An evaluation of waste plastic in asphalt pavement towards a circular economy

Incorporating waste plastic into asphalt pavement is an evolving recycling strategy based on a circular economy approach. Dow has cooperated with MU to use optimal recycle plastic to target better pavement performance with less plastic leaking pollution. The goal is to find the optimal method to cooperate waste plastic with asphalt mixture, that is, an economical and environment-friendly way to target better mixture performance. Linear low-density polyethylene (LLDPE) and waste Polyethylene Terephthalate (PET) is the main plastic used in this project. Other additives (GTR, ElvaloyTM, and PPA) are also added to the mixture by dry process or wet process with the goal to improve the compatibility of plastic in the asphalt mixture. Various binder tests were conducted to evaluate the effect of LLDPE and PET modified binder by a wet process. AASHTO Superpave binder performance grading (PG) tests (Viscosity, DSR, BBR) test was utilized to characterize the workability, high-temperature (rutting) performance, and low temperature (cracking) performance. AASHTO Superpave method was performed to explore the LLDPE modified mixture performance with MoDOT criteria. Rutting resistance, cracking resistance at different temperatures were studied with a suite of laboratory tests, such as the Hamburg Wheel Tracking test (HWT), DC(T) test, IDEAL-CT test. Water samples from the rutting test and the permeability test were also further tested for microplastic detection. In terms of performance grade (PG) of chemically treated waste PET modification by wet process, this study is analogous to Leng's study (2018). Waste PET modification, up to 15% by weight of the binder, slightly increases the workability, high temperature, and low-temperature performance. Appreciate range for the amount of waste plastic was determined to be 2-3% by weight of the bitumen regard to PG performance. Elvaloy (PPA)-only or LLDPE pellet-only modified binder increases binder viscosity, which indicates a harder binder at the same temperature. Thus, the fail temperature from the DSR test at high temperature and intermediate temperature also improve. The increase in viscosity from the additives has a negative effect on the m value and stiffness of BBR test results. The combination of both LLDPE pellets and Elvaloy (PPA) made the binder even stiffer with viscosity increasing from 0.421 pa*s to 1.319 pa*s, which is more than three times. The addition of plastic by dry process affected specimens in mixture volumetric properties and performance test results. Melted plastic remains very viscous and dense and was not coated on the dense-graded aggregates used in this study. Plastic modified asphalt mixtures decreased the theoretical maximum gravity of the mixture for the volumetric property. Performance tests results show that plastic modified mixture greatly improve rutting resistance with rut depth from 17.1mm to 0.9 mm, which satisfied the MODOT criteria of 12.5 mm rut depth and enhance low- temperature cracking resistance to some degree. Even the CT index of LLDPE modified mixtures fails to meet the recommended threshold of MODOT, the CT index improves with the increase of LLDPE amount and the decrease of LLDPE size. It's also worth mentioning that the smaller size of LLDPE also helps to disperse itself in asphalt mixture, which produces a more stable and reliable asphalt mixture in the long term. Even stiffer with viscosity increasing from 0.421 pa*s to 1.319 pa*s, which is more than three times. The addition of plastic by dry process affected specimens in mixture volumetric properties and performance test results. Melted plastic remains very viscous and dense and was not coated on the dense-graded aggregates used in this study. Plastic modified asphalt mixtures decreased the theoretical maximum gravity of the mixture for the volumetric property. Performance tests results show that plastic modified mixture greatly improve rutting resistance with rut depth from 17.1mm to 0.9 mm, which satisfied the MODOT criteria of 12.5 mm rut depth and enhance low- temperature cracking resistance to some degree. Even the CT index of LLDPE modified mixtures fails to meet the recommended threshold of MODOT, the CT index improves with the increase of LLDPE amount and the decrease of LLDPE size. It's also worth mentioning that the smaller size of LLDPE also helps to disperse itself in asphalt mixture, which produces a more stable and reliable asphalt mixture in the long term.Includes bibliographical references (pages 31-33)

Deep Heterogeneous Hashing for Face Video Retrieval

Retrieving videos of a particular person with face image as a query via hashing technique has many important applications. While face images are typically represented as vectors in Euclidean space, characterizing face videos with some robust set modeling techniques (e.g. covariance matrices as exploited in this study, which reside on Riemannian manifold), has recently shown appealing advantages. This hence results in a thorny heterogeneous spaces matching problem. Moreover, hashing with handcrafted features as done in many existing works is clearly inadequate to achieve desirable performance for this task. To address such problems, we present an end-to-end Deep Heterogeneous Hashing (DHH) method that integrates three stages including image feature learning, video modeling, and heterogeneous hashing in a single framework, to learn unified binary codes for both face images and videos. To tackle the key challenge of hashing on the manifold, a well-studied Riemannian kernel mapping is employed to project data (i.e. covariance matrices) into Euclidean space and thus enables to embed the two heterogeneous representations into a common Hamming space, where both intra-space discriminability and inter-space compatibility are considered. To perform network optimization, the gradient of the kernel mapping is innovatively derived via structured matrix backpropagation in a theoretically principled way. Experiments on three challenging datasets show that our method achieves quite competitive performance compared with existing hashing methods.Comment: 14 pages, 17 figures, 4 tables, accepted by IEEE Transactions on Image Processing (TIP) 201

Policy-driven or market-driven? A new perspective on the development of China’s cruise industry

The past 15 years have witnessed the rapid development of China’s cruise industry from scratch and the formation of a policy system in the cruise industry, reflecting the shift of the Chinese government’s attitude towards the cruise industry from wait-and-see, recognition and encouragement to active support. The paper conducts a statistical analysis of 128 policies related to the cruise industry issued by China’s administrative departments at all levels. It is found that the release of policies synchronizes with the development of the cruise industry, with each one providing feedback to the other. The policies do not exhibit a time lag with respect to their effects. The evolution of policy types from macro-level guidance to concrete operation is rapid, with the policy structure gradually improving. In line with current characteristics of the development of China’s cruise industry, the themes of the policies concentrate on five areas: cruise tourism services and products, port construction and development, cruise industry chain expansion, cruise industry environment and cruise industry management. However, there is still a lack of adequate policies to support and guide the industrial upgrading of cruise operation and cruise construction and its green and low-carbon development. In addition, the paper points out the main directions of future policy formulation

The impact of statin use before intensive care unit admission on patients with acute kidney injury after cardiac surgery

Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common and serious complication after cardiac surgery. The influence of statin use before surgery on the renal outcome of patients undergoing cardiac surgery is controversial. The purpose of this study was to evaluate the effect of statins on postoperative renal outcomes in patients undergoing cardiac surgery.Methods: We included CSA-AKI patients in the Medical Information Mart for Intensive Care (MIMIC)—IV database and were divided into statin group and non-statin group according to whether they used statins before entering intensive care units (ICU). The main outcomes were hospitalization and 30-day mortality, and the secondary outcomes were 60-day mortality and 90-day mortality. We used propensity score matching (PSM) to adjust for confounding factors. The 95% confidence interval (CI) and risk ratio (RO) were calculated by the COX proportional regression model. At the same time, stratified analysis was used to explore whether the relationship between the statins use before intensive care units and mortality was different in each subgroup and whether the relationship between different doses of Atorvastatin and mortality was different.Result: We identified 675 pre-ICU statin users and 2095 non-statin users. In the COX proportional regression model, pre-ICU statin use was associated with decreased in-hospital (HR = 0.407, 95%confidence interval 0.278–0.595, p < 0.001) and 30-day mortality (HR = 0.407, 95%CI 0.279–0.595, p < 0.001). The survival rate of patients who took statins before entering ICU was significantly higher than that of those who did not use statins at 30 days, 60 days and 90 days. There is a significant interaction between patients with aged>65 years (HR = 0.373, 95%CI 0.240–0.581, p < 0.001), Acute kidney injury grade I (HR = 0.244, 95%CI 0.118–0.428, p < 0.001), and without post-myocardial infarction syndrome (HR = 0.344, 95%CI 0.218–0.542, p < 0.001). The mortality in hospital and 60 days of CSA-AKI patients treated with ≥80 mg Atorvastatin before operation was significantly reduced (p < 0.05).Conclusion: The pre-ICU statin use was significantly associated with decreased risk in hospital and 30-day mortality. The preoperative use of ≥80 mg Atorvastatin may improve the prognosis of CSA-AKI

Unequal Perylene Diimide Twins in a Quadruple Assembly

Natural light-harvesting (LH) systems can divide identical dyes into unequal aggregate states, thereby achieving intelligent "allocation of labor". From a synthetic point of view, the construction of such kinds of unequal and integrated systems without the help of proteinaceous scaffolding is challenging. Here, we show that four octatetrayne-bridged ortho-perylene diimide (PDI) dyads (POPs) self-assemble into a quadruple assembly (POP)4 both in solution and in the solid state. The two identical PDI units in each POP are compartmentalized into weakly coupled PDIs (P520) and closely stacked PDIs (P550) in (POP)4 . The two extreme pools of PDI chromophores were unambiguously confirmed by single-crystal X-ray crystallography and NMR spectroscopy. To interpret the formation of the discrete quadruple assembly, we also developed a two-step cooperative model. Quantum-chemical calculations indicate the existence of multiple couplings within and across P520 and P550, which can satisfactorily describe the photophysical properties of the unequal quadruple assembly. This finding is expected to help advance the rational design of dye stacks to emulate functions of natural LH systems.</p

Is knowledge retained by healthcare providers after training? A pragmatic evaluation of drug-resistant tuberculosis management in China.

OBJECTIVES: Considering the urgent need of training to improve standardised management of drug-resistant infectious disease and the lack of evidence on the impact of training, this study evaluates whether training participants' knowledge on multidrug-resistant tuberculosis (MDR-TB) is improved immediately and a year after training. SETTING AND PARTICIPANTS: The study involved 91 MDR-TB healthcare providers (HCPs), including clinical doctors, nurses and CDC staff, who attended a new MDR-TB HCP training programme in Liaoning and Jiangxi provinces, China. MAIN OUTCOME MEASURES: A phone-based assessment of participants' long-term retention of knowledge about MDR-TB management was conducted in July 2017, approximately 1 year after training. The proportion of correct responses in the long-term knowledge assessment was compared with a pretraining test and an immediate post-training test using a χ2 test. Factors influencing participants' performance in the long-term knowledge assessment were analysed using linear regression. RESULTS: Across both provinces, knowledge of definitions of drug-resistant TB, standardised MDR-TB case detection protocols and laboratory diagnosis was improved 1 year after the training by 14.5% (p=0.037), 32.4% (p<0.001) and 31% (p<0.001) relative to pretraining. However, compared with immediately after training, the knowledge of the three topics declined by 26.5% (p=0.003), 19.8% (p=0.018) and 52.7% (p<0.001) respectively in Jiangxi, while no significant decline was observed in Liaoning. Additionally, we found that obtaining a higher score in the long-term knowledge assessment was associated with longer years of clinical experience (coefficient=0.51; 95 CI% 0.02 to 0.99; p=0.041) and attending training in Liaoning (coefficient=0.50; 95% CI 0.14 to 0.85; p=0.007). CONCLUSION: Our study, the first to assess knowledge retention of MDR-TB HCPs 1 year after training, showed an overall positive long-term impact of lecture-style group training on participants' knowledge. Knowledge decline 1 year after training was observed in one province, Jiangxi, and this may be partly addressed by targeted support to HCPs with fewer years of clinical experience

whu-nercms at trecvid2021:instance search task

We will make a brief introduction of the experimental methods and results of the WHU-NERCMS in the TRECVID2021 in the paper. This year we participate in the automatic and interactive tasks of Instance Search (INS). For the automatic task, the retrieval target is divided into two parts, person retrieval, and action retrieval. We adopt a two-stage method including face detection and face recognition for person retrieval and two kinds of action detection methods consisting of three frame-based human-object interaction detection methods and two video-based general action detection methods for action retrieval. After that, the person retrieval results and action retrieval results are fused to initialize the result ranking lists. In addition, we make attempts to use complementary methods to further improve search performance. For interactive tasks, we test two different interaction strategies on the fusion results. We submit 4 runs for automatic and interactive tasks respectively. The introduction of each run is shown in Table 1. The official evaluations show that the proposed strategies rank 1st in both automatic and interactive tracks.Comment: 9 pages, 4 figure

Impact of old age on resectable colorectal cancer outcomes

Objective This study was performed to identify a reasonable cutoff age for defining older patients with colorectal cancer (CRC) and to examine whether old age was related with increased colorectal cancer-specific death (CSD) and poor colorectal cancer-specific survival (CSS). Methods A total of 76,858 eligible patients from the surveillance, epidemiology, and end results (SEER) database were included in this study. The Cox proportional hazard regression model and the Chow test were used to determine a suitable cutoff age for defining the older group. Furthermore, a propensity score matching analysis was performed to adjust for heterogeneity between groups. A competing risk regression model was used to explore the impact of age on CSD and non-colorectal cancer-specific death (non-CSD). Kaplan–Meier survival curves were plotted to compare CSS between groups. Also, a Cox regression model was used to validate the results. External validation was performed on data from 1998 to 2003 retrieved from the SEER database. Results Based on a cutoff age of 70 years, the examined cohort of patients was classified into a younger group (n = 51,915, <70 years of old) and an older group (n = 24,943, ≥70 years of old). Compared with younger patients, older patients were more likely to have fewer lymph nodes sampled and were less likely to receive chemotherapy and radiotherapy. When adjusted for other covariates, age-dependent differences of 5-year CSD and 5-year non-CSD were significant in the younger and older groups (15.84% and 22.42%, P < 0.001; 5.21% and 14.21%, P < 0.001). Also an age of ≥70 years remained associated with worse CSS comparing with younger group (subdistribution hazard ratio, 1.51 95% confidence interval (CI) [1.45–1.57], P < 0.001). The Cox regression model as a sensitivity analysis had a similar result. External validation also supported an age of 70 years as a suitable cutoff, and this older group was associated with having reduced CSS and increased CSD. Conclusions A total of 70 is a suitable cutoff age to define those considered as having elderly CRC. Elderly CRC was associated with not only increased non-CSD but also with increased CSD. Further research is needed to provide evidence of whether cases of elderly CRC should receive stronger treatment if possible

High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells

While inflammation is considered a central component in the development in diabetic nephropathy, the mechanism remains unclear. The NLRP3 inflammasome acts as both a sensor and a regulator of the inflammatory response. The NLRP3 inflammasome responds to exogenous and endogenous danger signals, resulting in cleavage of procaspase-1 and activation of cytokines IL-1β, IL-18, and IL-33, ultimately triggering an inflammatory cascade reaction. This study observed the expression of NLRP3 inflammasome signaling stimulated by high glucose, lipopolysaccharide, and reactive oxygen species (ROS) inhibitor N-acetyl-L-cysteine in glomerular mesangial cells, aiming to elucidate the mechanism by which the NLRP3 inflammasome signaling pathway may contribute to diabetic nephropathy. We found that the expression of thioredoxin-interacting protein (TXNIP), NLRP3, and IL-1β was observed by immunohistochemistry in vivo. Simultaneously, the mRNA and protein levels of TXNIP, NLRP3, procaspase-1, and IL-1β were significantly induced by high glucose concentration and lipopolysaccharide in a dose-dependent and time-dependent manner in vitro. This induction by both high glucose and lipopolysaccharide was significantly inhibited by N-acetyl-L-cysteine. Our results firstly reveal that high glucose and lipopolysaccharide activate ROS/TXNIP/ NLRP3/IL-1β inflammasome signaling in glomerular mesangial cells, suggesting a mechanism by which inflammation may contribute to the development of diabetic nephropathy