Quantitative Analysis of Isolated Single-Wall Carbon Nanotubes with Their Molar Absorbance Coefficients

The molar absorbance coefficients of metallic, semiconducting, and (6,5) chirality enriched single-wall carbon nanotubes were evaluated by a spray technique combined with atomic force microscopy. Single-wall carbon nanotubes with isolated and a single predominant electronic type were obtained by using the density-gradient ultracentrifugation technique. In the visible region, all coefficients had similar values around 2–5 × 109/mL mol−1 cm−1, independent of their diameter distribution and the electronic types of single-wall carbon nanotubes, and the εS22/εM11  and εS11/εM11 were estimated to be 1.0 and 4.0, respectively. The coefficient strongly depends on the length of single-wall carbon nanotubes, independent of their electronic types and chirality

NIRS as a tool for assaying emotional function in the prefrontal cortex

Despite having relatively poor spatial and temporal resolution, near-infrared spectroscopy (NIRS) has several methodological advantages compared with other non-invasive measurements of neural activation. For instance, the unique characteristics of NIRS give it potential as a tool for investigating the role of the prefrontal cortex (PFC) in emotion processing. However, there are several obstacles in the application of NIRS to emotion research. In this mini-review, we discuss the findings of studies that used NIRS to assess the effects of PFC activation on emotion. Specifically, we address the methodological challenges of NIRS measurement with respect to the field of emotion research, and consider potential strategies for mitigating these problems. In addition, we show that two fields of research, investigating (i) biological predisposition influencing PFC responses to emotional stimuli and (ii) neural mechanisms underlying the bi-directional interaction between emotion and action, have much to gain from the use of NIRS. With the present article, we aim to lay the foundation for the application of NIRS to the above-mentioned fields of emotion research

Possible neural correlate of young child attachment to mother in 4 to 5 year olds

Attachment between mothers and infants is the most primitive and primary form of human social relationship. Recently, it hasbeen reported that the anterior prefrontal cortex (APFC) of infants younger than 3 years old may play an important function informing attachments to their mothers. However, little is known about how the neural correlates of attachment develop after 3years of age. Bowlby argued that there is a critical period, between birth and 2.5 years (0?30 months), for attachments to formand if it does not form in this time then it is not possible to develop thereafter. The current study investigated the role of the APFCin the attachment of 5 year olds to their mothers. Subjects included 18 young children (5.0 ± 0.4 years), whose mothers’ smileswere video recorded. By means of near-infrared spectroscopy (NIRS), we measured APFC activation in the children while viewingtheir mother smiling, and compared the activation with that resulting from an unfamiliar mother smiling. We found significantincreases in right APFC activation in these 5 year olds in response to their mother’s smile. Furthermore, the APFC response tomothers’ smiles did not change as a function of age between 4 and 5 years old. These results suggest that the right APFC is stillinvolved in young childrens’ attachment to their mothers until at least 5 years of age

Fetal response to induced maternal emotions.

This study investigated the relationship between fetal movements and acute maternal emotional changes during pregnancy. Two empirically validated feature film clips were used for the external generation of two subjectively and facially well-characterized target emotions: happiness and sadness. We simultaneously monitored separate fetal arm, leg, and trunk movements by means of two ultrasound apparatuses while maternal emotions were manipulated by film clip presentation. The number of fetal arm movements, but not the duration, was increased when pregnant women were being shown a happy film. Both the number and the duration of fetal arm movements decreased with the sad film presentation. Neither the presentation of happiness nor the presentation of sadness affected fetal leg or trunk movements. These findings suggest that induced emotions in pregnant women primarily affect arm movements of their fetuses, and that positive and negative emotions have the opposite effects on fetus movement

Fetal Response to Mozart\u27s Music

Objective: This study aimed to determine whether fetal arm movements change when music is presented to the mother or directly to the fetus through the mother\u27s lower abdomen, and whether maternal mood influences changes in fetal arm movements. Methods: Using a diagnostic ultrasound apparatus, fetal arm movements were measured in 47 pregnant women in the 35-36th week of pregnancy. Subjects were divided into two groups: a maternal presentation group, in which the mothers listened to music through headphones; and a fetal presentation group, in which music was presented directly to the fetus through headphones placed on the mother\u27s abdomen. Fetal arm movements were observed and recorded by ultrasound for a total of 10 min (5 min without music followed by 5 min with music). The music used was Mozart\u27s Sonata for Two Pianos in D Major, K. 448. The Profile of Mood States-Brief Form (POMS) was used to investigate the influence of maternal mood on fetal arm movements. Results: In the maternal presentation group, changes in fetal arm movement did not differ between mothers with different moods. In the fetal presentation group, fetal arm movements increased when the mother was energetic and decreased when the mother lacked energy. Fetal arm movement also decreased when the mother had a high level of fatigue and increased when the mother had a low level of fatigue. Conclusion: Presenting music directly to the fetus while the mother is relaxed has the potential to increase fetal response to the music and may possibly promote fetal well-being

The Validity and Reliability of a Smartphone Application for Break-Point Angle Measurement during Nordic Hamstring Exercise

# Background A recently developed smartphone application (Nordic Angle) allows the automatic calculation of the break-point angle (BPA) during Nordic hamstring exercise (NHE) without transferring the collected data to a computer. The BPA is the point at which the hamstrings are unable to withstand force. However, the validity of the BPA values obtained by this method has not been examined. # Hypothesis/Purpose This study aimed to evaluate the validity and reliability of the Nordic Angle by comparing the BPA values of the Nordic Angle with those of two-dimensional motion analysis software that can calculate the angles and angular velocities of various joints. # Study Design Cohort assessing Validity and Reliability # Methods The validity of the Nordic Angle BPA data was verified by Spearman's correlation test for consistency with the movement analysis data, and the magnitude of the correlation was indicated by rs. The agreement between these measurements was examined using the Bland-Altman analysis. The reliability of the Nordic Angle and motion analysis was examined using the intraclass correlation coefficient (ICC) (1,k) based on data from repeated trials within a day. # Results Although the spearman correlation between the Nordic angle and the angle determined using motion analysis did not reach statistical significance (p = 0.052), a very large correlation was present (rs = 0.75). The difference between the mean values of the Nordic Angle and motion analysis was 0.4 ± 2.1°, and the limits of agreement ranged from -3.9° to 4.6°. In two BPA measurements, the Nordic Angle showed perfect reliability (ICC = 1.00, p \< 0.001), while motion analysis showed nearly perfect reliability (ICC = 0.97, p \< 0.001). # Conclusion The Nordic Angle, which has both validity and reliability, may be appropriate for field measurement because it allows immediate feedback of BPA and the measurement of many athletes. # Level of evidence 3b ©The Author(s

Lymphedema After Axillary Lymph Node Dissection in Breast Cancer: Prevalence and Risk Factors—A Single-Center Retrospective Study

Background: Lymphedema may develop when axillary lymph node dissection (ALND) injures and obstructs the lymph ducts in the upper limb. In patients with breast cancer, lymphedema is difficult to treat and can cause arm swelling, heaviness, and restricted movement. We aimed to identify the prevalence and risk factors for lymphedema after ALND in patients with breast cancer.Methods and Results: This retrospective study included 175 patients with breast cancer who underwent ALND in the Nagasaki University Hospital, Japan, between 2005 and 2018. Lymphedema was defined as symptomatic arm swelling with a >2-cm difference in the arm circumference between the affected and contralateral arms. Patients were divided into two groups according to the presence or absence of lymphedema. Surgical and pathological findings were compared between the two groups. Univariate and multivariate analyses were performed, including the chi-square test, Student’s t-test, and logistic regression analysis. Lymphedema was prevalent in 20% of the study participants, and the mean time interval from surgery to development of lymphedema was 479 days. In the univariate analysis, a body mass index of >26 kg/m2, smoking, radiotherapy (RT), and dissection of >18 axillary lymph nodes (ALNs) significantly increased the risk of lymphedema. In the multivariate analysis, smoking, RT, and dissection of >18 ALNs significantly increased the risk of lymphedema.Conclusions: The prevalence of lymphedema in our study was 20%. Our findings suggest that smoking, RT, and dissection of >18 ALNs are risk factors for lymphedema. Aggressive and empiric ALND might be associated with axillary lymph duct damage

No interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescents

Background: Identification of gene × environment interactions (G × E) for depression is a crucial step in ascertaining the mechanisms underpinning the disorder. Earlier studies have indicated strong genetic influences and numerous environmental risk factors. In relation to childhood and adolescent depression, evidence is accumulating that the quality of the parental environment is associated with serotonin biology in children. We hypothesized that maternal depression is a crucial environmental risk factor associated with serotonin-regulating genes.Methods: This study was designed to ascertain the G × E interaction for diagnosis of depression in a Japanese pediatric sample. DNA samples from 55 pediatric patients with depression and 58 healthy schoolchildren were genotyped for the 5-HTT (2 short (S) alleles at the 5-HTT locus) promoter serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphism. We examined whether an adverse parental environment, operationalized as the mother\u27s history of recurrent major depressive disorder, interacts with 5-HTTLPR polymorphism to predict patients\u27 depression symptoms.Results: Binary logistic regression analyses revealed that maternal depression (adversity), gender, and FSIQ significantly affect the diagnosis of depression among children and adolescents. However, no main effect was found for adversity or genotype. Results of multivariable logistic regression analyses using stepwise procedure have elicited some models with a good fit index, which also suggests no interaction between 5-HTTLPR and adversity on depression.Conclusions: To assess G × E interaction, data obtained from children and adolescents who had been carefully diagnosed categorically and data from age-matched controls were analyzed using logistic regression. Despite an equivocal interaction effect, adversity and gender showed significant main effects

Differential prefrontal response to infant facial emotions in mothers compared with non-mothers.

A considerable body of research has focused on neural responses evoked by emotional facial expressions, but little is known about mother-specific brain responses to infant facial emotions. We used near-infrared spectroscopy to investigate prefrontal activity during discriminating facial expressions of happy, angry, sad, fearful, surprised and neutral of unfamiliar infants and unfamiliar adults by 14 mothers and 14 age-matched females who have never been pregnant (non-mothers). Our results revealed that discriminating infant facial emotions increased the relative oxyHb concentration in mothers\u27 right prefrontal cortex but not in their left prefrontal cortex, compared with each side of the prefrontal cortices of non-mothers. However, there was no difference between mothers and non-mothers in right or left prefrontal cortex activation while viewing adult facial expressions. These results suggest that the right prefrontal cortex is involved in human maternal behavior concerning infant facial emotion discrimination