The predicting effects of depression and self-esteem on suicidal ideation among adolescents in Kuala Lumpur, Malaysia

Background: In Malaysia, the prevalence of adolescents’ suicidal ideation has increased over the years. Therefore, it is crucial to investigate the predictors of suicidal ideation among adolescents. Hence, the aim of this study was to examine the predicting effects of depression and self-esteem on suicidal ideation among Malaysian adolescents. In addition, the relationships between depression, self-esteem, and adolescents’ suicidal ideation were explored as well. Methods: By using a multistage cluster sampling method, a cross-sectional study was conducted in secondary schools in Kuala Lumpur, Malaysia. The participants were comprised of 852 adolescents (51% males and 49% females) aged 13-17 years old who completed self-administered questionnaires. Pearson’s Correlation analysis was used to analyse the relationships among depression, self-esteem, and adolescents’ suicidal ideation, while Standard Multiple Regression analysis was used to examine the predicting effects of depression and self-esteem on adolescents’ suicidal ideation. Results: Depression had a positive correlation with adolescents’ suicidal ideation (r = .290, p < .001), while self-esteem had a negative correlation with adolescents’ suicidal ideation (r = -.283, p < .001). Results also showed that both depression (β = .200, p < .001) and self-esteem (β = -.186, p < .001) significantly predicted adolescents’ suicidal ideation. Conclusion: The study found that depression is a risk factor, while self-esteem is a protective factor of adolescents’ suicidal ideation

Self-efficacy as a mediator of the relationship between parental closeness and suicidal ideation among Malaysian adolescents

Suicide has become a serious worldwide mental health problem, including Asian countries. Suicidal ideation happens prior to the actual suicidal behaviour; thus, identifying the roots of suicidal ideation is vital. This study investigated the relationships between parental closeness, self-efficacy and suicidal ideation among adolescents in Malaysia. The mediation effect of self-efficacy on the relationship between parental closeness and suicidal ideation was also examined. A total of 684 school-going adolescents aged 14–17 years old were recruited via multistage cluster sampling. Bivariate analysis was conducted using Pearson's correlation analysis. The mediation model was tested using SPSS macro developed by Preacher and Hayes. The results showed that mother closeness, father closeness and self-efficacy had significant negative correlation with suicidal ideation. Specifically, self-efficacy emerged as a partial mediator in the relation between mother closeness and suicidal ideation. Self-efficacy also fully mediated the relationship between father closeness and suicidal ideation. The findings implied that mother closeness had stronger correlation with adolescents' suicidal ideation compared to father closeness, while self-efficacy plays an important role in the relationship between parental closeness and suicidal ideation. Prevention and intervention efforts by practitioners dealing with adolescents' mental health issues, specifically on suicidal ideation, should seriously consider providing them with skills to enhance mother–adolescent relationship and their self-efficacy

Curbing Bribe-Giving in Malaysia: The Role of Attitudes and Parents

© The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/).One of the main challenges developing nations face is curbing bribery. While there are many efforts to curb bribery, most focused at macro level, such as law, while little has been examined at the micro level, e.g., individual behavior and intention. Those who did investigate at the micro level tend to focus on the recipients rather than the ones giving the bribe. We explored eight factors that influence Malaysian young adults’ bribe giving intention based on the Reasoned Action Approach (RAA). A total of 345 respondents (M age = 20.68, SD = 2.01, 189 are females) completed questionnaires about all RAA variables. Partial Least Squares Structural Equation Modelling (PLS-SEM) was carried out using smartPLS3.0 to analyze the result. The result revealed that out of the eight variables, four variables—Instrumental attitudes, Experiential Attitudes, Parents’ descriptive norms and Capacity—explain 74% of the variance in bribe giving intention. An important take-away is that young adult’s perception of whether their parents gave or did not give bribes in a given situation is important in influencing their bribe giving intention. Bribe giving prevention messages must be targeted explicitly toward parents, where they play a crucial role in curbing this dishonesty.Peer reviewe

Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity

<p>Abstract</p> <p>Background</p> <p>Influenza viruses are a major cause of morbidity and mortality around the world. More recently, a swine-origin influenza A (H1N1) virus that is spreading via human-to-human transmission has become a serious public concern. Although vaccination is the primary strategy for preventing infections, influenza antiviral drugs play an important role in a comprehensive approach to controlling illness and transmission. In addition, a search for influenza-inhibiting drugs is particularly important in the face of high rate of emergence of influenza strains resistant to several existing influenza antivirals.</p> <p>Methods</p> <p>We searched for novel anti-influenza inhibitors using a cell-based neutralization (inhibition of virus-induced cytopathic effect) assay. After screening 20,800 randomly selected compounds from a library from ChemDiv, Inc., we found that BPR1P0034 has sub-micromolar antiviral activity. The compound was resynthesized in five steps by conventional chemical techniques. Lead optimization and a structure-activity analysis were used to improve potency. Time-of-addition assay was performed to target an event in the virus life cycle.</p> <p>Results</p> <p>The 50% effective inhibitory concentration (IC₅₀) of BPR1P0034 was 0.42 ± 0.11 μM, when measured with a plaque reduction assay. Viral protein and RNA synthesis of A/WSN/33 (H1N1) was inhibited by BPR1P0034 and the virus-induced cytopathic effects were thus significantly reduced. BPR1P0034 exhibited broad inhibition spectrum for influenza viruses but showed no antiviral effect for enteroviruses and echovirus 9. In a time-of-addition assay, in which the compound was added at different stages along the viral replication cycle (such as at adsorption or after adsorption), its antiviral activity was more efficient in cells treated with the test compound between 0 and 2 h, right after viral infection, implying that an early step of viral replication might be the target of the compound. These results suggest that BPR1P0034 targets the virus during viral uncoating or viral RNA importation into the nucleus.</p> <p>Conclusions</p> <p>To the best of our knowledge, BPR1P0034 is the first pyrazole-based anti-influenza compound ever identified and characterized from high throughput screening to show potent (sub-μM) antiviral activity. We conclude that BPR1P0034 has potential antiviral activity, which offers an opportunity for the development of a new anti-influenza virus agent.</p

Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane

Vesicle fusion is executed via formation of an Ω-shaped structure (Ω-profile), followed by closure (kiss-and-run) or merging of the Ω-profile into the plasma membrane (full fusion). Although Ω-profile closure limits release but recycles vesicles economically, Ω-profile merging facilitates release but couples to classical endocytosis for recycling. Despite its crucial role in determining exocytosis/endocytosis modes, how Ω-profile merging is mediated is poorly understood in endocrine cells and neurons containing small ∼30–300 nm vesicles. Here, using confocal and super-resolution STED imaging, force measurements, pharmacology and gene knockout, we show that dynamic assembly of filamentous actin, involving ATP hydrolysis, N-WASP and formin, mediates Ω-profile merging by providing sufficient plasma membrane tension to shrink the Ω-profile in neuroendocrine chromaffin cells containing ∼300 nm vesicles. Actin-directed compounds also induce Ω-profile accumulation at lamprey synaptic active zones, suggesting that actin may mediate Ω-profile merging at synapses. These results uncover molecular and biophysical mechanisms underlying Ω-profile merging

Ecosystem-Driven Design of In-Home Terminals Based on Open Platform for the

Abstract—In-home healthcare services based on the Internet-of-Things (IoT) have great business potentials. To turn it into reality, a business ecosystem should be established first. Technical solutions should therefore aim for a cooperative ecosystem by meeting the interoperability, security, and system integration requirements. In this paper, we propose an ecosystem-driven design strategy and apply it in the design of an open-platform-based in-home healthcare terminal. A cooperative business ecosystem is formulated by merging the traditiona