CT manifestations of the retrocrural space involvement in a 48-year-old man with AP.

<p>(<b>A</b>, <b>B</b>) CT scans obtained 3 days after admission showed acute fluid collections at the left subphrenic spaces. They resulted in the hydropsia of the left diaphragm (<i>long white arrow</i>), and the thickening of the left mediastinal pleura (<i>short white arrow</i>). In addition, a streaky density occurred at the left retrocrural space (<i>arrowhead</i>). On the opposite side, the right crus has a rough edge (<i>black arrow</i>). (<b>C</b>) CT scans displayed the peripancreatic fluid collections had extended into the left retroperitoneal space.</p

CT scans showing peripancreatic fluid draining into retrocrural space in a 46-year-old woman with AP.

<p>(<b>A</b>) On the upper section, CT scans obtained 4 days after admission showed the peripancreatic fluid had drained into the retrocrural space across the esophageal hiatus (<i>short white arrow</i>); then formed a fistulous tract into pleural cavity and developed into the pleural effusion (<i>long black arrow</i>). (<b>B</b>) On the middle section, pancreatic head necrosis is shown as a non-enhanced area that was less than 30% of total pancreatic area (<i>black arrowhead</i>). The bilateral diaphragmatic crus were shown hydropsia (<i>long white arrow</i>). (<b>C</b>) On the lower section, CT scans show the fluid had extended into the right retroperitoneal space (<i>short black arrow</i>) and further drained into the retrocrural space across the aortic hiatus (<i>white arrowhead</i>).</p

CTSI scoring system on CT scans in AP.

<p>CTSI scoring system on CT scans in AP.</p

Value of RCSI and CTSI scoring systems for predicting the mortality and severity of AP.

<p>MOR: mortality, SAP: severe acute pancreatitis, PPV: positive predictive value, NPV: negative predictive value.</p><p>Value of RCSI and CTSI scoring systems for predicting the mortality and severity of AP.</p

Visualization of the anatomic location of retrocrural space across diaphragmatic hiatuses section on CVH2.

<p>(<b>A</b>) On the upper section, the anterior margin of the retrocrural space (C) consists of the distal esophagus (D), the posterior border is thoracolumbar vertebra, both anterolateral borders are composed of the diaphragmatic crus (A), both posterolateral borders are made up of the mediastinal pleura (B). The aorta (E) is situated in the retrocrural space. The potential recess located between the diaphragmatic crura and the mediastinal pleura is the interior costophrenic sulcus (G). The peripancreatic fluid may drain into the retrocrural space via the esophageal hiatus (F). (<b>B</b>) On the lower section, the anterior border of the retrocrural space is open to the retroperotoneum, the posterior border is the lumbar vertebra, both lateral borders are made up of the diaphragmatic crus (A), the mediastinal pleura (B) constitutes the right posterolateral border. The inferior vena cava (K) and the both sides of adrenal glands (I) are distributed at the anterolateral direction of the retrocrural space. Furthermore, the peripancreatic fluid that originates from the pancreas (J) may drain into the retrocrural space across the aortic hiatus (H).</p

ROC curves of the RCSI and CTSI score in distinguishing between mild and severe AP.

<p>(a: cutoff value = 3.0, sensitivity = 79.38%, specificity = 87.50%; b: cutoff value = 4.0, sensitivity = 81.91%, specificity = 91.41%).</p

ROC curves of the RCSI score and CTSI score in predicting the mortality.

<p>(a: cutoff value = 4.0, sensitivity = 82.11%, specificity = 96.91%; b: cutoff value = 2.0, sensitivity = 77.27%, specificity = 91.12%).</p

MOESM1 of Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

Additional file 1. Six supplementary figures and three supplementary tables