On the benefits of philosophy as a way of life in a general introductory course

Philosophy as a way of life (PWOL) places investigations of value, meaning, and the good life at the center of philosophical investigation, especially of one’s own life. I argue PWOL is compatible with general introductory philosophy courses, further arguing that PWOL-based general introductions have several philosophical and pedagogical benefits. These include the ease with which high impact practices, situated skill development, and students’ ability to ‘think like a disciplinarian’ may be incorporated into such courses, relative to more traditional introductory courses, as well as the demonstration of philosophy’s value to students by explicitly tying philosophical investigation to students own lives

Luminosity function of [O ii] emission-line galaxies in the MassiveBlack-II simulation

We examine the luminosity function (LF) of [O II] emission-line galaxies in the high-resolution cosmological simulation MassiveBlack-II (MBII). From the spectral energy distribution of each galaxy, we select a sub-sample of star-forming galaxies at 0.06 ≤ z ≤ 3.0 using the [O II] emission line luminosity L([O II]). We confirm that the specific star formation rate matches that in the Galaxy And Mass Assembly survey. We show that the [O II] LF at z = 1.0 from the MBII shows good agreement with the LFs from several surveys below L([O II]) = 1043.0 erg s−1 while the low redshifts (z ≤ 0.3) show an excess in the prediction of bright [O II] galaxies, but still displaying a good match with observations below L([O II]) = 1041.6 erg s−1. Based on the validity in reproducing the properties of [O II] galaxies at low redshift (z ≤ 1), we forecast the evolution of the [O II] LF at high redshift (z ≤ 3), which can be tested by upcoming surveys such as the Hobby-Eberly Telescope Dark Energy Experiment and Dark Energy Spectroscopic Instrument. The slopes of the LFs at bright and faint ends range from −3 to −2 showing minima at z = 2. The slope of the bright end evolves approximately as (z + 1)−1 at z ≤ 2 while the faint end evolves as ∼3(z + 1)−1 at 0.6 ≤ z ≤ 2. In addition, a similar analysis is applied for the evolution of [O III] LFs, which is to be explored in the forthcoming survey Wide-Field InfraRed Survey Telescope-Astrophysics Focused Telescope Assets. Finally, we show that the auto-correlation function of [O II] and [O III] emitting galaxies shows a rapid evolution from z = 2 to 1

Contamination by neonicotinoid insecticides in Barn owls (Tyto alba) and Alpine swifts (Tachymarptis melba)

Acknowledgements We thank all the students and volunteers who helped us in their fields. This study was supported by a Swiss National Science Foundation overheads grant, a grant from the Federal Office for the Environment and an SNSF-förderungs professor grant to FH. Photographs used in the graphical abstract are copyrights of Alexandre Roulin, Pierre Bize and Shirley Laurent. The authors bear sole responsibility for the content and declare no conflict of interest.Peer reviewedPublisher PD

LKB1 signaling is activated in CTNNB1 -mutated HCC and positively regulates β-catenin-dependent CTNNB1 -mutated HCC

International audienceCTNNB1‐mutated HCC. They were found to be well‐differentiated, almost never steatotic, and often cholestatic, with a microtrabecular or acinar growth pattern. Here, we investigated whether LKB1, which controls energy metabolism, cell polarity, and cell growth, mediates the specific phenotype of CTNNB1‐mutated HCC. The LKB1 protein was overexpressed in CTNNB1‐mutated HCC and oncogenic activation of β‐catenin in human HCC cells induced the post‐transcriptional accumulation of the LKB1 protein encoded by the LKB1 (STK11) gene. Hierarchical clustering, based on the expression of a murine hepatic liver Lkb1 (Stk11) signature in a human public dataset, identified a HCC cluster, composed of almost all the CTNNB1‐mutated HCC, that expresses a hepatic liver LKB1 program. This was confirmed by RT‐qPCR of an independent cohort of CTNNB1‐mutated HCC and the suppression of the LKB1‐related profile upon β‐catenin silencing of CTNNB1‐mutated human hepatoma cell lines. Previous studies described an epistatic relationship between LKB1 and CTNNB1 in which LKB1 acts upstream of CTNNB1. Thus, we also analyzed the consequences of Lkb1 deletion on the zonation of hepatic metabolism, known to be the hallmark of β‐catenin signaling in the liver. Lkb1 was required for the establishment of metabolic zonation in the mouse liver by positively modulating β‐catenin signaling. We identified positive reciprocal cross talk between the canonical Wnt pathway and LKB1, both in normal liver physiology and during tumorigenesis that likely participates in the amplification of the β‐catenin signaling by LKB1 and the distinctive phenotype of the CTNNB1‐mutated HCC

Étudiant(e)s de niveau collégial ayant des incapacités College students with disabilities

"La présente recherche a été subventionnée par le Ministère de l'éducation dans le cadre du Programme d'aide à la recherche sur l'enseignement et l'apprentissage (PAREA)"Titre de l'écran-titre (visionné le 8 déc. 2006)Également disponible en version papierBibliogr

Un projet collaboratif avec les jeunes inuits, leurs familles et communautés : la persévérance scolaire sous l’angle des pratiques éducatives informelles, de la recherche scientifique communautaire et des cheminements éducatifs

Comprend des références bibliographiquesDes études sur la persévérance scolaire dans l’Inuit Nunangat ont relevé des lacunes en matière d’opportunités éducatives qui se perpétuent pour les jeunes et les jeunes adultes Inuits. En même temps, de nombreuses initiatives et projets sans précédent ont vu le jour ces dernières années, sous l’impulsion des Inuits et de leurs communautés. Ceux-ci répondent aux préoccupations de la communauté tout en réduisant ce déficit d’opportunités, et contribuent à l’autodétermination et à la mise en valeur de la culture. L’objectif de ce projet était de décrire les contributions éducatives des programmes et des projets menés par les Inuits dans trois communautés, sous l’angle de l’apprentissage tout au long de la vie et de la persévérance, tels que fondés sur l’Inuit Qaujimajatuqangit (IQ) ou l’épistémologie inuite