Spatial-photonic Ising machine by space-division multiplexing with physically tunable coefficients of a multi-component model

This paper proposes a space-division multiplexed spatial-photonic Ising machine (SDM-SPIM) that physically calculates the weighted sum of the Ising Hamiltonians for individual components in a multi-component model. Space-division multiplexing enables tuning a set of weight coefficients as an optical parameter and obtaining the desired Ising Hamiltonian at a time. We solved knapsack problems to verify the system's validity, demonstrating that optical parameters impact the search property. We also investigated a new dynamic coefficient search algorithm to enhance search performance. The SDM-SPIM would physically calculate the Hamiltonian and a part of the optimization with an electronics process.Comment: 12 pages, 5 figure

LoCO: Local Cooperative Data Offloading System Based on Location Information, Journal of Telecommunications and Information Technology, 2019, nr 1

The development of high speed mobile networks and the widespread use of smartphones have enabled users to easily obtain large data volumes via the Internet. This causes a heavy consumption of network resources, a burden on the available bandwidth. To solve such problems, a data offloading method with a wireless LAN access point has been used to distribute traffic from mobile to fixed networks. However, the method using wireless LAN access points can only change the communication paths but cannot reduce the overall traffic. This paper proposes a local cooperative data offloading system (LoCO) that reduces the overall traffic by sharing data, with direct communication between neighbors based on their location-related information. Moreover, the authors implemented the LoCO system on Android smartphones and clarified its performance in comparison with a traditional client/server system through experiments to download data in a real-world environment

Establishment of a New Cell-Based Assay To Measure the Activity of Sweeteners in Fluorescent Food Extracts

Taste receptors have been defined at the molecular level in the past decade, and cell-based assays have been developed using cultured cells heterologously expressing these receptors. The most popular approach to detecting the cellular response to a tastant is to measure changes in intracellular Ca2+ concentration using Ca2+-sensitive fluorescent dyes. However, this method cannot be applied to food-derived samples that contain fluorescent substances. To establish an assay system that would be applicable to fluorescent samples, we tested the use of Ca2+-sensitive photoproteins, such as aequorin and mitochondrial clytin-II, as Ca2+ indicators in a human sweet taste receptor assay. Using these systems, we successfully detected receptor activation in response to sweetener, even when fluorescent compounds coexisted. This luminescence-based assay will be a powerful tool to objectively evaluate the sweetness of food-derived samples even at an industry level

Distinct Functions of Period2 and Period3 in the Mouse Circadian System Revealed by In Vitro Analysis

The mammalian circadian system, which is composed of a master pacemaker in the suprachiasmatic nuclei (SCN) as well as other oscillators in the brain and peripheral tissues, controls daily rhythms of behavior and physiology. Lesions of the SCN abolish circadian rhythms of locomotor activity and transplants of fetal SCN tissue restore rhythmic behavior with the periodicity of the donor's genotype, suggesting that the SCN determines the period of the circadian behavioral rhythm. According to the model of timekeeping in the SCN, the Period (Per) genes are important elements of the transcriptional/translational feedback loops that generate the endogenous circadian rhythm. Previous studies have investigated the functions of the Per genes by examining locomotor activity in mice lacking functional PERIOD proteins. Variable behavioral phenotypes were observed depending on the line and genetic background of the mice. In the current study we assessed both wheel-running activity and Per1-promoter-driven luciferase expression (Per1-luc) in cultured SCN, pituitary, and lung explants from Per2−/− and Per3−/− mice congenic with the C57BL/6J strain. We found that the Per2−/− phenotype is enhanced in vitro compared to in vivo, such that the period of Per1-luc expression in Per2−/− SCN explants is 1.5 hours shorter than in Per2+/+ SCN, while the free-running period of wheel-running activity is only 11 minutes shorter in Per2−/− compared to Per2+/+ mice. In contrast, circadian rhythms in SCN explants from Per3−/− mice do not differ from Per3+/+ mice. Instead, the period and phase of Per1-luc expression are significantly altered in Per3−/− pituitary and lung explants compared to Per3+/+ mice. Taken together these data suggest that the function of each Per gene may differ between tissues. Per2 appears to be important for period determination in the SCN, while Per3 participates in timekeeping in the pituitary and lung

Genetic and Molecular Analysis of Wild-Derived Arrhythmic Mice

A new circadian variant was isolated by screening the intercross offspring of wild-caught mice (Mus musculus castaneus). This variant was characterized by an initial maintenance of damped oscillations and subsequent loss of rhythmicity after being transferred from light-dark (LD) cycles to constant darkness (DD). To map the genes responsible for the persistence of rhythmicity (circadian ratio) and the length of free-running period (τ), quantitative trait locus (QTL) analysis was performed using F2 mice obtained from an F1 cross between the circadian variant and C57BL/6J mice. As a result, a significant QTL with a main effect for circadian ratio (Arrhythmicity; Arrh-1) was mapped on Chromosome (Chr) 8. For τ, four significant QTLs, Short free-running period (Sfp-1) (Chr 1), Sfp-2 (Chr 6), Sfp-3 (Chr 8), Sfp-4 (Chr 11) were determined. An epistatic interaction was detected between Chr 3 (Arrh-2) and Chr 5 (Arrh-3). An in situ hybridization study of clock genes and mouse Period1::luciferase (mPer1::luc) real-time monitoring analysis in the suprachiasmatic nucleus (SCN) suggested that arrhythmicity in this variant might not be attributed to core circadian mechanisms in the SCN neurons. Our strategy using wild-derived variant mice may provide a novel opportunity to evaluate circadian and its related disorders in human that arise from the interaction between multiple variant genes

Diffusion Tests for Chloride in Concrete Using Wind Tunnel Test

Diffusion coefficient of chloride in concrete is a predominant factor in chloride penetration into concrete. Two types of diffusion coefficient models are examined here: mean diffusion coefficient D, time-dependent diffusion coefficient D(t). These diffusion coefficients are experimentally derived from the chloride profiles in concrete obtained by the wind tunnel test. It is clearly shown that diffusion coefficients are dependent of water cement ratio but independent of intensity of airborne salt. Time-dependent diffusion coefficients derived based on constant and time-dependent surface chloride are not different. Diffusion coefficient also decreases with increasing of time as explained by other researcher

EFFECT OF PRESTRESSED FORCE AND SIZE OF REINFORCEMENT ON CORROSION CRACK WIDTH IN CONCRETE MEMBER

One of the main factors which terminate service life of concrete structure in corrosive environment is corrosion attack. Rust expansion of corroded reinforcement in concrete causes corrosion crack. Crack width due to corrosion on the surface of concrete is influenced by some factors, i.e., prestressed force, size of reinforcement and thickness of concrete cover. Effect of prestressed force and size of reinforcement in corrosion crack width is investigated using numerical simulation based on elastic expansion model which is adopted to discover those influences. Three specimens of prestressed concrete beam and three specimens of reinforced concrete beam are utilized in the investigation. Experimental work is carried out to validate the numerical simulation results. It is found that prestressed force has insignificant influence on corrosion crack width. Meanwhile, size of reinforcement contributes greatly on crack width due to corrosion on the surface of concrete