Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

油症認定患者及び未認定者の血液中ダイオキシン類濃度と傾向 （2001〜2017年度）

We performed congener specific analysis of dioxins using HRGC/HRMS and determined their concentrations in blood samples collected from approx. 1,700 persons during annual Yusho examinations between 2001 and 2017. When concentration of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) was compared in seven Yusho patients undergoing examinations among the seventeen years, the longitudinal concentrations in the respective individuals hardly changed over these years. Mean concentration of 2,3,4,7,8-PeCDF in blood from Yusho patients registered by annual inspections for Yusho was calculated as 110 pg/g, which was 80％ higher than the mean value of 17 pg/g in normal controls, and the rates of persons with blood 2,3,4,7,8-PeCDF concentrations below 50 pg/g in the entire patients occupied approx. 60％. On the other hand, in a subset of Yusho patients registered by the supplemental criteria revised on 2012, it was found that the median values of concentration of 2,3,4,7,8-PeCDF were similar to the those of normal controls.はじめに / 実験方法 / 結果及び考察 / 総