Reduction of the Vibrations Caused by Transport to the General Post-Office of Moscow

After the completion of base reinforcement with cast-in-place piles, instrumental analysis of foundation vibration parameters was made on the basis of the vibration survey results. The analysis showed a considerable decrease in the level of vibrations caused by transport

La2CuO4 as a Promising Oxygen Carrier for CLOU Process

The orthorhombic Ruddlesden-Popper phase La2CuO4±δ with the Cmce space group was obtained by a solid-state reaction route. Thermochemical data were calculated for the reaction of lanthanum cuprate formation Thermogravimetric measurements show the oxygen content is close to stoichiometric. Cyclic CLOU experiment was carried out to determine a specific oxygen capacity (ΔW0 exceeding 3.9%), as well as oxygen nonstoichiometry (δ) of La2CuO4±δ. The combustion rate of methane at 950 °C in the CLOU cycle about 0.5 1/min for one mole of lanthanum cuprate was achieved. © 2020 American Institute of Physics Inc.. All rights reserved.The authors appreciate the support of this work by the Russian Science Foundation under grant N 19-79-10147

Influence of RARα gene on MDR1 expression and P-glycoprotein function in human leukemic cells

BACKGROUND: Multidrug resistance (MDR) phenotype of malignant cells is the major problem in the chemotherapy of neoplasia. The treatment of leukemia with retinoids is aimed on the induction of leukemic cells differentiation. However the interconnections between retinoid regulated differentiation of leukemic cells and regulation of MDR remains unclear. METHODS: Four lines of cultured leukemic cells of diverse types of differentiation were infected with RARα gene and stable transfectants were isolated. We investigated the differentiation of these cells as well as the expression of RARα and MDR1 genes and P-glycoprotein (Pgp, MDR protein) functional activity in these cells. RESULTS: All RARα transfected sublines demonstrated the increase in the quantity of RARα mRNA. All these sublines became more differentiated. Intrinsic activity of MDR1 gene (but not Pgp functional activity) was increased in one of the transfectants. All-trans-retinoic acid (ATRA) induced Pgp activity in two of three infectants to a larger extent than in parental cells. CONCLUSION: The data show that RARα regulates MDR1/ Pgp activity in human leukemic cells, in the first place, Pgp activity induced by ATRA. These results show that RARα overexpression in leukemic cells could result in MDR

Interaction between UN and CdCl2 in molten LiCl-KCl eutectic. I. Experiment at 773 K

The interaction between UN and CdCl2 in the LiCl-KCl molten eutectic was studied at 773 K. The reaction was controlled by sampling the melt, as well as by analysis of the resulting precipitate. The process was shown to proceed according to several parallel reactions. The summary reaction was determined to have two stages: a fast one and a slow one. The 19–53% UN → UCl3 conversion was obtained for the molar ratio of CdCl2/UN = 1.22–14.9. The rest of UN converts into the precipitate of complex composition (UNCl + U2N3 + U4N7 + UN2). The increase in the CdCl2/UN molar ratio from 1.22 to 14.9 resulted in the decrease in duration of the first “fast” stage of the process from 18 h to 1 h. © 201

Interaction between UN and CdCl2 in Molten LiCl–KCl Eutectic. II. Experiment at 1023 K

The interaction between UN and CdCl2 in the LiCl–KCl molten eutectic was studied at 1023 K. The chlorination was monitored by sampling and recording the redox potential of the medium. At 1023 K the chlorination of UN with cadmium chloride in the molten LiCl–KCl eutectic proceeds completely and results in the formation of uranium chlorides. The melts of the LiCl–KCl–UCl3 or LiCl–KCl–UCl4 compositions can be obtained by the end of experiment depending on the presence of metallic cadmium in the reaction zone. The higher the concentration of the chlorinating agent, the faster the reaction rate. At [CdCl2]/[UN] = 1.65 (10% excess) the reaction proceeds to completion in about 7.5 h. At [CdCl2]/[UN] = 7 the complete chlorination takes 2.5–3 h. © 2021.The authors gratefully acknowledge for analytical support of the Shared Access Centre "Composition of Compounds" of the Institute of High Temperature Electrochemistry of the Ural Branch of the Russian Academy of Sciences. The present research was partially performed within the Proryv (Breakthrough) project of State Atomic Energy Corporation Rosatom

Novel method of silicon synthesis by CVD

Silicon fibers were synthesized by a novel CVD method including in the interaction of aluminum monofluoride with silicon oxide, the final product containing nanofibers in an amount of 15 wt. %. The possibility of selective reduction of silicon oxide from the chamotte refractory plate was also demonstrated. Si was characterized by SEM and XRD. Thermodynamics and mechanism of silicon fiber formation were also considered. © 2019 Author(s)

Another positivity proof and gravitational energy localizations

Two locally positive expressions for the gravitational Hamiltonian, one using 4-spinors the other special orthonormal frames, are reviewed. A new quadratic 3-spinor-curvature identity is used to obtain another positive expression for the Hamiltonian and thereby a localization of gravitational energy and positive energy proof. These new results provide a link between the other two methods. Localization and prospects for quasi-localization are discussed.Comment: 14 pages REVTe

The study of TIM polymer composite materials thermal conductivity

Support by the Ministry of Education and Science of the Russian Federation is gratefully acknowledged: calculation results (chapter 3.1) were obtained under research project # 3.6064.2017/8.9 and experimental results (chapter 3.2) - under project # 3.10704.2018/11.12

A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA) n Repeats Associated with Friedreich’s Ataxia

Expansions of microsatellite repeats are responsible for numerous hereditary diseases in humans, including myotonic dystrophy and Friedreich's ataxia. Whereas the length of an expandable repeat is the main factor determining disease inheritance, recent data point to genomic trans modifiers that can impact the likelihood of expansions and disease progression. Detection of these modifiers may lead to understanding and treating repeat expansion diseases. Here, we describe a method for the rapid, genome-wide identification of trans modifiers for repeat expansion in a yeast experimental system. Using this method, we found that missense mutations in the endoribonuclease subunit (Ysh1) of the mRNA cleavage and polyadenylation complex dramatically increase the rate of (GAA) n repeat expansions but only when they are actively transcribed. These expansions correlate with slower transcription elongation caused by the ysh1 mutation. These results reveal an interplay between RNA processing and repeat-mediated genome instability, confirming the validity of our approach. Keywords: genome instability; repeat expansion; RNA polyadenylation; RNA processing; transcription-replication conflicts; Friedreich’s ataxia; DNA double-strand breaks; trans-modifiers of repeat expansions; genetic screen; whole-genome sequencin

Procedural law development stages

The procedural legal norms play a very important role in ensuring optimal conditions for legal regulation, bear the main burden of the normative way of strengthening the rule of law, ensuring the rights, freedoms and legitimate interests of citizens. It is obvious that it is impossible to determine the trends in the procedural law development as an independent legal unit, to predict ways of optimizing and unifying certain process types in different legal families without a historical excursio