The study of relationship between quality of occupational life and progress motivation in health team of Ashayer hospital in Khorramabad

زمینه و هدف: اهمیت بهره‌وری نیروی انسانی با انگیزه پیشرفت بالا در حیات و تداوم زندگی سازمان‌ها نقش به‌سزایی دارد. امروزه بهبود کیفیت زندگی کاری کارکنان به یکی از مهم‌ترین اهداف سازمان تبدیل شده است. هدف از این تحقیق تعیین رابطه بین کیفیت زندگی کاری و انگیزش پیشرفت کادر‌درمانی بیمارستان شهدای عشایر شهر خرم‌آباد بود. روش ‌بررسی: تحقیق حاضر از نوع توصیفی تحلیلی از نوع مقطعی است. جامعه آماری در این تحقیق شامل تمامی کادر‌درمانی بیمارستان عشایر شهر خرم‌آباد در سال 1394 می‌باشد، به این ترتیب تعداد 205 نفر از میان آن‌ها به‌عنوان نمونه آماری با روش نمونه‌گیری تصادفی ساده انتخاب شدند. برای گردآوری اطلاعات از پرسشنامه‌های استاندارد سنجش کیفیت زندگی کاری(QWL) و پرسشنامه هرمانز (AMQ) برای سنجش انگیزش پیشرفت، استفاده شد. روایی پرسشنامه‌ها توسط ده نفر از اساتید مورد تأیید قرار گرفت. پایایی ابزار‌های فوق به‌ترتیب با ضریب آلفای کرونباخ 87/0 برای پرسشنامه کیفیت زندگی کاری و 79/0 برای پرسشنامه هرمانز به‌دست آمد. تجزیه و تحلیل داده‌ها با استفاده از آزمون‌های همبستگی پیرسون برای سنجش ارتباط بین ابعاد کیفیت زندگی کاری و انگیزش پیشرفت و تحلیل رگرسیون چند‌گانه برای سنجش ضریب تعیین هر‌یک از مولفه‌های کیفیت زندگی کاری روی انگیزش پیشرفت انجام شد. یافته‌ها: نتایج نشان می‌دهند که بین کیفیت زندگی کاری و انگیزش پیشرفت کادر‌ درمان رابطه مستقیم و معنی‌داری وجود دارد (001/0>P، 370/0=r). بین پرداخت منصفانه و کافی و انگیزش پیشرفت (001/0>P، 754/0=r)، محیط کاری ایمن و بهداشتی و انگیزش پیشرفت (001/0>P، 806/0=r)، فرصت رشد و امنیت مداوم و فرسودگی شغلی (001/0>P، 692/0=r)، وابستگی اجتماعی زندگی کاری و فرسودگی شغلی (001/0>P، 760/0=r) رابطه مثبت معنی داری وجود داشت. بین فضای کلی زندگی و انگیزش پیشرفت (001/0>P، 650/0=r) و توسعه قابلیت‌های انسانی و انگیزش پیشرفت (001/0>P، 677/0=r) رابطه مثبت و معنی‌داری وجود داشت. نتیجه‌‌گیری: در‌صورتی‌که کیفیت زندگی کاری کادر‌درمان بیمارستان بهبود یابد، انگیزش پیشرفت آنان نیز افزایش خواهد یافت

Jursprudentical and Legal Critique of “Tatarros” and “Avoidance of Taghut” in the Foundations of Takfiri Terrorism

Takfiri terrorism, as a political phenomenon for those claiming power in form of religious groups is expanding in Islamic countries and has become the greatest challenge for the Islamic world. Misuse of jurisprudential rules named "Tatarros" and "Avoidance of Taghut" is the most abject mental and practical approach that is being practised by this group. The present article adopts library and descriptive-analytical methods to examine major principles of Takfiri terrorism from the perspective of jurisprudence and law. The purpose of this study is to prove that the main principles of Takfiri terrorism, namely the jurisprudential rule of "Tatarros" and "Avoidance of Taghut", seek aggression and other forms of terror in Islamic countries and that the killing of Muslims by Takfiris is unrelated to the rule of Tatarros. The question is what conditions govern these rules according to Islamic jurists and whether these rules entail suicide attacks and the killing of civilians

Removal of Ortho- chlorophenol from Aqueous Solutions Using Zero-Valent Iron Nanoparticles Modified Clay (Case Clay Soils of ShahMorad Mountains in Rafsanjan)

Chlorophenols as priority pollutants are toxic. These acidic organic compounds cause digestive disorders, liver damage, and cancers. The aim of this study is Ortho- chlorophenol removal using zero-valent iron nanoparticles modified clay. In this experimental study, the clay soil was sampled from the mountains of Shah Murad, Rafsanjan, Iran. Then it was treated with hydrochloric acid. In the next step, the clay was modified with ferrous sulfate in the presence of the N2 gas to prepare magnetic clay. Then, the prepared adsorbent was used to remove o-chlorophenol as a function of pH, adsorbent dose and contact time. In addition, adsorption isotherms and kinetics were determined. The findings of the present study showed that the removal efficiency obtained by the iron nanoparticles carrying clay was higher than that of the raw clay. The highest removal efficiency (91.3 %.) was obtained for pH 4. The o-CP removal efficiency by the modified clay increased from 35.9 to 82.7 as the adsorbent dosage is increased from 0.05 to 1 g after 120min contact time. The Langmuir isotherm model and the second-order kinetic model provided the best fit to the experimental data compared to other studied models. The results showed that the modified adsorbent could be used an effective and readily available low-cost adsorbent for the removal of chlorophenols in industrial applications

Removal of Ortho- chlorophenol from Aqueous Solutions Using Zero-Valent Iron Nanoparticles Modified Clay (Case Clay Soils of ShahMorad Mountains in Rafsanjan)

Chlorophenols as priority pollutants are toxic. These acidic organic compounds cause digestive disorders, liver damage, and cancers. The aim of this study is Ortho- chlorophenol removal using zero-valent iron nanoparticles modified clay. In this experimental study, the clay soil was sampled from the mountains of Shah Murad, Rafsanjan, Iran. Then it was treated with hydrochloric acid. In the next step, the clay was modified with ferrous sulfate in the presence of the N2 gas to prepare magnetic clay. Then, the prepared adsorbent was used to remove o-chlorophenol as a function of pH, adsorbent dose and contact time. In addition, adsorption isotherms and kinetics were determined. The findings of the present study showed that the removal efficiency obtained by the iron nanoparticles carrying clay was higher than that of the raw clay. The highest removal efficiency (91.3 %.) was obtained for pH 4. The o-CP removal efficiency by the modified clay increased from 35.9 to 82.7 as the adsorbent dosage is increased from 0.05 to 1 g after 120min contact time. The Langmuir isotherm model and the second-order kinetic model provided the best fit to the experimental data compared to other studied models. The results showed that the modified adsorbent could be used an effective and readily available low-cost adsorbent for the removal of chlorophenols in industrial applications

The effect of corrective exercises on musculoskeletal disorders of Khoramabad workers

زمینه و هدف: با توجه به لزوم شناخت اختلالات اسکلتی- عضلانی در کارگران به منظور ارتقاء سلامت آنان به عنوان بخش عظیمی از سرمایه کاری کشور و کمبود مطالعه در زمینه ارائه راهکار برای بهبود این اختلالات، مطالعه حاضر با هدف ارزیابی تأثیر تمرینات ورزشی اصلاحی بر اختلالات اسکلتی عضلانی کارگران در شهر خرم‌آباد در سال 1391، انجام شد. روش بررسی: مطالعه حاضر پژوهشی نیمه تجربی است، جامعه آماری مورد مطالعه کارگران مرد مرکز صنعتی شماره 1 و 2 شهر خرم‌ آباد بود. 320 نفر در ارزیابی اولیه مورد بررسی قرار گرفتند که 196 نفر با توجه به معیارهای ورود به مطالعه، شرایط مطالعه را داشته و به پرسشنامه پاسخ دادند. ابزار پژوهش پرسشنامه استاندارد بررسی اختلالات اسکلتی- عضلانی نوردیک بود. برنامه اصلاح اختلالات با توجه به موارد شناسایی شده (113 مورد) توسط کارشناس تربیت بدنی اجرا شد. تمرینات اصلاحی به صورت کششی و تقویتی در 24 جلسه به مدت 8 هفته انجام شد. یافته‌ها: 113 نفر سابقه درد و ناراحتی در اندام و اعضاء اسکلتی عضلانی خود داشتند و هیچ‌گونه سابقه قبلی بیماری نداشتند. 58 کارگران حداقل در یکی از نواحی نه‌ گانه مورد بررسی بدن دچار اختلالات اسکلتی- عضلانی بودند که بیشترین شیوع در ناحیه کمر (6/31)، گردن (8/19) شانه (5/29) و زانو (8/17) بود. پس از مداخله کاهش معنی ‌داری (05/0˂P) در مشکلات تمامی نواحی نه ‌گانه دیده شد. نتیجه‌گیری: تمرینات اصلاحی باعث کاهش درد و مشکلات اسکلتی- عضلانی کارگران می‌شود

Psychometric Properties of the Persian Internet Addiction Test-Social Networking Sites Version: Dimensionality Assessment of Social Networking Site Addiction

Background: By evaluating the psychometric properties of the Persian version of the Internet Addiction Test-Social Networking Sites version (IAT-SNS) in a sample of Iranian university students, this study investigated the dimensionality of SNS addiction for the first time. Methods: A total of 620 SNS users (414 women) participated in the study. The study questionnaire comprised demographic information, SNS usage patterns, the IAT-SNS, and the Bergen Social Media Addiction Scale (BSMAS). Findings: Exploratory factor analysis (EFA) identified the 3-factor structure of the IAT-SNS, namely ‘Lack of Control’, ‘Emotional and Relational Conflict’, and ‘Preference for online relationships’ that explained 54% of the total variance. Confirmatory factor analysis (CFA) verified the current model. Problematic users on average exhibited higher scores on the whole IAT-SNS and each of the 3 factors as compared to non-problematic users. The IAT-SNS and its factors showed good internal consistency, and strong convergent and concurrent validity. Conclusion: The Persian version of the IAT–SNS is valid and reliable, and is applicable for measuring the 3 dimensions of SNS addiction among students

Salvurmin A and Salvurmin B, Two Ursane Triterpenoids of Salvia urmiensis Induce Apoptosis and Cell Cycle Arrest in Human Lung Carcinoma Cells

Background: Ursane triterpenoids could be considered as novel multi-target therapeutic anti-cancer agents. Salvurmin A and Salvurmin B are novel cytotoxic ursane triterpenoids isolated from the aerial parts of Salvia urmiensis, an endemic plant species of Iran. Methods: In this study, we assessed cytotoxicity of these compounds against two human cancer cell lines and one human normal cell line and investigated its mechanism via apoptosis and cell cycle arrest. Results: Salvurmin A and B showed the most cytotoxic effect on A549 cells compared to other studied cancer cells. IC50 values for Salvurmin A and B against A549 cells were 35.6 ± 1.5 and 19.2 ± 0.8 µM, respectively. Based on annexin V staining, both of these compounds significantly induced apoptosis in A549 cells. Moreover, these two compounds significantly increased cell accumulation in G2/M and decreased the number of cells in G0/G1 phases in A549 cells in a dose-dependent manner. Conclusion: Based on the results Salvurmin B can be considered as potential candidate for further studies against human lung carcinoma

Invasive Fusarium rhinosinusitis in COVID-19 patients: report of three cases with successful management

Invasive fungal rhinosinusitis (IFRS) is a life-threatening infection that can occur in immunocompromised patients, including those with COVID-19. Although Mucorales and Aspergillus species are the most common causes of IFRS, infections caused by other fungi such as Fusarium are rare. In this report, we present three cases of proven rhinosinusitis fusariosis that occurred during or after COVID-19 infection. The diagnosis was confirmed through microscopy, pathology, and culture, and species identification of the isolates was performed by DNA sequencing the entire ITS1-5.8 rRNA-ITS2 region and translation elongation factor 1-alpha (TEF-1α). Antifungal susceptibility testing was conducted according to CLSI guidelines. The causative agents were identified as Fusarium proliferatum, F. oxysporum + Aspergillus flavus, and F. solani/falciforme. Treatment involved the administration of antifungal medication and endoscopic sinus surgery to remove the affected mucosa, leading to the successful resolution of the infections. However, one patient experienced a recurrence of IFRS caused by A. flavus 15 months later. Early diagnosis and timely medical and surgical treatment are crucial in reducing mortality rates associated with invasive fusariosis. Additionally, the cautious use of corticosteroids in COVID-19 patients is highly recommended

The clinical and genetic spectrum of autosomal-recessive TOR1A-related disorders.

In the field of rare diseases, progress in molecular diagnostics led to the recognition that variants linked to autosomal-dominant neurodegenerative diseases of later onset can, in the context of biallelic inheritance, cause devastating neurodevelopmental disorders and infantile or childhood-onset neurodegeneration. TOR1A-associated arthrogryposis multiplex congenita 5 (AMC5) is a rare neurodevelopmental disorder arising from biallelic variants in TOR1A, a gene that in the heterozygous state is associated to torsion dystonia-1 (DYT1 or DYT-TOR1A), an early-onset dystonia with reduced penetrance. While 15 individuals with TOR1A-AMC5 have been reported (less than 10 in detail), a systematic investigation of the full disease-associated spectrum has not been conducted. Here, we assess the clinical, radiological and molecular characteristics of 57 individuals from 40 families with biallelic variants in TOR1A. Median age at last follow-up was 3 years (0-24 years). Most individuals presented with severe congenital flexion contractures (95%) and variable developmental delay (79%). Motor symptoms were reported in 79% and included lower limb spasticity and pyramidal signs, as well as gait disturbances. Facial dysmorphism was an integral part of the phenotype, with key features being a broad/full nasal tip, narrowing of the forehead and full cheeks. Analysis of disease-associated manifestations delineated a phenotypic spectrum ranging from normal cognition and mild gait disturbance to congenital arthrogryposis, global developmental delay, intellectual disability, absent speech and inability to walk. In a subset, the presentation was consistent with fetal akinesia deformation sequence with severe intrauterine abnormalities. Survival was 71% with higher mortality in males. Death occurred at a median age of 1.2 months (1 week - 9 years) due to respiratory failure, cardiac arrest, or sepsis. Analysis of brain MRI studies identified non-specific neuroimaging features, including a hypoplastic corpus callosum (72%), foci of signal abnormality in the subcortical and periventricular white matter (55%), diffuse white matter volume loss (45%), mega cisterna magna (36%) and arachnoid cysts (27%). The molecular spectrum included 22 distinct variants, defining a mutational hotspot in the C-terminal domain of the Torsin-1A protein. Genotype-phenotype analysis revealed an association of missense variants in the 3-helix bundle domain to an attenuated phenotype, while missense variants near the Walker A/B motif as well as biallelic truncating variants were linked to early death. In summary, this systematic cross-sectional analysis of a large cohort of individuals with biallelic TOR1A variants across a wide age-range delineates the clinical and genetic spectrum of TOR1A-related autosomal-recessive disease and highlights potential predictors for disease severity and survival

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation