5 research outputs found
The recovery rate of <sup>15</sup>N from DNJ in urine and feces until 48 hours after sample administration.
<p>The recovery rate of <sup>15</sup>N from DNJ in urine and feces until 48 hours after sample administration. After 12 hours fasting, the rats were received <sup>15</sup>N-labeled DNJ (10 mg). Urine and feces were collected and the amount of <sup>15</sup>N from DNJ was analyzed. (a) The time course of recovery rate of <sup>15</sup>N in urine. (b) Total recovery rate of <sup>15</sup>N in urine and feces. Results are given as means ± SE.</p
The aza-sugars composition of administration samples.
<p>The aza-sugars composition of administration samples.</p
The transition of plasma DNJ concentration.
<p>The rats received orally administered sucrose (2 g/kg B.W.) 15 minutes after each samples administration (equivalent to 5 mg DNJ or miglitol/kg B.W.). Blood was collected from tail venous vein and plasma DNJ or miglitol concentration was determined using LC-MS/MS. Results are given as means ± SE. Means without a common letter differ significantly (p < 0.05).</p
The chromatograms of administration samples.
<p>Aza-sugars in each sample were analyzed using LC-MS/MS.</p
The effects in suppressing the blood glucose in rats.
<p>The rats received orally administered sucrose (2 g/kg B.W.) 15 minutes after each samples administration (equivalent to 5 mg DNJ or miglitol/kg B.W.). Blood glucose levels were determined from tail blood sample. (a) is the transition of blood glucose concentration and (b) is area of under curve of blood glucose concentration. Results are given as means ± SE. * p < 0.05 versus control; ** p < 0.01 versus control.</p