Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders.

Neuronal glucose transporter (GLUT) isoform 3 deficiency in null heterozygous mice led to abnormal spatial learning and working memory but normal acquisition and retrieval during contextual conditioning, abnormal cognitive flexibility with intact gross motor ability, electroencephalographic seizures, perturbed social behavior with reduced vocalization and stereotypies at low frequency. This phenotypic expression is unique as it combines the neurobehavioral with the epileptiform characteristics of autism spectrum disorders. This clinical presentation occurred despite metabolic adaptations consisting of an increase in microvascular/glial GLUT1, neuronal GLUT8 and monocarboxylate transporter isoform 2 concentrations, with minimal to no change in brain glucose uptake but an increase in lactate uptake. Neuron-specific glucose deficiency has a negative impact on neurodevelopment interfering with functional competence. This is the first description of GLUT3 deficiency that forms a possible novel genetic mechanism for pervasive developmental disorders, such as the neuropsychiatric autism spectrum disorders, requiring further investigation in humans

Tomographic RF Spectroscopy of a Trapped Fermi Gas at Unitarity

We present spatially resolved radio-frequency spectroscopy of a trapped Fermi gas with resonant interactions and observe a spectral gap at low temperatures. The spatial distribution of the spectral response of the trapped gas is obtained using in situ phase-contrast imaging and 3D image reconstruction. At the lowest temperature, the homogeneous rf spectrum shows an asymmetric excitation line shape with a peak at 0.48(4)$\epsilon_F$ with respect to the free atomic line, where $\epsilon_F$ is the local Fermi energy

First Measurement of Bose-Einstein Correlations in Proton-Proton Collisions at √s=0.9 and 2.36 TeV at the LHC

Bose-Einstein correlations have been measured using samples of proton-proton collisions at 0.9 and 2.36 TeV center-of-mass energies, recorded by the CMS experiment at the CERN Large Hadron Collider. The signal is observed in the form of an enhancement of pairs of same-sign charged particles with small relative four-momentum. The size of the correlated particle emission region is seen to increase significantly with the particle multiplicity of the event

Transverse-Momentum and Pseudorapidity Distributions of Charged Hadrons in pp Collisions at √s=7 TeV

Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at √s=7  TeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity dN_(ch)/dη||η|<0.5=5.78±0.01(stat)±0.23(syst) for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from √s=0.9 to 7 TeV is [66.1±1.0(stat)±4.2(syst)]%. The mean transverse momentum is measured to be 0.545±0.005(stat)±0.015(syst)  GeV/c. The results are compared with similar measurements at lower energies

Search for resonances in the dilepton mass distribution in pp collisions at √s = 7 TeV

A search for narrow resonances at high mass in the dimuon and dielectron channels has been performed by the CMS experiment at the CERN LHC, using pp collision data recorded at √s=7 TeV. The event samples correspond to integrated luminosities of 40 pb^(−1) in the dimuon channel and 35 pb^(−1) in the dielectron channel. Heavy dilepton resonances are predicted in theoretical models with extra gauge bosons (Z′) or as Kaluza-Klein graviton excitations (G_(KK)) in the Randall-Sundrum model. Upper limits on the inclusive cross section of Z′(G_(KK)) → ℓ^+ ℓ^− relative to Z → ℓ^+ ℓ^− are presented. These limits exclude at 95% confidence level a Z′ with standard-model-like couplings below 1140GeV, the superstring-inspired Z'_ψ below 887 GeV, and, for values of the coupling parameter kM_(Pl) of 0.05 (0.1), Kaluza-Klein gravitons below 855 (1079) GeV

Measurement of W^+W^− production and search for the Higgs boson in pp collisions at √s = 7 TeV

A measurement of W^+W^− production in pp collisions at √s = 7 TeV and a search for the Higgs boson are reported. The W^+W^− candidates are selected in events with two leptons, either electrons or muons. The measurement is performed using LHC data recorded with the CMS detector, corresponding to an integrated luminosity of 36 pb^(−1). The pp → W^+W^− cross section is measured to be 41.1±15.3 (stat)±5.8(syst)±4.5(lumi)pb consistent with the standard model prediction. Limits on WWγ and WWZ anomalous triple gauge couplings are set. The search for the standard model Higgs boson in the W^+W^− decay mode does not reveal any evidence of excess above backgrounds. Limits are set on the production of the Higgs boson in the context of the standard model and in the presence of a sequential fourth family of fermions with high masses. In the latter context, a Higgs boson with mass between 144 and 207 GeV/c^2 is ruled out at 95% confidence level