The smoothed plots of the estimated hazard of overall and each reactions to iodinated contrast media.

<p>The curves illustrate smoothed plot of the estimated hazard of (A) overall adverse reactions, (B) hypersensitivity, (C) physiologic and (D) other adverse reaction to iodinated contrast media in patients with no previous exposure to contrast media. The hazard function (solid line) and 95% confidence intervals (black dotted line) were estimated by a smoothing spline with three knots. Gray dotted lines show the hazard at the initial exposure.</p

The cumulative probabilities of overall and each reactions to iodinated contrast media.

<p>Graphs illustrate (A) the cumulative probability of overall adverse reactions to iodinated contrast media and (B) the cumulative probabilities of hypersensitivity, physiologic and other adverse reactions to iodinated contrast media.</p

Subsequent contrast media injections and subsequent adverse reaction to iodinated contrast media.

<p>Subsequent contrast media injections and subsequent adverse reaction to iodinated contrast media.</p