Relativistic Particle Acceleration in a Folded Current Sheet

Two-dimensional particle simulations of a relativistic Harris current sheet of pair plasmashave demonstrated that the system is unstable to the relativistic drift kink instability (RDKI) and that a new kind of acceleration process takes place in the deformed current sheet. This process contributes to the generation of non-thermal particles and contributes to the fast magnetic dissipation in the current sheet structure. The acceleration mechanism and a brief comparison with relativistic magnetic reconnection are presented.Comment: 11 preprint pages, including 3 .eps figure

Phenotypic Plasticity of Mouse Spermatogonial Stem Cells

BACKGROUND:Spermatogonial stem cells (SSCs) continuously undergo self-renewal division to support spermatogenesis. SSCs are thought to have a fixed phenotype, and development of a germ cell transplantation technique facilitated their characterization and prospective isolation in a deterministic manner; however, our in vitro SSC culture experiments indicated heterogeneity of cultured cells and suggested that they might not follow deterministic fate commitment in vitro. METHODOLOGY AND PRINCIPAL FINDINGS:In this study, we report phenotypic plasticity of SSCs. Although c-kit tyrosine kinase receptor (Kit) is not expressed in SSCs in vivo, it was upregulated when SSCs were cultured on laminin in vitro. Both Kit(-) and Kit(+) cells in culture showed comparable levels of SSC activity after germ cell transplantation. Unlike differentiating spermatogonia that depend on Kit for survival and proliferation, Kit expressed on SSCs did not play any role in SSC self-renewal. Moreover, Kit expression on SSCs changed dynamically once proliferation began after germ cell transplantation in vivo. CONCLUSIONS/SIGNIFICANCE:These results indicate that SSCs can change their phenotype according to their microenvironment and stochastically express Kit. Our results also suggest that activated and non-activated SSCs show distinct phenotypes

Neuronal clearance of amyloid-β by endocytic receptor LRP1

Alzheimer\u27s disease (AD) is the most prevalent form of dementia in the elderly population. Accumulation, aggregation, and deposition of amyloid-β (Aβ) peptides generated through proteolytic cleavage of amyloid precursor protein (APP) are likely initiating events in the pathogenesis of AD. While Aβ production is accelerated in familial AD, increasing evidence indicates that impaired clearance of Aβ is responsible for late-onset AD. Because Aβ is mainly generated in neurons, these cells are predicted to have the highest risk of encountering Aβ among all cell types in the brain. However, it is still unclear whether they are also involved in Aβ clearance. Here we show that receptor-mediated endocytosis in neurons by the low-density lipoprotein receptor-related protein 1 (LRP1) plays a critical role in brain Aβ clearance. LRP1 is known to be an endocytic receptor for multiple ligands including Aβ. Conditional knock-out of Lrp1 in mouse forebrain neurons leads to increased brain Aβ levels and exacerbated amyloid plaque deposition selectively in the cortex of amyloid model APP/PS1 mice without affecting Aβ production. In vivo microdialysis studies demonstrated that Aβ clearance in brain interstitial fluid is impaired in neuronal Lrp1 knock-out mice. Because the neuronal LRP1-deletion did not affect the mRNA levels of major Aβ degrading enzymes, neprilysin and insulin-degrading enzyme, the disturbed Aβ clearance is likely due to the suppression of LRP1-mediated neuronal Aβ uptake and degradation. Together, our results demonstrate that LRP1 plays an important role in receptor-mediated clearance of Aβ and indicate that neurons not only produce but also clear Aβ

Particle Acceleration and Magnetic Dissipation in Relativistic Current Sheet of Pair Plasmas

We study linear and nonlinear development of relativistic and ultrarelativistic current sheets of pair plasmas with antiparallel magnetic fields. Two types of two-dimensional problems are investigated by particle-in-cell simulations. First, we present the development of relativistic magnetic reconnection, whose outflow speed is an order of the light speed c. It is demonstrated that particles are strongly accelerated in and around the reconnection region, and that most of magnetic energy is converted into "nonthermal" part of plasma kinetic energy. Second, we present another two-dimensional problem of a current sheet in a cross-field plane. In this case, the relativistic drift kink instability (RDKI) occurs. Particle acceleration also takes place, but the RDKI fast dissipates the magnetic energy into plasma heat. We discuss the mechanism of particle acceleration and the theory of the RDKI in detail. It is important that properties of these two processes are similar in the relativistic regime of T > mc^2, as long as we consider the kinetics. Comparison of the two processes indicates that magnetic dissipation by the RDKI is more favorable process in the relativistic current sheet. Therefore the striped pulsar wind scenario should be reconsidered by the RDKI.Comment: To appear in ApJ vol. 670; 60 pages, 27 figures; References and typos are fixe

Faster Family-wise Error Control for Neuroimaging with a Parametric Bootstrap

In neuroimaging, hundreds to hundreds of thousands of tests are performed across a set of brain regions or all locations in an image. Recent studies have shown that the most common family-wise error (FWE) controlling procedures in imaging, which rely on classical mathematical inequalities or Gaussian random field theory, yield FWE rates that are far from the nominal level. Depending on the approach used, the FWER can be exceedingly small or grossly inflated. Given the widespread use of neuroimaging as a tool for understanding neurological and psychiatric disorders, it is imperative that reliable multiple testing procedures are available. To our knowledge, only permutation joint testing procedures have been shown to reliably control the FWER at the nominal level. However, these procedures are computationally intensive due to the increasingly available large sample sizes and dimensionality of the images, and analyses can take days to complete. Here, we develop a parametric bootstrap joint testing procedure. The parametric bootstrap procedure works directly with the test statistics, which leads to much faster estimation of adjusted \emph{p}-values than resampling-based procedures while reliably controlling the FWER in sample sizes available in many neuroimaging studies. We demonstrate that the procedure controls the FWER in finite samples using simulations, and present region- and voxel-wise analyses to test for sex differences in developmental trajectories of cerebral blood flow

Three Dimensional Polarimetric Neutron Tomography of Magnetic Fields

Through the use of Time-of-Flight Three Dimensional Polarimetric Neutron Tomography (ToF 3DPNT) we have for the first time successfully demonstrated a technique capable of measuring and reconstructing three dimensional magnetic field strengths and directions unobtrusively and non-destructively with the potential to probe the interior of bulk samples which is not amenable otherwise. Using a pioneering polarimetric set-up for ToF neutron instrumentation in combination with a newly developed tailored reconstruction algorithm, the magnetic field generated by a current carrying solenoid has been measured and reconstructed, thereby providing the proof-of-principle of a technique able to reveal hitherto unobtainable information on the magnetic fields in the bulk of materials and devices, due to a high degree of penetration into many materials, including metals, and the sensitivity of neutron polarisation to magnetic fields. The technique puts the potential of the ToF time structure of pulsed neutron sources to full use in order to optimise the recorded information quality and reduce measurement time.Comment: 12 pages, 4 figure

Classifying the Arithmetical Complexity of Teaching Models

This paper classifies the complexity of various teaching models by their position in the arithmetical hierarchy. In particular, we determine the arithmetical complexity of the index sets of the following classes: (1) the class of uniformly r.e. families with finite teaching dimension, and (2) the class of uniformly r.e. families with finite positive recursive teaching dimension witnessed by a uniformly r.e. teaching sequence. We also derive the arithmetical complexity of several other decision problems in teaching, such as the problem of deciding, given an effective coding $\{\mathcal L_0,\mathcal L_1,\mathcal L_2,\ldots\}$ of all uniformly r.e. families, any $e$ such that $\mathcal L_e = \{L^e_0,L^e_1,\ldots,\}$, any $i$ and $d$, whether or not the teaching dimension of $L^e_i$ with respect to $\mathcal L_e$ is upper bounded by $d$.Comment: 15 pages in International Conference on Algorithmic Learning Theory, 201

Abstractness of human speech sound representations

We argue, based on a study of brain responses to speech sound differences in Japanese, that memory encoding of functional speech sounds-phonemes-are highly abstract. As an example, we provide evidence for a theory where the consonants/p t k b d g/ are not only made up of symbolic features but are underspecified with respect to voicing or laryngeal features, and that languages differ with respect to which feature value is underspecified. In a previous study we showed that voiced stops are underspecified in English [Hestvik, A., & Durvasula, K. (2016). Neurobiological evidence for voicing underspecification in English. Brain and Language], as shown by asymmetries in Mismatch Negativity responses to /t/ and /d/. In the current study, we test the prediction that the opposite asymmetry should be observed in Japanese, if voiceless stops are underspecified in that language. Our results confirm this prediction. This matches a linguistic architecture where phonemes are highly abstract and do not encode actual physical characteristics of the corresponding speech sounds, but rather different subsets of abstract distinctive features

MUSCLE ACTIVITY IN THE SUBJECTS WITH FUNCTIONAL INSTABILITY OF THE ANKLE DURING A SINGLE-LEG DROP JUMP

Ankle sprain is one of the most common injuries experienced sporting participation, and Hertel J (2002) reported it’s recurrence rate is very high( 47-73 %). Presence of residual pain and functional problems (recurrent complaints of “giving way” or repeated sprain) following inversion ankle sprains are often reported. These symptoms of repeated complaints of “giving way” and/or recurrent sprains have been termed functional instability (FI) of the ankle joint with the report of Freeman, Dean and Hanham (1965). Including the report of Konradsen and Ravn (1991) and Hertsell and Spaulding (1999), There are many studies of muscle functions such as muscle strength, muscle activity, muscle response time of ankle joint evertor in the subjects with FI of the ankle joint. However, a few studies have researched muscle activity in the situation actually occurs ankle sprain such as jump landing on the subjects with FI of ankle joint. The purpose of this study was to identify differences in ankle joint muscle activity in subjects with FI of the ankle joint during a single-leg drop jump landing