The Role of Lactic Acid Adsorption by Ion Exchange Chromatography

Background: The polyacrylic resin Amberlite IRA-67 is a promising adsorbent for lactic acid extraction from aqueous solution, but little systematic research has been devoted to the separation efficiency of lactic acid under different operating conditions. Methodology/Principal Findings: In this paper, we investigated the effects of temperature, resin dose and lactic acid loading concentration on the adsorption of lactic acid by Amberlite IRA-67 in batch kinetic experiments. The obtained kinetic data followed the pseudo-second order model well and both the equilibrium and ultimate adsorption slightly decreased with the increase of the temperature at 293–323K and 42.5 g/liter lactic acid loading concentration. The adsorption was a chemically heterogeneous process with a mean free energy value of 12.18 kJ/mol. According to the Boyd _ plot, the lactic acid uptake process was primarily found to be an intraparticle diffusion at a lower concentration (,50 g/liter) but a film diffusion at a higher concentration (.70 g/liter). The values of effective diffusion coefficient D i increased with temperature. By using our Equation (21), the negative values of DGu and DHu revealed that the adsorption process was spontaneous and exothermic. Moreover, the negative value of DSu reflected the decrease of solid-liquid interface randomness at the solid-liquid interface when adsorbing lactic acid on IRA-67. Conclusions/Significance: With the weakly basic resin IRA-67, in situ product removal of lactic acid can be accomplishe

Knowledge, Attitude and Uptake of Pap Smear among Female Healthcare Professionals in a Nigerian Teaching Hospital

Background: Despite the high prevalence of cervical cancer (CC) in Nigeria, the uptake of screening services, including Pap smear, remains poor, even amongst healthcare providers. Objective: To assess Pap smear knowledge, attitude, and uptake among female healthcare professionals (FHPs). Methods: A cross-sectional descriptive study was conducted at the University of Ilorin Teaching Hospital (UITH), Kwara State, Nigeria, using a self-administered questionnaire. Results: A majority (343, 98.6%) of the FHPs knew Pap smear. Five (26.3%) medical laboratory scientists did not know what a Pap smear was. All the nurses, doctors, pharmacists, physiotherapists and medical social workers knew Pap smear. Only a fifth (71; 20.4%) of the FHPs had ever done a Pap smear. The most common reason cited for not having done a Pap smear was lack of time (109; 31.3%). There was a relationship between age and uptake of Pap smear (p = 0.024). Only 188 (54%) of the FHPs had ever recommended Pap smear to other women. Conclusion: Despite the high level of knowledge of Pap smear amongst FHPs in Nigeria, attitude and uptake remain poor. There is a need for further training and education of FHPs on the benefits of CC screening to increase their uptake and improve their effectiveness in promoting positive attitudes towards CC screening and prevention in the general population

Empirical model for the assessment of climate change impacts on spatial pattern of water availability in Nigeria

Rising temperatures and changing rainfall patterns due to global warming would affect sustainability in water resources in many regions. This change would impact several sectors, particularly the agricultural and water resources. The major objective of the present study is to model the impacts of climate change on spatial variability in water sustainability of Nigeria. Gauge based gridded rainfall data of global precipitation climatology centre (GPCC) and temperature data of climate research unit (CRU) for the period 1901–2010 and total water storage (TWS) anomaly data of Gravity Recovery and Climate Experiment (GRACE) for the period 2002–2016 were used for this purpose. The concept of reliability-resiliency-vulnerability was used for the assessment of sustainability in water resources. Machine learning models were used for the development of empirical models for the simulation of TWS from GPCC rainfall and CRU temperature. Finally, the multi-model ensemble mean projections of rainfall and temperature of four GCMs namely MRI-CGCM3, HadGEM2-ES, CSIRO-Mk3-6-0 and CESM1-CAM5 were used in the model for the assessment of climate change impact on water sustainability. The results revealed the declination of TWS in Nigeria up to -12 m during the rainy periods in some parts. Spatial assessment of the changes in TWS for the future shows the northeast, southeast and south-south parts would mostly experience decreases in TWS. Water sustainability will be low in these areas and some other parts of the country for the future