Numerical Analysis on the He II Heat Transport in Channels with a Porous Spacer

Heat transport characteristics in a pressurized He II channel have been studied, using two-dimensional numerical code that is based on the two fluid model. In general, He II heat transport performance gets worse in a either long or narrow channel [1]. If a porous medium is used as a part of the channel to transfer heat to a next channel, it will be expected to improve the heat transport in the channel. In this study, numerical model was based on the channel formed by two FRP plates in parallel and a spacer was inserted in the middle of the channel to divide into two regions. A heater was placed in one of FRP plate to input heat to the channel. Two kinds of spacers were used in the analysis to compare heat transport characteristics; (l) porous spacer, (2) FRP spacer. The temperature distribution and flow velocity vectors of He II in the channel were calculated with a steady state heat input. According to the calculated results, the temperature increase of He II in the heated channel was suppressed in the case of a porous spacer. In addition, the mass flow induced by the thermo-mechanical effect of He II enhanced heat transport capability. The paper also discusses the He II flows within the channel

Discordant Immune Marker Expression Between Preoperatively Biopsied and Matched Surgically Resected Specimens in Patients With Oral Squamous Cell Carcinoma

Programmed cell death ligand 1 (PD-L1) expression and tumor-associated immune cell (TAIC) density can be the biomarkers of survival outcome and for predicting the efficacy of immune checkpoint inhibitors in oral squamous cell carcinoma (OSCC), but whether single biopsy accurately reflects the values of these parameters in resected specimens is unclear. To clarify this, we evaluated the concordance of immune marker expression (PD-L1, PD-1, CD3, CD4, CD8, and CD68) between 39 paired biopsied and surgically resected specimens obtained from patients with OSCC at Kobe City Medical Center General Hospital between July 2011 and January 2016. Immune marker expression was assessed using immunohistochemistry. PD-L1 expression was consistent between the biopsied and surgically resected specimens in only 76.9% of cases. TAIC density was significantly lower in biopsied than in surgically resected specimens. There was considerable discordance in immune marker expression between biopsied and surgically resected specimens. We should take into consideration that PD-L1 positivity and TAIC density would be underestimated by single small biopsies compared to the estimations by surgically resected specimens

General anesthesia of a Japanese infant with Barber-Say syndrome : a case report

Background: Barber-Say syndrome (BSS) is a very rare congenital disorder characterized by macrostomia, cutis laxa, and other features. We report our experience of performing general anesthesia on a Japanese child with BSS. Case presentation: A bilateral repair of the corners of the mouth under general anesthesia was planned for an 18-month-old male with macrostomia; the child was 75 cm in height and weighed 9.9 kg. As insertion of the peripheral intravenous catheter was difficult, it was inserted before the surgery by a pediatrician. The patient wore a mask and was ventilated manually after loss of consciousness with intravenous anesthesia. A mask for adults provided a superior fit and was effective in preventing air leakage from the corners of the mouth. After rocuronium was administered, the larynx was spread with a Macintosh laryngoscope. There was no laryngeal anatomical abnormality, and tracheal intubation was readily possible. The operation was completed without incident. Stiffening of both arms occurred for several seconds one hour after the operation ended, but the patient did not develop other complications. Conclusions: Mask ventilation and the insertion of an intravenous catheter may be difficult in the general anesthesia of patients with BSS, and anesthetic management requires caution

Design Window Analysis for the Helical DEMO Reactor FFHR-d1

Conceptual design activity for the LHD-type helical DEMO reactor FFHR-d1 has been conducted at the National Institute for Fusion Science under the Fusion Engineering Research Project since FY2010. In the first step of the conceptual design process, design window analysis was conducted using the system design code HELIOSCOPE by the “Design Integration Task Group”. On the basis of a parametric scan with the core plasma design based on the DPE (Direct Profile Extrapolation) method, a design point having a major radius of 15.6 m and averaged magnetic field strength at the helical coil winding center of 4.7 T was selected as a candidate. The validity of the design was confirmed through the analysis by the related task groups (in-vessel component, blanket, and superconducting magnet)

Reliable long-term operation of superconducting bus lines for the LHD

The Large Helical Device (LHD) is an experimental device for helical type fusion plasma in National Institute for Fusion Science and plasma experiments over 150,000 shots have been successfully conducted during twenty long-term plasma experimental campaigns. The LHD has two kinds of superconducting magnets and nine flexible superconducting bus lines with an average length of 55 m, which are utilized as a part of the current feeder system between the coils and the power sources. The superconducting bus lines consist of a pair of aluminum stabilized NbTi/Cu compacted stranded cable insulated electrically and coaxial five corrugated stainless steel tubes with two layers of vacuum insulations. The nominal current is 32 kA and the withstand voltage is 5 kV in 77 K gas helium. From the first experimental campaign, the superconducting bus lines have been stably operated at steady state by using automatic control. It is also confirmed that the status of the superconducting bus lines are kept good thanks to appropriate maintenances. As the results, the reliable operation of the superconducting bus lines has been achieved during the plasma experimental campaigns without any serious failure and the total operational time of the steady state cooling is approximately 58,000 hours

Distinct cell proliferation, myogenic differentiation, and gene expression in skeletal muscle myoblasts of layer and broiler chickens

Myoblasts play a central role during skeletal muscle formation and growth. Precise understanding of myoblast properties is thus indispensable for meat production. Herein, we report the cellular characteristics and gene expression profiles of primary-cultured myoblasts of layer and broiler chickens. Broiler myoblasts actively proliferated and promptly differentiated into myotubes compared to layer myoblasts, which corresponds well with the muscle phenotype of broilers. Transcriptomes of layer and broiler myoblasts during differentiation were quantified by RNA sequencing. Ontology analyses of the differentially expressed genes (DEGs) provided a series of extracellular proteins as putative markers for characterization of chicken myogenic cells. Another ontology analyses demonstrated that broiler myogenic cells are rich in cell cycle factors and muscle components. Independent of these semantic studies, principal component analysis (PCA) statistically defined two gene sets: one governing myogenic differentiation and the other segregating layers and broilers. Thirteen candidate genes were identified with a combined study of the DEGs and PCA that potentially contribute to proliferation or differentiation of chicken myoblasts. We experimentally proved that one of the candidates, enkephalin, an opioid peptide, suppresses myoblast growth. Our results present a new perspective that the opioids present in feeds may influence muscle development of domestic animals.Articlejournal articl

Effects of Subcooling on Lengths of Propagating Normal Zones in the LHD Helical Coils

Propagation of a short normal zone was observed in a helical coil of the Large Helical Device, when the coil was cooled with subcooled helium, of which the inlet and outlet temperatures are 3.2 K and below 4.0 K, respectively. The normal zone was induced at the bottom position of the coil. It propagated to only the downstream side of the current with recovery from the opposite side, and stopped after passing the outer equator of the torus. The induced balance voltage is obviously lower and the propagating time is shorter than those of propagating normal zones observed in the helical coil cooled with saturated helium at 4.4 K. According to the simulation of the propagation of a normal zone, it is considered that such a short normal zone at the current close to the minimum propagating current propagates without full transition to film boiling

Self-field measurements of an HTS twisted stacked-tape cable conductor

For a twisted stacked-tape cable (TSTC) conductor composed of REBCO tapes, self-field measurements were conducted with Hall sensors. In the measurements, a 650 mm diameter single turn coil wound with the TSTC conductor, which was made with 48 REBCO tapes whose width was 6 mm, was utilized as a test sample. Based on the measurement results, the current distribution of the TSTC conductor was investigated with analytical models. The analytical results indicate the current distribution of the TSTC is uniform under the condition that the operating current is 10 kA and the sample temperature is approximately 30 K. On the other hand, the current distribution is not uniform at the excitation and the degauss of the TSTC conductor with the ramp rate of 50 A/s

Engineering research and development of magnetically levitated high-temperature superconducting coil system for mini-RT project

A magnetically levitated superconducting coil system is being developed using high temperature superconductors for examining a new magnetic confinement of high-beta plasmas. A miniature double-pancake coil was fabricated with a Bi-2223 Ag-sheathed tape for the purpose of developing a floating control using laser displacement gauges. The coil was inductively excited with liquid nitrogen cooling and successfully levitated in the air. A persistent current switch is also being developed with a Bi-2223 Ag-0.3wt%Mn-sheathed tape, and a prototype model was successfully tested

Highly Efficient Liquid Hydrogen Storage System by Magnetic Levitation Using HTS Coils

Highly efficient liquid hydrogen storage system is studied with magnetic levitation using high-temperature superconducting (HTS) coils. The system also has high safety in case of emergency, such as an earthquake, with a seismic isolation to absorb vibrations provided by HTS levitation coils setup on the ground side. In such an emergency case, it is considered that a large amount of ac losses are generated in HTS coils, and the winding temperature may rise to lead to a coil quench. In this study, the self-oscillation-type heat pipe (OHP), whose thermal transport property is much greater than that of solid thermal conduction, is used to cool the coil windings. As a result, an HTS coil equipped with an OHP cooling system can be realized, supporting both low heat loads in the usual operation and high heat loads in an emergency