A potential glucuronate glycosyl donor with 2-O-acyl-6,3-lactone structure: efficient synthesis of glycosaminoglycan disaccharides

Development of β-selective glucuronylation reaction using phenyl 2,4-di-O-acetyl-1-thio-β-D-glucopyranosidurono-6,3-lactone was described. Glycosylations of this glycosyl donor with hexosamine derivatives proceeded with excellent yield and β-stereoselectivity to afford glycosaminoglycan-type disaccharides