Negative Correlation between the Diffusion Coefficient and Transcriptional Activity of the Glucocorticoid Receptor

The glucocorticoid receptor (GR) is a transcription factor, which interacts with DNA and other cofactors to regulate gene transcription. Binding to other partners in the cell nucleus alters the diffusion properties of GR. Raster image correlation spectroscopy (RICS) was applied to quantitatively characterize the diffusion properties of EGFP labeled human GR (EGFP-hGR) and its mutants in the cell nucleus. RICS is an image correlation technique that evaluates the spatial distribution of the diffusion coefficient as a diffusion map. Interestingly, we observed that the averaged diffusion coefficient of EGFP-hGR strongly and negatively correlated with its transcriptional activities in comparison to that of EGFP-hGR wild type and mutants with various transcriptional activities. This result suggests that the decreasing of the diffusion coefficient of hGR was reflected in the high-affinity binding to DNA. Moreover, the hyper-phosphorylation of hGR can enhance the transcriptional activity by reduction of the interaction between the hGR and the nuclear corepressors

Impact of System and Diagnostic Errors on Medical Litigation Outcomes: Machine Learning-Based Prediction Models

No prediction models using use conventional logistic models and machine learning exist for medical litigation outcomes involving medical doctors. Using a logistic model and three machine learning models, such as decision tree, random forest, and light-gradient boosting machine (LightGBM), we evaluated the prediction ability for litigation outcomes among medical litigation in Japan. The prediction model with LightGBM had a good predictive ability, with an area under the curve of 0.894 (95% CI; 0.893-0.895) in all patients' data. When evaluating the feature importance using the SHApley Additive exPlanation (SHAP) value, the system error was the most significant predictive factor in all clinical settings for medical doctors' loss in lawsuits. The other predictive factors were diagnostic error in outpatient settings, facility size in inpatients, and procedures or surgery settings. Our prediction model is useful for estimating medical litigation outcomes

Spectral flow of fermions in the \CP^2 (anti-)instanton, and the sphaleron with vanishing topological charge

The spectral flow is ubiquitous in the physics of soliton-fermion interacting systems. We study the spectral flows related to a continuous deformation of background soliton solutions, which enable us to develop insight into the emergence of fermionic zero modes and the localization mechanism of fermion densities. We investigate a \CP^2 nonlinear sigma model in which there are the (anti-) instantons and also the sphalerons with vanishing topological charge. The standard Yukawa coupling of the fermion successfully generates infinite towers of the spectra and the spectral flow is observed when increasing the size of such solitons. At that moment, the localization of the fermions on the solitons emerges. The avoided crossings are also observed in several stages of the exchange of the flows, they are indicating a manifestation of the fermion exchange of the localizing nature.Comment: 16 pages, 10 figures, v2: minor correction

F-term Moduli Stabilization and Uplifting

We study K\"ahler moduli stabilization in IIB superstring theory. We propose a new moduli stabilization mechanism by the supersymmetry-braking chiral superfield which is coupled to K\"ahler moduli in K\"ahler potential. We also study uplifting of the Large Volume Scenario (LVS) by it. In both cases, the form of superpotential is crucial for moduli stabilization. We confirm that our uplifting mechanism does not destabilize the vacuum of the LVS drastically.Comment: 22 pages, 2 figure

Fundamental Characteristics of a Cylindrical Linear Pulse Motor for the Artificial Heart

A new actuator using a cylindrical linear pulse motor for the artificial heart is proposed with descriptions of the principle of operation, theoretical expression of thrust, and experimental results. The actuator has a simple configuration and its size is much smaller than the ordinary external backup facility using a pneumatic power. The actuator consists chiefly of a linear pulse motor and two rooms of sacs for the right and left ventricles. Some problems have been found to be solved before the actuator can be applied to the actual artificial heart.Article信州大学工学部紀要 56: 59-72 (1984)departmental bulletin pape

Improvement in Efficiency of Wireless Power Transfer of Magnetic Resonant Coupling Using Magnetoplated Wire

Wireless power transfer is expected in the use of an electric vehicle and a chip card. However, it requires a high efficiency and takes a long distance. In this paper, we propose the use of a magnetoplated wire (MPW), which is a copper wire (COW) whose circumference is plated with a magnetic thin film to improve transmission efficiency. The MPW can reduce resistances due to the proximity effect comparison with the COW. The inner diameter of COW and MPW coils is d(i) = 37 mm and their number of turns is n = 10. As a result, the resistances of the COW and MPW at the frequency f = 12 MHz are 6.8 and 4.1 Omega, respectively, which show a reduction of 40%. The quality factors of the COW and MPW at the frequency f = 12 MHz are 83 and 138, respectively, which show an increase of 66%. The efficiencies of the COW and MPW at a transmission distance of 10 mm are 69.8% and 77.7%, respectively, which show an increase of 7.9%.ArticleIEEE TRANSACTIONS ON MAGNETICS. 47(10):4445-4448 (2011)journal articl

Quantum manipulation of two-electron spin states in metastable double quantum dots

We studied experimentally the dynamics of the exchange interaction between two antiparallel electron spins in a so-called metastable double quantum dot where coupling to the electron reservoirs can be ignored. We demonstrate that the level of control of such a double dot is higher than in conventional double dots. In particular, it allows to couple coherently two electron spins in an efficient manner following a scheme initially proposed by Loss and DiVincenzo. The present study demonstrates that metastable quantum dots are a possible route to increase the number of coherently coupled quantum dots.Comment: 5 pages, 4 figure