15 research outputs found

    First Total Synthesis of Hunanamycin A

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    The first total synthesis of hunanamycin A, an antibiotic natural product with a pyrido[1,2,3-<i>de</i>]quinoxaline-2,3-dione core from a marine-derived <i>Bacillus hunanensis</i>, is disclosed. The present effort provides access to sufficient amounts of scarce hunanamycin A for further biological evaluation and confirmation of the assigned absolute configuration. In addition, four new analogues of the natural product are reported
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