ ΡΠ»ΡΠΆΠ±Ρ
The history of establishment and development of medical care for customs officials in the XIXβXX centuries
Aim. The article considers materials that allow evaluating the way of establishment of medical service for customs authorities during the XIXβXX centuries. Material and methods. The study was conducted in a combination of the main methodological principles β historicism, objectivity, and comprehensiveness of the research. Materials stored in the funds of the Central Museum of the Federal Customs Service, electronic resources allowing access to the Full Collection of laws of the Russian Federation were considered. Results and discussion. Before the beginning of the 19th century there was virtually no medical care for customs officials. The key role in the establishment of medical service provision was played by the Β«Charter of frontier and port quarantinesΒ», which determined the presence of doctors or staff-medics in the staff of Quarantine Offices, who were supposed to provide free of charge assistance to quarantined and quarantine survivors. Later, the emphasis in providing medical care for customs officials shifted to hospitals and military hospitals. Most likely, it was due to the huge length of the Russian Empire borders, along which the customs houses, customs outposts and posts were located. The changes in socio-political system in 1917 had their effect on the processes occurring with the provision of medical services in the country and in the customs office. In the period after the Great Patriotic War, medical services to employees of the department began to be provided in the outpatient clinic created under the USSR Ministry of Foreign Trade, and since 1957 β in the outpatient clinics of the USSR State Committee on Foreign Economic Relations, as well as in the inpatient clinics which were part of the structure of the USSR Ministry of Health. Conclusion. In the Russian Empire, customs houses, customs outposts and posts were located on the border, designed to solve a complex of problems in the border areas. The study of the historical experience of their medical service allows us to make more rational managerial decisions at the level of the Federal Customs Service in the future. Β© 2021, LLC "IMC" Modern Clinical Medicine. All rights reserved
The problem of artistic image creating in the process of a teacher artist training
The article deals with the problem of artistic image creating in the studentsβ creative works as a productive source of an artistic-pedagogical development of the future teacher artist. An artistic image is the basis of any art form and occupies the leading part in the artwork as it has a vast and significant esthetic value, demonstrating the result of an artist life experience display. The analysis of the theoretical sources, university training internship and the process of creative works fulfillment in different art forms brought to light the undervaluation of the necessity of scientifically grounded pedagogical grounds creation which will allow to the utmost prepare the students to the artistic image creating. This determines the relevance of the ways developing of studentsβ readiness to create an artistic image and its implementation in creative activities
GILBERTβS SYNDROME IN CHILDREN: CONTEMPORARY DIAGNOSTIC POTENTIALITIES
Gilbertβs syndrome is a benign indirect hyperbilirubinemia of the hereditary nature, caused by deficiency of the enzyme uridindiphosphatglucuronitransferase. UGT1A1 gene is localized on chromosome 2q37. The most common is a defect in the promoter region of the gene pairs in the thymine-adenin. 200 children aged 8 to 16 years with clinical and laboratory manifestations of Gilbert syndrome have been examined. All children undergone to a genetic study. It was calculated that the external signs, the shown complaints and laboratory manifestations are not enough sensitive and specific. This suggests that these symptoms can not be used as criteria for diagnosis of the Gilbert syndrome. The obtained results allow to recommend that all children with hyperbilirubinemia and Gilbertβs syndrome suspected should undergo to a genetic research as a priority.Key words: liver, hyperbilirubinemia, Gilbert syndrome, gene UGT1A1, diagnosis, children
GILBERTβS SYNDROME IN CHILDREN: CONTEMPORARY DIAGNOSTIC POTENTIALITIES
Gilbertβs syndrome is a benign indirect hyperbilirubinemia of the hereditary nature, caused by deficiency of the enzyme uridindiphosphatglucuronitransferase. UGT1A1 gene is localized on chromosome 2q37. The most common is a defect in the promoter region of the gene pairs in the thymine-adenin. 200 children aged 8 to 16 years with clinical and laboratory manifestations of Gilbert syndrome have been examined. All children undergone to a genetic study. It was calculated that the external signs, the shown complaints and laboratory manifestations are not enough sensitive and specific. This suggests that these symptoms can not be used as criteria for diagnosis of the Gilbert syndrome. The obtained results allow to recommend that all children with hyperbilirubinemia and Gilbertβs syndrome suspected should undergo to a genetic research as a priority.Key words: liver, hyperbilirubinemia, Gilbert syndrome, gene UGT1A1, diagnosis, children
ΠΠΠΠ‘Π’ΠΠ ΠΠΠ ΠΠΠ― Π¦ΠΠΠΠΠ‘Π’Π¬ ΠΠΠΠΠΠ§ΠΠ‘ΠΠΠ₯ Π ΠΠΠΠΠ ΠΠ’ΠΠ ΠΠ«Π₯ ΠΠ ΠΠ―ΠΠΠΠΠΠ Π‘ΠΠΠΠ ΠΠΠ ΠΠΠΠ¬ΠΠΠ Π Π£ ΠΠΠ’ΠΠ
Gilbertβs syndrome is a benign indirect hyperbilirubinemia of the hereditary nature, caused by deficiency of the enzyme uridindiphosphatglucuronitransferase. UGT1A1 gene is localized on chromosome 2q37. The most common is a defect in the promoter region of the gene pairs in the thymine-adenin. 200 children aged 8 to 16 years with clinical and laboratory manifestations of Gilbert syndrome have been examined. All children undergone to a genetic study. It was calculated that the external signs, the shown complaints and laboratory manifestations are not enough sensitive and specific. This suggests that these symptoms can not be used as criteria for diagnosis of the Gilbert syndrome. The obtained results allow to recommend that all children with hyperbilirubinemia and Gilbertβs syndrome suspected should undergo to a genetic research as a priority.Key words: liver, hyperbilirubinemia, Gilbert syndrome, gene UGT1A1, diagnosis, children.Π‘ΠΈΠ½Π΄ΡΠΎΠΌ ΠΠΈΠ»ΡΠ±Π΅ΡΠ° β Π΄ΠΎΠ±ΡΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ Π½Π΅ΠΏΡΡΠΌΠ°Ρ Π³ΠΈΠΏΠ΅ΡΠ±ΠΈΠ»ΠΈΡΡΠ±ΠΈΠ½Π΅ΠΌΠΈΡ Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ°, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½Π°Ρ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΡΡ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ° ΡΡΠΈΠ΄ΠΈΠ½Π΄ΠΈΡΠΎΡΡΠ°ΡΠ³Π»ΡΠΊΡΡΠΎΠ½ΠΈΠ»ΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Ρ. ΠΠ΅Π½ UGT1A1 Π»ΠΎΠΊΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½ Π½Π° 2q37 Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠ΅. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ Π΄Π΅ΡΠ΅ΠΊΡ Π½Π° ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ½ΠΎΠΌ ΡΡΠ°ΡΡΠΊΠ΅ Π³Π΅Π½Π° Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΠΏΠ°ΡΡ ΡΠΈΠΌΠΈΠ½-Π°Π΄Π΅Π½ΠΈΠ½. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 200 Π΄Π΅ΡΠ΅ΠΉ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 8 Π΄ΠΎ 16 Π»Π΅Ρ, ΠΈΠΌΠ΅ΡΡΠΈΡ
ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΠΠΈΠ»ΡΠ±Π΅ΡΠ°. ΠΡΠ΅ΠΌ Π΄Π΅ΡΡΠΌ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅. ΠΡΡΡΠΈΡΠ°Π½ΠΎ, ΡΡΠΎ Π²Π½Π΅ΡΠ½ΠΈΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ, ΠΏΡΠ΅Π΄ΡΡΠ²Π»ΡΠ΅ΠΌΡΠ΅ ΠΆΠ°Π»ΠΎΠ±Ρ ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΈΠΌΠ΅ΡΡ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΡΡ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ. ΠΡΠΎ Π³ΠΎΠ²ΠΎΡΠΈΡ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ Π΄Π°Π½Π½ΡΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ Π½Π΅ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΊΠ°ΠΊ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΠΠΈΠ»ΡΠ±Π΅ΡΠ°. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΠΎΠ²Π°ΡΡ Π²ΡΠ΅ΠΌ Π΄Π΅ΡΡΠΌ Ρ Π³ΠΈΠΏΠ΅ΡΠ±ΠΈΠ»ΠΈΡΡΠ±ΠΈΠ½Π΅ΠΌΠΈΠ΅ΠΉ ΠΈ ΠΏΠΎΠ΄ΠΎΠ·ΡΠ΅Π½ΠΈΠ΅ΠΌ Π½Π° ΡΠΈΠ½Π΄ΡΠΎΠΌ ΠΠΈΠ»ΡΠ±Π΅ΡΠ° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ°ΠΊ ΠΏΡΠΈΠΎΡΠΈΡΠ΅ΡΠ½ΠΎΠ΅.ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΠΏΠ΅ΡΠ΅Π½Ρ, Π³ΠΈΠΏΠ΅ΡΠ±ΠΈΠ»ΠΈΡΡΠ±ΠΈΠ½Π΅ΠΌΠΈΡ, ΡΠΈΠ½Π΄ΡΠΎΠΌ ΠΠΈΠ»ΡΠ±Π΅ΡΠ°, Π³Π΅Π½ UGT1A1, Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ°, Π΄Π΅ΡΠΈ. (ΠΠ΅Π΄ΠΈΠ°ΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡ. β 2011; 8 (4): 101β104