Effect of Mn on <100> Texture Evolution in Fe-Si-Mn Alloys

The texture can be evolved through the gamma to a transformation by cooling in Fe-Si alloy systems. Oxygen in the annealing atmosphere hampers the evolution of the texture. The texture evolution is associated with the fact that the {100} faces are elastically compliant so that the texture can develop in a manner consistent with minimization of strain energy. By alloying Mn to Fe-Si alloys, the texture evolves in relatively high oxygen containing annealing atmosphere. The role of Mn in the texture evolution appears to be preventing formation of surface oxides, which modify the elastic modulus of metal surface, thereby suppress the development of the correct texture.1111sciescopu

BLZ8 activates a plastidial peroxiredoxin and a ferredoxin to protect Chlamydomonas reinhardtii against oxidative stress

Reactive oxygen species (ROS) cause damage to various cellular processes in almost all organisms, in particular photosynthetic organisms that depend on the electron transfer chain for CO2 fixation. However, the detoxifying process to mitigate ROS damage has not been studied intensively in microalgae. Here, we characterized the ROS detoxifying role of a bZIP transcription factor, BLZ8, in Chlamydomonas reinhardtii. To identify downstream targets of BLZ8, we carried out comparative genome-wide transcriptomic profiling of BLZ8 OX and its parental CC-4533 under oxidative stress conditions. Luciferase reporter activity assays and RT-qPCR were performed to test whether BLZ8 regulates downstream genes. We performed an in silico functional gene network analysis and an in vivo immunoprecipitation assay to identify the interaction between downstream targets of BLZ8. Comparative transcriptomic analysis and RT-qPCR revealed that overexpression of BLZ8 increased the expression levels of plastid peroxiredoxin1 (PRX1) and ferredoxin-5 (FDX5) under oxidative stress conditions. BLZ8 alone could activate the transcriptional activity of FDX5 and required bZIP2 to activate transcriptional activity of PRX1. Functional gene network analysis using FDX5 and PRX1 orthologs in A. thaliana suggested that these two genes were functionally associated. Indeed, our immunoprecipitation assay revealed the physical interaction between PRX1 and FDX5. Furthermore, the complemented strain, fdx5 (FDX5), recovered growth retardation of the fdx5 mutant under oxidative stress conditions, indicating that FDX5 contributes to oxidative stress tolerance. These results suggest that BLZ8 activates PRX1 and FDX5 expression, resulting in the detoxification of ROS to confer oxidative stress tolerance in microalgae. © 2023 John Wiley & Sons Ltd. Published by John Wiley & Sons Ltd.11Nsciescopu

Cerebrovascular disease influences functional and structural network connectivity in patients with amnestic mild cognitive impairment and Alzheimer's disease

10.1186/s13195-018-0413-8Alzheimer's Research and Therapy1018

Distinct BOLD variability changes in the default mode and salience networks in Alzheimer’s disease spectrum and associations with cognitive decline

10.1038/s41598-020-63540-4Scientific Reports101645

Longitudinal trajectory of Amyloid-related hippocampal subfield atrophy in nondemented elderly

10.1002/hbm.24928Human Brain Mapping4182037-204