Study on Improvement of Indonesia Shipbuilding Productivity with Theory of Constraints

Indonesia is a big country having big population, huge area and huge Exclusive Economic Zone area. For world harmonized growth, it is quite important to realize steady economy growth on Indonesia. Growth of Indonesia’s shipbuilding industry specifically is an important part to achieve Indonesia’s maritime vision, but by far as for the shipbuilding market, 3 major countries, China, South Korea and Japan have obtained almost 100% share, which means it is quite difficult to increase the world share. In the volatile marine world, fluctuating oil price often affect production capacity, and investment decision is hard to get with TOP management. Indonesia shipbuilding industry has big mission under severe management and environmental condition. We clarify basic dilemma / conflict inhibiting the growth of Indonesia shipbuilding industry under assumption of severe management environmental condition, with Theory of Constraints (TOC). The basic dilemmas are solved by erasing the reason of existence of opposite activity and the Indonesia shipbuilding ever-lasting development logic is proposed with the solution of basic dilemma

Academic Society as a ‘place’ to Connect Educational Researchers and Practitioners: In the case of academic society relate to social studies education

This study examines on the role and meaning of academic societies as a “place” for connecting researchers and practitioners. We picked up two academic societies related to social studies education and from the changes in the way they handle their research frameworks. Throughout examining the previous literatures related to these two societies, there are two major findings. The first is that research frameworks could provide the standards for deciding good/bad research. Some frameworks can establish common standards for researchers and practitioners, while others could be designed to clarify the different roles of researchers andpractitioners. Secondly, there are research frameworks serve as indicators for organizing existing research works. This can be an administrative and intuitive framework, or it can be a topical or thematic framework in the context of academic trends

Development and Application of Social Studies Digital Contents for Inquiry Based Learning: A Case of “NONTA’s Classroom” and “Higashi-Hiroshima City Library Collaboration Seminar”

The purpose of this study is to develop digital contents that support inquiry based learning and to propose application examples of “local community studies” conducted in Japanese primary social studies education. For this reason, we set up a development project team by researchers and university students majoring in social studies education and developed digital contents over a year. In this project, we formulated five “design principles” for development. The contents were envisioned in consideration of the format, cooperation with social studies textbooks and supplementary readers for community studies, correspondence with the course of study, and the fairness of the areas handled. Finally, the digital contents which name is “NONTA’s Classroom” was developed and 10 keywords were released on the website. Along with the release, in cooperation with Higashi-Hiroshima City Library, we invited local elementary school students to use the digital contents and learn and verified the application and improvement of digital content. As a result of this research, 1)we conceived the design and concrete contents and structure of digital content that supports inquiry based learning and developed it. Also, 2)we specified an example of how to apply and confirmed its effectiveness

How to plan and conduct Japanese history lesson aiming to promote historical inquiry: A case of “Sekkanseiji To Insei”

This study proposes the Japanese history lesson plan integrating active historical inquiry by student themselves. Historical inquiry has been regarded as an important strategy to history education fostering democratic citizenship. However, the previous studies in Japan did not seem to clarify the characteristics of historical inquiry and how to apply in the classroom because most of them focused only on the motivation of students. We established the three principles to develop the lesson plan; 1） Procedural concepts are shown to the students explicitly; 2） Various resources is necessary for making diverse historical resources; 3）various activities for promoting active learning by students should be prepared. After conducting the lessons, we found that students actively engaged the class and develop their own historical interpretation. At the end of study, we proposed the future possibilities for bigger reform of history curriculum

A Japanese History lesson for understanding diversity

This study proposes the Japanese history lesson aiming for promoting deeper understanding diversity because the previous studies in relation to historical inquiry in Japan did not mention about connection with diversity. After conducting the lessons, we found that students mentioned the differences of people’s value between past and present based on the social structure and notions. At the end of study we suggested the reform of history education have more possibilities to develop democratic citizenship

Purification of enzymatically inactive peptidylarginine deiminase type 6 from mouse ovary that reveals hexameric structure different from other dimeric isoforms

The murine peptidylarginine deiminase (PAD) has five isoforms encoded by different genes and partici- pates in a variety of cellular functions through the citrullination of target proteins. The crystal structure of human PAD4 with a dimeric form was previously solved because of the enzyme’s relevance to rheuma- toid arthritis. PAD6, abundant in mouse oocytes and eggs, is believed to take part in early events of embryogenesis, but its biochemical properties are little understood. Here we have purified and charac- terized a recombinant PAD6. A PAD6 cDNA was cloned from mouse ovary RNA and expressed in Escherichia coli through pET29 and pGEX vectors. When benzoyl-L-arginine ethyl ester was used as a substrate, no appreciable activity was detected with a cell homogenate under conditions where a human PAD4 cDNA caused significant activity. Both pro- teins were affinity-purified to near homogeneity. The circular dichroism spectra of PAD6 and human PAD4 were similar in the far ultraviolet region. On molecular sieving, PAD6 was eluted faster than human PAD4. The cross-linking of PAD6 with dime- thyl suberimidate clearly showed six bands on an sodium dodecyl sulfate-polyacrylamide gel. These results indicate that PAD6 can constitute a hexameric structure. The purified PAD6 still showed no enzy- matic activity. This unique structure and loss in enzymatic activity is strongly suggested to favor the formation of egg cytoplasmic sheets as the architectu- ral protein

Investigation for the efficacy of COVID-19 vaccine in Japanese CKD patients treated with hemodialysis

Background: Dialysis patients are predisposed to severe disease and have a high mortality rate in coronavirus disease 2019 (COVID-19) due to their comorbidities and immunocompromised conditions. Therefore, dialysis patients should be prioritized for vaccination. This study aimed to examine how long the effects of the vaccine are maintained and what factors affect antibody titers. Methods: Hemodialysis patients (HD group) and age- and sex-matched non-dialysis individuals (Control group), receiving two doses of BNT162b2 vaccine, were recruited through the Japanese Society for Dialysis Therapy (JSDT) Web site in July 2021. Anti-SARS-CoV-2 immunoglobulin (IgG) (SARS-CoV-2 IgG titers) was measured before vaccination, 3 weeks after the first vaccination, 2 weeks after the second vaccination, and 3 months after the second vaccination, and was compared between Control group and HD group. Factors affecting SARS-CoV-2 IgG titers were also examined using multivariable regression analysis and stepwise regression analysis (least AIC). In addition, we compared adverse reactions in Control and HD groups and examined the relationship between adverse reactions and SARS-CoV-2 IgG titers. Results: Our study enrolled 123 participants in the Control group (62.6% men, median age 67.0 years) and 206 patients in the HD group (64.1% men, median age 66.4 years). HD group had significantly lower SARS-CoV-2 IgG titers at 3 weeks after the first vaccination (p < 0.0001), 2 weeks after second vaccination (p = 0.0002), and 3 months after the second vaccination (p = 0.045) than Control group. However, the reduction rate of SARS-CoV-2 IgG titers between 2 weeks and 3 months after the second vaccination was significantly smaller in HD group than in Control (p = 0.048). Stepwise regression analysis revealed that dialysis time was identified as the significant independent factors for SARS-CoV-2 IgG titers at 2 weeks after the second vaccination in HD group (p = 0.002) and longer dialysis time resulted in higher maximum antibody titers. The incidences of fever and nausea after the second vaccination were significantly higher in the HD group (p = 0.039 and p = 0.020). Antibody titers in those with fever were significantly higher than those without fever in both groups (HD: p = 0.0383, Control: p = 0.0096). Conclusion: HD patients had significantly lower antibody titers than age- and sex-matched non-dialysis individuals over 3 months after vaccination. Dialysis time was identified as a factor affecting SARS-CoV-2 IgG titers in HD group, with longer dialysis time resulting in higher maximum SARS-CoV-2 IgG titers

T-Cell Response and Antibody Production Induced by the COVID-19 Booster Vaccine in Japanese Chronic Kidney Disease Patients Treated with Hemodialysis

Humoral and cellular responses are critical in understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Here, we evaluated these responses in hemodialysis (HD) patients after the booster vaccination. SARS-CoV-2 immunoglobulin (IgG) levels, neutralizing antibody titers, and the T-SPOT®.COVID test (T-SPOT) were measured prior to, three weeks after, and three months after the booster administration. The HD group had significantly higher SARS-CoV-2 IgG levels and neutralizing antibody titers against the original strain at three weeks and three months after the booster vaccination compared to the control group, albeit the HD group had lower SARS-CoV-2 IgG levels and neutralizing antibody titers before the booster administration. Moreover, the HD group had significantly higher T-SPOT levels at all three time points compared to the control group. The HD group also had significantly higher local and systemic adverse reaction rates than the control group. By booster vaccination, HD patients could acquire more effective SARS-CoV-2-specific humoral and cellular immunity than the control group

Research Activities in the Department of Physical Therapy

[Introduction] It is already fifty years since the Japanese law of physical therapists and occupational therapists has been effective. The physical therapist is referred by the law as "the professionals who implements the physical therapy to persons with disabilities under the prescription of medical doctors". In fifty years, however, the target of physical therapy has been significantly expanded. The subject for physical therapy now includes the patients in acute disease just after the surgical operation in addition to those in rehabilitation stage. In other words, the physical therapy is now recognized as the indispensable intervention to the subject with acute as well as chronic disorders. On the other hand, due to a rapid transition of the society into the aged society, prevention of diseases, and decline of activity capacity due to the aging have become major issues for the physical therapy